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N,N-Dimethylacetamide suppliers in China
Cas No: 127-19-5
USD $ 1.0-1.0 / Kilogram 1 Kilogram 1-1000 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
N,N-Dimethylacetamide/ DMAC
Cas No: 127-19-5
No Data 1 Metric Ton 1000 Metric Ton/Year Hefei TNJ chemical industry co.,ltd Contact Supplier
Cas No: 127-19-5
No Data No Data Metric Ton/Day Hangzhou Yierdechem Co. Ltd Contact Supplier
Cas No: 127-19-5
No Data 1 Metric Ton Metric Ton/Day HANGZHOU CLAKE BIOTECH CO.,LTD Contact Supplier
Dimethylacetamide suppliers in China CAS NO.127-19-5 inventory
Cas No: 127-19-5
USD $ 1.0-1.1 / Liter 500 Liter 3778 Kilogram/Day Shanghai VastPro Technology Development Co., Ltd. Contact Supplier
Cas No: 127-19-5
USD $ 1.0-20.0 / Kiloliter 1 Kiloliter 1.5 Metric Ton/Day Hangzhou Keyingchem Co.,Ltd Contact Supplier
Cas No: 127-19-5
USD $ 1300.0-1300.0 / Gram 10000 Gram 10 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
N,N-Dimethylacetamide CAS:127-19-5 Safe delivery Free of customs clearance
Cas No: 127-19-5
USD $ 1.0-10.0 / Kilogram 1 Kilogram 5000 Kilogram/Month WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
DMAC --- N,N-Dimethylacetamide -- CHemwill
Cas No: 127-19-5
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 5 Metric Ton/Day Chemwill Asia Co., Ltd. Contact Supplier
Cas No: 127-19-5
USD $ 2.0-3.0 / Kilogram 1 Kilogram 50 Metric Ton/Day EAST CHEMSOURCES LIMITED Contact Supplier

127-19-5 Usage

Production method

1. Acetic anhydride method dimethylamine and acetic anhydride have acylation reaction at 0-20 ℃, and then neutralized with low temperature liquid removing acetic, isolated from sodium acetate and Neutralization Solution and alkali washing, distillation, boiling range 164-166.5 DEG C fraction for the finished product. Material consumption fixed: acetic anhydride (95%) 1150kg/t, dimethylamine (40%) 1898kg/t.
2. Acetyl chloride method, by the reaction of dimethylamine and chloride, can also be prepared in dimethylacetamide. Compared with the process of the current domestic acetic anhydride process, it can reduce production costs, and improve economic efficiency.
3. Acetic acid method Fushun Research Institute of Chemical equipment using acetic acid and dimethylamine synthesis, and achieved good results. The process is characterized by the use of advanced catalytic distillation technology, strengthen reaction, reduce energy consumption, separation and product yield greatly improved, simplified the process. Compared to the synthesis process of this technology and two methylacetamide acetic anhydride methods, it can reduce production costs, improve economic benefits. China is currently more of people use it.
4. Study abroad Oxo trimethylamine and carbon monoxide carbonylation synthesis to produce N,N-dimethylacetamide approach. The reaction with iron, cobalt, nickel iodide or bromide as a catalyst.

Air & Water Reactions

Water soluble.


N,N-dimethylacetamide dimethyl amine, also known as an acetyl group, an acetyl dimethylamine, referred to as the DMAC, which is a highly polar aprotic solvent, micro ammonia odor, very strong dissolving power, soluble wide, miscible with water, aromatics, esters, ketones, alcohols, ether, benzene and chloroform and other arbitrary and enable activation of molecular compounds. It is widely used as a solvent and a catalyst. The solvent, with high boiling point, flash point, thermal stability and chemical stability of the solvent, is used for polyacrylonitrile spinning solvent, synthetic resin and natural resins, formic acid vinyl ester resin, vinyl pyridine copolymer and aromatic carboxylic acid. The catalyst can be used in the process of urea heating to produce the reaction of cyanide, sodium halide and metal cyanide to produce the reaction of alkyl acetylene, organic halide and isocyanate. N,N-dimethylacetamide also can be used as electrolytic solvent and photography with coupler solvent, de paint agent, organic synthesis of raw materials, pesticide and pharmaceutical raw materials. Separation of styrene from C8 fraction, extraction, distillation, solvent, etc..
Invasive dangerous situation
Inhaled toxic (toxicity stronger than dimethylformamide), decomposition products may be absorbed through the skin, eye, skin and mucous membranes, which have a strong irritant. See "dimethylformamide." Combustible. Rat oral LD505.4ml/kg. The allowable concentration in air is US 10ppm (35mg/m3).

Flammability hazard characteristics

In case of fire, high temperature, strong oxidants combustible; combustion emissions of toxic nitrogen oxide fumes.

Acute toxicity

Oral-rat LD50: 4300 mg/kg; Oral-Mouse LD50: 4620 mg/kg


The N, N-Dimethylacetamide are incompatible wiyb carbon tetrachloride and other halogenated compounds. Unsaturated aliphatic compounds are soluble in this product, but saturated aliphatic solubility of the compound in this product is small. The solubility of hydrolysis product is small. But in the presence of acid, it can accelerate the hydrolysis. This product has good stability, and it does not decompose during distillation. With a strong base to form acetates and alkyl amines, in the presence of a proton, the alcohol can have solution when heated.


  • Used in organic synthesis, also used as solvents, catalysts, and paint removers.
  • DMAC is mainly used as synthetic fibers (acrylonitrile) and polyurethane spinning synthetic polyamide resin and a solvent, but also it is used for separating styrene from the C8 fraction extractive distillation solvent, and it is widely used in the aspects of polymer films, coatings and medicine. Currently it is used to synthesize a large number of antibiotics and pesticides in the pharmaceutical and pesticide. The catalyst can also be used for the reaction, electrolytic solvent, paint scavengers and various crystalline solvent adducts and complexes.
  • Used as the reaction solvent of pharmaceutical synthesis, synthetic fiber spinning solvents and synthetic resins, photographic chemicals chromogenic agent solvents, paints and other solvents, catalyst.

Stimulus data

Skin-Rabbit 10 mg/24 hr mild; Eye-rabbit mild 100 mg

Penetration pathways

Steam inhalation, skin absorption, ingestion, contact with the eyes and skin.
The workers, who are often exposed to dimethyl acetamide, observed jaundice, liver damage, but in general it can be quickly restored. When someone with FDA uses it as anticancer drugs and large doses of oral symptoms, it can cause depression, lethargy, visual hallucinations. It may also occur heart, kidney and brain degeneration. DMA mouse embryo has toxic effects on the rabbit have teratogenic effects.

Test methods

Measured in the air: adsorption with silica, methanol and analyzed by gas chromatography.


Flammable liquids


ChEBI: A member of the class of acetamides that is acetamide in which the hydrogens attached to the N atom have been replaced by two methyl groups respectively. Metabolite observed in cancer metabolism.

Chemical Properties

Transparent colorless liquid. The organic solvent can be mixed with any water, alcohol, ether, ester, benzene, chloroform, and aromatic compounds.

General Description

A clear colorless liquid with a faint odor similar to ammonia. About the same density as water. Flash point 145°F. Vapors heavier than air. May by toxic by skin absorption. May irritate eyes and skin.

Toxicity grading


Occupational standards

TLV-TWA 10 PPM (35 mg/cubic meter); STEL 15 PPM (50 mg/m3)


Solvent for many organic reactions and in industrial applications.


Storage with iron costumes to prevent the mechanical damage. Store in a cool, dry place, avoid light exposure, away from any possible source of ignition.

Chemical Properties

colourless liquid with a faint ammonia odour

Health Hazard

Liquid causes mild irritation of eyes and skin. Ingestion causes depression, lethargy, confusion and disorientation, visual and auditory hallucinations, perceptual distortions, delusions, emotional detachment, and affective blunting.

Purification Methods

Shake the amide with BaO for several days, reflux it with BaO for 1hour, then fractionally distil it under reduced pressure. Store it over molecular sieves. [Beilstein 4 IV 180.]

Reactivity Profile

N,N-Dimethylacetamide is an amide. Incompatible with oxidizing agents and halogenated compounds. Exothermic reactions occur with carbon tetrachloride and hexachlorocyclohexane. N,N-Dimethylacetamide can react violently in the presence of iron. Special Hazards of Combustion Products: Emits carbon oxides, nitrogen oxides, and dimethylamine when heated to decomposition.

Transport requirements

N,N-dimethylacetamide Department are toxic flammable liquids, adjustment shall be toxic substances provides storage and transportation. Transportation shall be marked "dangerous drugs" mark, and prevent the sun, impact, when handling, attention gently on the container.
Recommended methods of controlling waste incineration (incinerators shall have a scrubber or thermal means to reduce the discharge of NOx).

Fire Hazard

N,N-Dimethylacetamide is combustible.

Protective measures

Workshop should be ventilated, confined to production equipment. At high vapor concentrations work place, you should use an organic vapor respirator or air supplied respirator, gloves and protective clothing to prevent absorption through the skin. Wear goggles to prevent splashing into the eyes. In the workplace with splashing or spills of this substance, you should be taken off the wet clothes immediately and thoroughly wash the contaminated surface of the skin. Distribute to workers clean clothes before going to work every day, and take a shower after work.

Extinguishing agent

Foam, powder, carbon dioxide

Explosive hazardous characteristics

Mixed with air can be explosive

Medical Care

When the pre-employment and periodic medical examinations, we should pay special attention to the skin, the central nervous system, liver disease or liver function tests.

First aid

If such chemicals like splashed into the eyes, you should rinse with running water 15min immediately; if contact with skin, you should wash it immediately with plenty of water; if they are swallowed, you should be given medical attention, clothing with plenty of water, induce vomiting, gastric lavage. Do not induce vomiting with unconscious person. Instead, they should be sent to the hospital at once.

127-19-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
USP (1601485)  ResidualSolventClass2-N,N-Dimethylacetamide  United States Pharmacopeia (USP) Reference Standard 127-19-5 1601485-3X1.2ML 4,662.45CNY Detail
Aldrich (17308)  N,N-Dimethylacetamide  for peptide synthesis, ≥99.8% (GC) 127-19-5 17308-2.5L 2,676.96CNY Detail
Aldrich (17308)  N,N-Dimethylacetamide  for peptide synthesis, ≥99.8% (GC) 127-19-5 17308-1L 1,198.08CNY Detail
Sigma-Aldrich (38840)  N,N-Dimethylacetamide  puriss. p.a., ≥99.5% (GC) 127-19-5 38840-2.5L-F 2,393.82CNY Detail
Sigma-Aldrich (38840)  N,N-Dimethylacetamide  puriss. p.a., ≥99.5% (GC) 127-19-5 38840-1L-F 1,432.08CNY Detail
Aldrich (185884)  N,N-Dimethylacetamide  ReagentPlus®, ≥99% 127-19-5 185884-6X500ML 3,739.32CNY Detail
Aldrich (185884)  N,N-Dimethylacetamide  ReagentPlus®, ≥99% 127-19-5 185884-2.5L 1,283.49CNY Detail
Aldrich (185884)  N,N-Dimethylacetamide  ReagentPlus®, ≥99% 127-19-5 185884-500ML 747.63CNY Detail
Vetec (V900211)  N,N-Dimethylacetamide  Vetec reagent grade, 98% 127-19-5 V900211-6X500ML 625.95CNY Detail
Vetec (V900211)  N,N-Dimethylacetamide  Vetec reagent grade, 98% 127-19-5 V900211-500ML 125.19CNY Detail
Sigma-Aldrich (154806)  N,N-Dimethylacetamide  spectrophotometric grade, ≥99% 127-19-5 154806-2L 1,990.17CNY Detail
Sigma-Aldrich (154806)  N,N-Dimethylacetamide  spectrophotometric grade, ≥99% 127-19-5 154806-1L 1,407.51CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name N,N-dimethylacetamide

1.2 Other means of identification

Product number -
Other names N,N-Dimethylacetamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. CBI,Finishing agents,Intermediates,Processing aids, not otherwise listed,Solvents (which become part of product formulation or mixture)
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:127-19-5 SDS

127-19-5Related news

Full Length ArticleThermophysical study of the binary mixtures of N,N-Dimethylacetamide (cas 127-19-5) with 2-propanol and 2-butanol09/30/2019

This work reports thermophysical properties measurements of binary mixtures of N,N-dimethylacetamide with 2-propanol and 2-butanol. Density, ρ, speed of sound, u, refractive index, nD, and kinematic viscosity, ν, were measured over the whole composition range at the temperatures (283.15, 298.1...detailed

Solvation of alkaline earth metal ions in N,N-dimethylformamide and N,N-Dimethylacetamide (cas 127-19-5) – A volumetric and acoustic study09/29/2019

Densities and sound velocities at temperatures (298.15, 303.15, 308.15, 313.15 and 318.15) K of magnesium(II), calcium(II) and strontium(II) trifluoromethanesulfonates (triflates), as well as barium(II) perchlorate in N,N-dimethylformamide (dmf) and N,N-dimethylacetamide (dma) have been measured...detailed

Thermodynamics of amide + amine mixtures. 5. excess molar enthalpies of N,N-dimethylformamide or N,N-Dimethylacetamide (cas 127-19-5) + N-propylpropan-1-amine, + N-butylbutan-1-amine, + butan-1-amine, or + hexan-1-amine systems at 298.15 K. application of the ERAS model09/28/2019

Excess molar enthalpies, HmE, over the whole composition range have been determined for the liquid mixtures N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMA) + butan-1-amine (BA), or + hexan-1-amine (HxA), or + N-propylpropan-1-amine (DPA), or N-butylbutan-1-amine (DBA) at 298.15 K and ...detailed

Thermophysical study of the binary mixtures of N,N-Dimethylacetamide (cas 127-19-5) with 1-propanol and 1-butanol09/26/2019

Several thermophysical properties such as densities, ρ, speeds of sound, u, refractive indices, nD, and kinematic viscosities, ν, have been measured for the binary mixtures of N,N-Dimethylacetamide with 1-propanol and 1-butanol over the entire range of composition, at the temperatures (283.15,...detailed

Convenient N-acetylation of amines in N,N-Dimethylacetamide (cas 127-19-5) with N,N-carbonyldiimidazole09/24/2019

Dimethylacetamide (DMAc) acts as an efficient source of acetyl and dimethylamine gas in the presence of N,N-carbonyldiimidazole (CDI). Addition of amines to the reaction mixture delivers the corresponding amides in good to excellent yields. The acetylation of amines reported herein, which relies...detailed

Solvation of ionic liquids based on N-methyl-N-alkylmorpholinium cations in N,N-dimethylformamide and N,N-Dimethylacetamide (cas 127-19-5) – Volumetric and compressibility studies09/10/2019

Density and sound velocity of the solutions of ionic liquids based on N-alkyl-N-methyl- morpholinium cations: N-ethyl-N-methylmorpholinium bis(trifluoromethanesulfonyl)imide, N-butyl-N-methylmorpholinium bis(trifluoromethanesulfonyl)imide, N-octyl-N-methyl -morpholinium bis(trifluoromethanesulfo...detailed

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