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127-19-5

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127-19-5 Usage

General Description

N,N-Dimethylacetamide (DMAc) is a versatile polar solvent primarily used as a raw material in producing polyimides and polyacrylonitriles. It is a colorless, high boiling point organic liquid characterized by its low toxicity and a faint, specific amine-like odor. DMAc is miscible with water, and most organic solvents. Its chemical formula is C4H9NO. It's used in a wide range of applications, including in the pharmaceutical and textile industries, as well as for the production of fibers, films, and surface coatings. Despite its low toxicity level, DMAc can still pose health hazards such as skin, eye, respiratory irritations and it is highly flammable.

Check Digit Verification of cas no

The CAS Registry Mumber 127-19-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 7 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 127-19:
(5*1)+(4*2)+(3*7)+(2*1)+(1*9)=45
45 % 10 = 5
So 127-19-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H9NO/c1-3(2)4(5)6/h3H,1-2H3,(H2,5,6)

127-19-5 Well-known Company Product Price

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  • Alfa Aesar

  • (22916)  N,N-Dimethylacetamide, HPLC Grade, 99.5+%   

  • 127-19-5

  • 1L

  • 432.0CNY

  • Detail
  • Alfa Aesar

  • (22916)  N,N-Dimethylacetamide, HPLC Grade, 99.5+%   

  • 127-19-5

  • 2500ml

  • 850.0CNY

  • Detail
  • Alfa Aesar

  • (22916)  N,N-Dimethylacetamide, HPLC Grade, 99.5+%   

  • 127-19-5

  • 4L

  • 1281.0CNY

  • Detail
  • Alfa Aesar

  • (22916)  N,N-Dimethylacetamide, HPLC Grade, 99.5+%   

  • 127-19-5

  • *4x1L

  • 1477.0CNY

  • Detail
  • Alfa Aesar

  • (44913)  N,N-Dimethylacetamide, anhydrous, 99.8%, packaged under Argon in resealable ChemSeal? bottles   

  • 127-19-5

  • 100ml

  • 300.0CNY

  • Detail
  • Alfa Aesar

  • (44913)  N,N-Dimethylacetamide, anhydrous, 99.8%, packaged under Argon in resealable ChemSeal? bottles   

  • 127-19-5

  • *4x100ml

  • 793.0CNY

  • Detail
  • Alfa Aesar

  • (44913)  N,N-Dimethylacetamide, anhydrous, 99.8%, packaged under Argon in resealable ChemSeal? bottles   

  • 127-19-5

  • 1L

  • 956.0CNY

  • Detail
  • Alfa Aesar

  • (A10924)  N,N-Dimethylacetamide, 99%   

  • 127-19-5

  • 250ml

  • 232.0CNY

  • Detail
  • Alfa Aesar

  • (A10924)  N,N-Dimethylacetamide, 99%   

  • 127-19-5

  • 500ml

  • 264.0CNY

  • Detail
  • Alfa Aesar

  • (A10924)  N,N-Dimethylacetamide, 99%   

  • 127-19-5

  • 2500ml

  • 1052.0CNY

  • Detail
  • Riedel-de Haën

  • (44901)  N,N-Dimethylacetamide  CHROMASOLV®, GC-Headspace tested, ≥99.9%

  • 127-19-5

  • 44901-1L

  • 1,614.60CNY

  • Detail
  • Sigma-Aldrich

  • (270555)  N,N-Dimethylacetamide  for HPLC, ≥99.9%

  • 127-19-5

  • 270555-1L

  • 1,469.52CNY

  • Detail

127-19-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name N,N-dimethylacetamide

1.2 Other means of identification

Product number -
Other names N,N-Dimethylacetamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. CBI,Finishing agents,Intermediates,Processing aids, not otherwise listed,Solvents (which become part of product formulation or mixture)
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:127-19-5 SDS

127-19-5Synthetic route

carbon monoxide
201230-82-2

carbon monoxide

tertamethylammonium iodide
75-58-1

tertamethylammonium iodide

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride In 1-methyl-pyrrolidin-2-one at 190℃; for 6h; Catalytic behavior; Solvent; Time; Reagent/catalyst; Concentration;99.1%
With cobalt(II) chloride; sodium sulfite; zinc In 1-methyl-pyrrolidin-2-one at 200℃; under 22502.3 Torr; for 7h; Solvent; Reagent/catalyst; Temperature; Pressure; Autoclave;98.5%
With palladium dichloride In 1-methyl-pyrrolidin-2-one at 190℃; for 8h; Catalytic behavior; Temperature; Pressure;
dimethyl amine
124-40-3

dimethyl amine

acetyl chloride
75-36-5

acetyl chloride

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

Conditions
ConditionsYield
With self-zirconium modification of the nanoscale solid alkali catalyst In diethyl ether at 20℃; for 5h; Inert atmosphere;98.5%
In diethyl ether20%
With diethyl ether
In tetrahydrofuran; dichloromethane at 20℃; Cooling with ice;
With triethylamine In dichloromethane at 20℃; for 12h;
carbon monoxide
201230-82-2

carbon monoxide

trimethylamine
75-50-3

trimethylamine

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

Conditions
ConditionsYield
With tertamethylammonium iodide; palladium dichloride In 1-methyl-pyrrolidin-2-one at 20 - 240℃; under 7500.75 - 48754.9 Torr; for 1.96667h; Product distribution / selectivity; Autoclave;97%
2-Dimethylamino-3-methyl-2,4,6-triphenyl-2H-pyran
79962-35-9

2-Dimethylamino-3-methyl-2,4,6-triphenyl-2H-pyran

A

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

B

3-Methyl-2,4,6-triphenylpyryliumchlorid
92919-44-3

3-Methyl-2,4,6-triphenylpyryliumchlorid

Conditions
ConditionsYield
With acetyl chloride In diethyl ether for 1h; Heating;A 32%
B 94%
2-Dimethylamino-3-methyl-2,4,6-triphenyl-2H-pyran
79962-35-9

2-Dimethylamino-3-methyl-2,4,6-triphenyl-2H-pyran

acetyl chloride
75-36-5

acetyl chloride

A

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

B

3-Methyl-2,4,6-triphenylpyryliumchlorid
92919-44-3

3-Methyl-2,4,6-triphenylpyryliumchlorid

Conditions
ConditionsYield
In diethyl ether for 1h; Heating;A 32%
B 94%
ethyl acetate
141-78-6

ethyl acetate

dimethyl amine
124-40-3

dimethyl amine

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

Conditions
ConditionsYield
With [Zn(BH4)2(py)] In tetrahydrofuran for 0.34h; Heating;93%
N-methyl ephedrine

N-methyl ephedrine

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

Conditions
ConditionsYield
With potassium hydroxide; air In diethyl ether at 20℃; for 90h;92%
carbon monoxide
201230-82-2

carbon monoxide

tertamethylammonium iodide
75-58-1

tertamethylammonium iodide

trimethylamine
75-50-3

trimethylamine

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

Conditions
ConditionsYield
With [2,2]bipyridinyl; palladium dichloride In 1-methyl-pyrrolidin-2-one at 20 - 200℃; under 22502.3 Torr; for 8h; Reagent/catalyst; Time; Autoclave;90.8%
metamfepramone
15351-09-4

metamfepramone

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

Conditions
ConditionsYield
With potassium hydroxide; air In diethyl ether at 20℃; for 30h;90%
N,N-Dimethylcarbamidsaeure-trimethylsilylester
32115-55-2

N,N-Dimethylcarbamidsaeure-trimethylsilylester

acetyl chloride
75-36-5

acetyl chloride

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

Conditions
ConditionsYield
In dichloromethane for 0.25h; Ambient temperature;87%
2-acetoxy-3,3-dimethyl-but-1-ene
3840-71-9

2-acetoxy-3,3-dimethyl-but-1-ene

(t-C4H9)2SbN(CH3)2
30364-05-7

(t-C4H9)2SbN(CH3)2

A

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

B

(t-C4H9)2SbCH2COC(CH3)3
53742-78-2

(t-C4H9)2SbCH2COC(CH3)3

Conditions
ConditionsYield
under Ar, at 80-90°C, 4 h;A n/a
B 85%
(t-C4H9)2SbN(CH3)2
30364-05-7

(t-C4H9)2SbN(CH3)2

1-cyclohexenyl acetate
1424-22-2

1-cyclohexenyl acetate

A

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

B

(t-C4H9)2SbOC6H9
53742-83-9

(t-C4H9)2SbOC6H9

Conditions
ConditionsYield
under Ar, at 80-90°C, 4 h;A n/a
B 79%
3-acetoxy-2-pentene
13893-75-9

3-acetoxy-2-pentene

(t-C4H9)2SbN(CH3)2
30364-05-7

(t-C4H9)2SbN(CH3)2

A

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

B

(t-C4H9)2SbOC(C2H5)CHCH3
53742-80-6, 53742-81-7

(t-C4H9)2SbOC(C2H5)CHCH3

C

(t-C4H9)2SbCH(CH3)COC2H5
53742-82-8

(t-C4H9)2SbCH(CH3)COC2H5

Conditions
ConditionsYield
under Ar, at 80-90°C, 4 h;A n/a
B n/a
C 78%
under argon, at 80-90°C for 4 h, vac. distn.;
N,N-Dimethylacetoacetamid
2044-64-6

N,N-Dimethylacetoacetamid

1,3-Dichloro-2-butene
10075-38-4

1,3-Dichloro-2-butene

A

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

B

N,N-dimethyl-5-chloro-4-hexenamide

N,N-dimethyl-5-chloro-4-hexenamide

C

N,N-dimethyl-α-(3-chloro-2-butenyl)acetoacetamide
83305-52-6

N,N-dimethyl-α-(3-chloro-2-butenyl)acetoacetamide

Conditions
ConditionsYield
With potassium hydroxide; Katamin AB at 100℃; for 40h;A 2.8%
B 1.1%
C 75%
2-(dimethylamino)propan-1-ol
15521-18-3

2-(dimethylamino)propan-1-ol

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

Conditions
ConditionsYield
With potassium hydroxide; air In diethyl ether at 20℃; for 90h;73%
acetic acid hydrazide
1068-57-1

acetic acid hydrazide

N,N-Dimethyl-N'-(dimethylamino-methoxymethyl)-formamidin

N,N-Dimethyl-N'-(dimethylamino-methoxymethyl)-formamidin

A

1,2,4-Triazole
288-88-0

1,2,4-Triazole

B

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

Conditions
ConditionsYield
In methanol for 8h; Heating;A 71%
B 52%
2-oxo-2-dimethylamino-4-methyl-1,3,2-dioxaphosphorinane
21857-33-0

2-oxo-2-dimethylamino-4-methyl-1,3,2-dioxaphosphorinane

A

2-chloro-2-oxo-2-mercapto-4-methyl-1,3,2-dioxaphosphorinane
31951-90-3

2-chloro-2-oxo-2-mercapto-4-methyl-1,3,2-dioxaphosphorinane

B

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

Conditions
ConditionsYield
With acetyl chloride In benzene for 1h; Heating;A n/a
B 70%
N,N,N,N,N,N-hexamethylphosphoric triamide
680-31-9

N,N,N,N,N,N-hexamethylphosphoric triamide

A

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

B

N,N,N',N'-Tetramethylphosphorodiamidic chloride
1605-65-8

N,N,N',N'-Tetramethylphosphorodiamidic chloride

Conditions
ConditionsYield
With acetyl chloride In benzene for 1h; Heating;A n/a
B 67%
4-chloropropiophenone enol acetate
159924-61-5

4-chloropropiophenone enol acetate

(t-C4H9)2SbN(CH3)2
30364-05-7

(t-C4H9)2SbN(CH3)2

A

(t-C4H9)2SbCH(CH3)COC6H4-4-Cl
54266-19-2

(t-C4H9)2SbCH(CH3)COC6H4-4-Cl

B

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

C

(t-C4H9)2SbOC(C6H4-4-Cl)CHCH3
54266-17-0, 54266-18-1

(t-C4H9)2SbOC(C6H4-4-Cl)CHCH3

Conditions
ConditionsYield
under Ar, at 80-90°C, 8 h;A 66%
B n/a
C n/a
carbon monoxide
201230-82-2

carbon monoxide

tetramethylammonium bromide
64-20-0

tetramethylammonium bromide

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

Conditions
ConditionsYield
With sodium tetracarbonyl cobaltate In 1-methyl-pyrrolidin-2-one at 200℃; under 22502.3 Torr; for 14h; Autoclave;64.5%
With palladium dichloride In 1-methyl-pyrrolidin-2-one at 190℃; for 12h; Catalytic behavior;
(t-C4H9)2SbN(CH3)2
30364-05-7

(t-C4H9)2SbN(CH3)2

1-acetoxycyclopentene
933-06-2

1-acetoxycyclopentene

A

C13H25OSb
43106-62-3

C13H25OSb

B

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

C

(t-C4H9)2SbOC5H7
43106-63-4

(t-C4H9)2SbOC5H7

Conditions
ConditionsYield
under Ar, at 80-90°C, 4 h;A 64%
B n/a
C n/a
N,N-dimethylthioacetamide
631-67-4

N,N-dimethylthioacetamide

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

Conditions
ConditionsYield
With triphenyltin(IV) hydroxide In benzene-d6 at 90℃; for 36h;64%
With 6H(1+)*Mo9O40PV3(6-); oxygen In acetonitrile at 60℃; under 760.051 Torr; for 2h; Inert atmosphere; Glovebox;53 %Chromat.
maleiimide
541-59-3

maleiimide

2-dimethylamino-5-ethyl-4-methyloxazole
313263-46-6

2-dimethylamino-5-ethyl-4-methyloxazole

A

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

B

7-ethyl-6-methyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,4-c]pyridine-1,3,4-trione

7-ethyl-6-methyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,4-c]pyridine-1,3,4-trione

Conditions
ConditionsYield
In acetic acid for 3h; Cyclization; ring cleavage; Heating;A n/a
B 63%
1,1,1-triethyl-N,N-dimethylsilylamine
3550-35-4

1,1,1-triethyl-N,N-dimethylsilylamine

trimethylsilyl acetate
2754-27-0

trimethylsilyl acetate

A

Hexamethyldisiloxane
107-46-0

Hexamethyldisiloxane

B

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

C

1,1,1-triethyl-3,3,3-trimethyl-disiloxane
2652-41-7

1,1,1-triethyl-3,3,3-trimethyl-disiloxane

D

hexaethyl disiloxane
994-49-0

hexaethyl disiloxane

Conditions
ConditionsYield
With N-Methylformamide at 50 - 75℃; for 21h;A n/a
B 60%
C n/a
D n/a
With N-Methylformamide at 50 - 75℃; for 21h; Product distribution; Mechanism; other amides as catalysts;A n/a
B 60%
C n/a
D n/a
1,1,1-triethyl-N,N-dimethylsilylamine
3550-35-4

1,1,1-triethyl-N,N-dimethylsilylamine

A

Hexamethyldisiloxane
107-46-0

Hexamethyldisiloxane

B

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

C

1,1,1-triethyl-3,3,3-trimethyl-disiloxane
2652-41-7

1,1,1-triethyl-3,3,3-trimethyl-disiloxane

D

hexaethyl disiloxane
994-49-0

hexaethyl disiloxane

Conditions
ConditionsYield
With N-Methylformamide; trimethylsilyl acetate at 50 - 75℃; for 21h;A n/a
B 60%
C n/a
D n/a
trimethylsilyl acetate
2754-27-0

trimethylsilyl acetate

A

Hexamethyldisiloxane
107-46-0

Hexamethyldisiloxane

B

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

C

1,1,1-triethyl-3,3,3-trimethyl-disiloxane
2652-41-7

1,1,1-triethyl-3,3,3-trimethyl-disiloxane

D

hexaethyl disiloxane
994-49-0

hexaethyl disiloxane

Conditions
ConditionsYield
With N-Methylformamide; 1,1,1-triethyl-N,N-dimethylsilylamine at 50 - 75℃; for 21h;A n/a
B 60%
C n/a
D n/a
2-methyl-1-phenyl-1-acetoxy-1-propene
5170-76-3

2-methyl-1-phenyl-1-acetoxy-1-propene

(t-C4H9)2SbN(CH3)2
30364-05-7

(t-C4H9)2SbN(CH3)2

A

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

B

(t-C4H9)2SbOC(C6H5)C(CH3)2
54266-23-8

(t-C4H9)2SbOC(C6H5)C(CH3)2

Conditions
ConditionsYield
under Ar, at 80-90°C, 8 h;A n/a
B 58%
acetic acid
64-19-7

acetic acid

tris(dimethylamino)selenonium chloride

tris(dimethylamino)selenonium chloride

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

Conditions
ConditionsYield
In dichloromethane for 5h;57%
1-phenylprop-1-enyl acetate
39623-95-5

1-phenylprop-1-enyl acetate

(t-C4H9)2SbN(CH3)2
30364-05-7

(t-C4H9)2SbN(CH3)2

A

(t-C4H9)2SbCH(CH3)COC6H5
54266-13-6

(t-C4H9)2SbCH(CH3)COC6H5

B

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

C

(t-C4H9)2SbOC(C6H5)CHCH3
54266-11-4, 54266-12-5

(t-C4H9)2SbOC(C6H5)CHCH3

Conditions
ConditionsYield
under Ar, at 80-90°C, 8 h;A 57%
B n/a
C n/a
under argon, at 80-90°C, 8 h;
trans-geranyl bromide
6138-90-5

trans-geranyl bromide

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

Geranylessigsaeure-N,N-dimethylamid
89171-32-4

Geranylessigsaeure-N,N-dimethylamid

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide In tetrahydrofuran at -78℃;100%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

4-bromobenzenecarbonitrile
623-00-7

4-bromobenzenecarbonitrile

2-(4-cyanophenyl)-N,N-dimethylacetamide
79149-55-6

2-(4-cyanophenyl)-N,N-dimethylacetamide

Conditions
ConditionsYield
With potassium In ammonia100%
Stage #1: N,N-dimethyl acetamide With sec.-butyllithium In tetrahydrofuran; cyclohexane at -78℃; for 1h;
Stage #2: With zinc(II) chloride In tetrahydrofuran; cyclohexane at 20℃; for 0.166667h;
Stage #3: 4-bromobenzenecarbonitrile With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran; cyclohexane at 20℃; for 4h;
89%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

4-Methoxy-8-hydroxynaphthyl 4-methoxyphenyl ketone

4-Methoxy-8-hydroxynaphthyl 4-methoxyphenyl ketone

8-Dimethylamino-3-methoxy-10-(4-methoxy-phenyl)-7-oxonia-cyclohepta[de]naphthalene; perchlorate

8-Dimethylamino-3-methoxy-10-(4-methoxy-phenyl)-7-oxonia-cyclohepta[de]naphthalene; perchlorate

Conditions
ConditionsYield
With perchloric acid; trichlorophosphate at 60 - 70℃;100%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

trimethylsilyl trifluoromethanesulfonate
27607-77-8

trimethylsilyl trifluoromethanesulfonate

dimethyl-N-(1-trimethylsilyloxy-1-methylmethylidene)ammonium trifluoromethanesulfonate

dimethyl-N-(1-trimethylsilyloxy-1-methylmethylidene)ammonium trifluoromethanesulfonate

Conditions
ConditionsYield
at 20℃; for 0.0833333h;100%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

D-3,6-di-O-trifluoromethanesulfonyl-1,2:4,5-di-O-isopropylidene-myo-inositol
685539-87-1

D-3,6-di-O-trifluoromethanesulfonyl-1,2:4,5-di-O-isopropylidene-myo-inositol

(D)-2,5-di-O-acetyl-1,6:3,4-di-O-isopropylidene-allo-inositol
685539-88-2

(D)-2,5-di-O-acetyl-1,6:3,4-di-O-isopropylidene-allo-inositol

Conditions
ConditionsYield
With potassium acetate at 70℃;100%
2,5-dibromopyridine
624-28-2

2,5-dibromopyridine

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

1-(5-bromopyridin-2-yl)ethanone
214701-49-2

1-(5-bromopyridin-2-yl)ethanone

Conditions
ConditionsYield
With n-butyllithium In hexane; toluene at -40 - 20℃; for 2h; Inert atmosphere;100%
Stage #1: 2,5-dibromopyridine With n-butyllithium In hexane; toluene at -40℃; for 0.666667h;
Stage #2: N,N-dimethyl acetamide In hexane; toluene at 20℃; for 1h; Further stages.;
83%
Stage #1: 2,5-dibromopyridine With n-butyllithium In toluene Inert atmosphere;
Stage #2: N,N-dimethyl acetamide In toluene Inert atmosphere;
83%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

C13H10N2O4S
331811-71-3

C13H10N2O4S

N,N-dimethyl-3-phenyl-3-(2-nitrobenezenesulfonylamino)propanamide
1296241-25-2

N,N-dimethyl-3-phenyl-3-(2-nitrobenezenesulfonylamino)propanamide

Conditions
ConditionsYield
With triisopropylsilyl trifluoromethanesulfonate; triethylamine In toluene at 20℃; for 12h; Mannich type reaction;100%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

N-(benzylidene)-p-methylbenzenesulfonamide
51608-60-7

N-(benzylidene)-p-methylbenzenesulfonamide

N,N-dimethyl-3-((4-methylphenyl)sulfonamido)-3-phenylpropanamide
1061233-61-1

N,N-dimethyl-3-((4-methylphenyl)sulfonamido)-3-phenylpropanamide

Conditions
ConditionsYield
With triisopropylsilyl trifluoromethanesulfonate; triethylamine In toluene at 20℃; for 12h; Mannich type reaction;100%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

4-methyl-N-(3-nitrobenzylidene)benzenesulfonamide
73845-02-0

4-methyl-N-(3-nitrobenzylidene)benzenesulfonamide

N,N-dimethyl-3-(3-nitrophenyl)-3-(tosylamino)propanamide
1262117-69-0

N,N-dimethyl-3-(3-nitrophenyl)-3-(tosylamino)propanamide

Conditions
ConditionsYield
With triisopropylsilyl trifluoromethanesulfonate; triethylamine In toluene at 20℃; for 12h; Mannich type reaction;100%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

N-(p-chlorobenzylidene)-p-toluenesulfonamide
3157-65-1

N-(p-chlorobenzylidene)-p-toluenesulfonamide

3-(4-chlorophenyl)-N,N-dimethyl-3-(tosylamino)propanamide
1262117-67-8

3-(4-chlorophenyl)-N,N-dimethyl-3-(tosylamino)propanamide

Conditions
ConditionsYield
With triisopropylsilyl trifluoromethanesulfonate; triethylamine In toluene at 20℃; for 12h; Mannich type reaction;100%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

N-(2-naphthylidene)-4-methylbenzenesulfonamide
17692-84-1

N-(2-naphthylidene)-4-methylbenzenesulfonamide

N,N-dimethyl-3-(naphthalen-2-yl)-3-(tosylamino)propanamide
1262117-71-4

N,N-dimethyl-3-(naphthalen-2-yl)-3-(tosylamino)propanamide

Conditions
ConditionsYield
With triisopropylsilyl trifluoromethanesulfonate; triethylamine In toluene at 20℃; for 12h; Mannich type reaction;100%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

N-(2,2-dimethylpropylidene)-p-toluenesulfonamide
135822-92-3

N-(2,2-dimethylpropylidene)-p-toluenesulfonamide

N,N,4,4-tetramethyl-3-(tosylamino)pentanamide
1262117-74-7

N,N,4,4-tetramethyl-3-(tosylamino)pentanamide

Conditions
ConditionsYield
With triisopropylsilyl trifluoromethanesulfonate; triethylamine In toluene at 20℃; for 12h; Mannich type reaction;100%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

N-cyclopropylmethylene-4-methyl-benzenesulfonamide

N-cyclopropylmethylene-4-methyl-benzenesulfonamide

3-cyclopropyl-N,N-dimethyl-3-(tosylamino)propanamide
1262117-75-8

3-cyclopropyl-N,N-dimethyl-3-(tosylamino)propanamide

Conditions
ConditionsYield
With triisopropylsilyl trifluoromethanesulfonate; triethylamine In toluene at 20℃; for 12h; Mannich type reaction;100%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

C26H44N2O3
1214742-49-0

C26H44N2O3

C27H44N2O4
1191073-29-6

C27H44N2O4

Conditions
ConditionsYield
Stage #1: N,N-dimethyl acetamide With trichlorophosphate at 0 - 5℃; for 1h;
Stage #2: C26H44N2O3 In ISOPROPYLAMIDE; water at 10℃; for 2h;
Stage #3: With sodium hydroxide In ISOPROPYLAMIDE; water at 20℃; for 2h; pH=9 - 10;
100%
3-bromo-4-methyl-5-nitro-6-methoxypyridine
884495-14-1

3-bromo-4-methyl-5-nitro-6-methoxypyridine

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

(E)-2-(5-bromo-2-methoxy-3-nitropyridin-4-yl)-N,N-dimethylethylene-1-amine

(E)-2-(5-bromo-2-methoxy-3-nitropyridin-4-yl)-N,N-dimethylethylene-1-amine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 80 - 95℃; for 5h;100%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

[Co(H2O)6][bis(trifluoromethylsulfonyl)imide]2

[Co(H2O)6][bis(trifluoromethylsulfonyl)imide]2

[Co(N,N-dimethylacetamide)6][bis(trifluoromethylsulfonyl)imide]2

[Co(N,N-dimethylacetamide)6][bis(trifluoromethylsulfonyl)imide]2

Conditions
ConditionsYield
In ethanol for 0.0833333h;100%
p-phenylpyridine
939-23-1

p-phenylpyridine

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

{[Cu2(1-(4-{[4-(3-oxo-3-phenylpropanoyl)phenyl]methyl}phenyl)-3-phenylpropane-1,3-dione)2](4,4’-bipyridine)}n

{[Cu2(1-(4-{[4-(3-oxo-3-phenylpropanoyl)phenyl]methyl}phenyl)-3-phenylpropane-1,3-dione)2](4,4’-bipyridine)}n

{[Cu2(1-(4-{[4-(3-oxo-3-phenylpropanoyl)phenyl]methyl}phenyl)-3-phenylpropane-1,3-dione)2](DMA)(4-phenylpyridine)}

{[Cu2(1-(4-{[4-(3-oxo-3-phenylpropanoyl)phenyl]methyl}phenyl)-3-phenylpropane-1,3-dione)2](DMA)(4-phenylpyridine)}

Conditions
ConditionsYield
In diethyl ether100%
p-phenylpyridine
939-23-1

p-phenylpyridine

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

{[Cu2(1-(4-{[4-(3-oxo-3-phenylpropanoyl)phenyl]methyl}phenyl)-3-phenylpropane-1,3-dione)2](pyridine)2}

{[Cu2(1-(4-{[4-(3-oxo-3-phenylpropanoyl)phenyl]methyl}phenyl)-3-phenylpropane-1,3-dione)2](pyridine)2}

{[Cu2(1-(4-{[4-(3-oxo-3-phenylpropanoyl)phenyl]methyl}phenyl)-3-phenylpropane-1,3-dione)2](DMA)(4-phenylpyridine)}

{[Cu2(1-(4-{[4-(3-oxo-3-phenylpropanoyl)phenyl]methyl}phenyl)-3-phenylpropane-1,3-dione)2](DMA)(4-phenylpyridine)}

Conditions
ConditionsYield
In diethyl ether100%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

[Cu2(1-(4-{[4-(3-oxo-3-phenylpropanoyl)phenyl]methyl}phenyl)-3-phenylpropane-1,3-dione)2]

[Cu2(1-(4-{[4-(3-oxo-3-phenylpropanoyl)phenyl]methyl}phenyl)-3-phenylpropane-1,3-dione)2]

{[Cu2(1-(4-{[4-(3-oxo-3-phenylpropanoyl)phenyl]methyl}phenyl)-3-phenylpropane-1,3-dione)2](DMA)2}

{[Cu2(1-(4-{[4-(3-oxo-3-phenylpropanoyl)phenyl]methyl}phenyl)-3-phenylpropane-1,3-dione)2](DMA)2}

Conditions
ConditionsYield
at 50℃; for 1h;100%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

(3S)-7-amino-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxine-6-carbonitrile

(3S)-7-amino-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxine-6-carbonitrile

N'-[(2S)-7-cyano-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]N,N-dimethylmethanimidamide

N'-[(2S)-7-cyano-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]N,N-dimethylmethanimidamide

Conditions
ConditionsYield
With acetic acid In N,N-dimethyl-formamide; toluene at 105℃; for 3h;100%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

ethyl acetoacetate
141-97-9

ethyl acetoacetate

ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate
134653-70-6, 51145-57-4

ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate

Conditions
ConditionsYield
In ethanol; N,N-dimethyl-formamide at 60℃; for 2h;100%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

2-(bromomethyl)-4-fluorothiophene

2-(bromomethyl)-4-fluorothiophene

1-(4-fluorothiophen-2-yl)-N,N-dimethylmethanamine

1-(4-fluorothiophen-2-yl)-N,N-dimethylmethanamine

Conditions
ConditionsYield
With butoxytributylazanium sulfate In chloroform at 60℃; for 2h;99.5%
Cyclopropyl methyl ketone
765-43-5

Cyclopropyl methyl ketone

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

2-cyclopropyl-2-oxoethyl acetate
89898-26-0

2-cyclopropyl-2-oxoethyl acetate

Conditions
ConditionsYield
Stage #1: Cyclopropyl methyl ketone; N,N-dimethyl acetamide With trifluorormethanesulfonic acid; thallium(III) acetate at 60℃; for 0.333333h;
Stage #2: With water for 0.166667h; Further stages.;
99%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

4-benzyloxypropiophenone
4495-66-3

4-benzyloxypropiophenone

Acetic acid 2-(4-benzyloxy-phenyl)-1-methyl-2-oxo-ethyl ester
200353-85-1

Acetic acid 2-(4-benzyloxy-phenyl)-1-methyl-2-oxo-ethyl ester

Conditions
ConditionsYield
Stage #1: N,N-dimethyl acetamide; 4-benzyloxypropiophenone With trifluorormethanesulfonic acid; thallium(III) acetate at 60℃; for 0.333333h;
Stage #2: With water for 0.166667h; Further stages.;
99%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

cyclohexanone
108-94-1

cyclohexanone

2-acetoxycyclohexanone
17472-04-7

2-acetoxycyclohexanone

Conditions
ConditionsYield
Stage #1: N,N-dimethyl acetamide; cyclohexanone With trifluorormethanesulfonic acid; thallium(III) acetate at 60℃; for 0.333333h;
Stage #2: With water for 0.166667h; Further stages.;
99%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

inden-1-one
83-33-0

inden-1-one

2-acetoxyindan-1-one
1579-15-3

2-acetoxyindan-1-one

Conditions
ConditionsYield
Stage #1: N,N-dimethyl acetamide; inden-1-one With trifluorormethanesulfonic acid; thallium(III) acetate at 60℃; for 0.333333h;
Stage #2: With water for 0.166667h; Further stages.;
99%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

cyclopentanone
120-92-3

cyclopentanone

2-acetoxycyclopentanone
52789-75-0

2-acetoxycyclopentanone

Conditions
ConditionsYield
Stage #1: N,N-dimethyl acetamide; cyclopentanone With trifluorormethanesulfonic acid; thallium(III) acetate at 60℃; for 0.333333h;
Stage #2: With water for 0.166667h; Further stages.;
99%
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

[chloro-(p-tolylsulfinyl)methylidene]cyclopentadecane
172467-97-9

[chloro-(p-tolylsulfinyl)methylidene]cyclopentadecane

2-{1-[chloro(p-tolylsulfinyl)methyl]cyclopentadecyl}-N,N-dimethylacetamide
823213-54-3

2-{1-[chloro(p-tolylsulfinyl)methyl]cyclopentadecyl}-N,N-dimethylacetamide

Conditions
ConditionsYield
Stage #1: N,N-dimethyl acetamide With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.166667h;
Stage #2: [chloro-(p-tolylsulfinyl)methylidene]cyclopentadecane In tetrahydrofuran at -78 - -50℃; for 0.666667h; Further stages.;
99%
Stage #1: N,N-dimethyl acetamide With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.166667h;
Stage #2: [chloro-(p-tolylsulfinyl)methylidene]cyclopentadecane In tetrahydrofuran at -78℃; for 3h;
N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

D-3-O-trifluoromethanesulfonyl-1,2:4,5-di-O-isopropylidene-myo-inositol
685539-84-8

D-3-O-trifluoromethanesulfonyl-1,2:4,5-di-O-isopropylidene-myo-inositol

1L-1-O-acetyl-2,3:5,6-di-O-isopropylidene-chiro-inositol
685539-85-9

1L-1-O-acetyl-2,3:5,6-di-O-isopropylidene-chiro-inositol

Conditions
ConditionsYield
With potassium acetate at 70℃;99%

127-19-5Related news

Full Length ArticleThermophysical study of the binary mixtures of N,N-Dimethylacetamide (cas 127-19-5) with 2-propanol and 2-butanol09/30/2019

This work reports thermophysical properties measurements of binary mixtures of N,N-dimethylacetamide with 2-propanol and 2-butanol. Density, ρ, speed of sound, u, refractive index, nD, and kinematic viscosity, ν, were measured over the whole composition range at the temperatures (283.15, 298.1...detailed

Solvation of alkaline earth metal ions in N,N-dimethylformamide and N,N-Dimethylacetamide (cas 127-19-5) – A volumetric and acoustic study09/29/2019

Densities and sound velocities at temperatures (298.15, 303.15, 308.15, 313.15 and 318.15) K of magnesium(II), calcium(II) and strontium(II) trifluoromethanesulfonates (triflates), as well as barium(II) perchlorate in N,N-dimethylformamide (dmf) and N,N-dimethylacetamide (dma) have been measured...detailed

Thermodynamics of amide + amine mixtures. 5. excess molar enthalpies of N,N-dimethylformamide or N,N-Dimethylacetamide (cas 127-19-5) + N-propylpropan-1-amine, + N-butylbutan-1-amine, + butan-1-amine, or + hexan-1-amine systems at 298.15 K. application of the ERAS model09/28/2019

Excess molar enthalpies, HmE, over the whole composition range have been determined for the liquid mixtures N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMA) + butan-1-amine (BA), or + hexan-1-amine (HxA), or + N-propylpropan-1-amine (DPA), or N-butylbutan-1-amine (DBA) at 298.15 K and ...detailed

Thermophysical study of the binary mixtures of N,N-Dimethylacetamide (cas 127-19-5) with 1-propanol and 1-butanol09/26/2019

Several thermophysical properties such as densities, ρ, speeds of sound, u, refractive indices, nD, and kinematic viscosities, ν, have been measured for the binary mixtures of N,N-Dimethylacetamide with 1-propanol and 1-butanol over the entire range of composition, at the temperatures (283.15,...detailed

Convenient N-acetylation of amines in N,N-Dimethylacetamide (cas 127-19-5) with N,N-carbonyldiimidazole09/24/2019

Dimethylacetamide (DMAc) acts as an efficient source of acetyl and dimethylamine gas in the presence of N,N-carbonyldiimidazole (CDI). Addition of amines to the reaction mixture delivers the corresponding amides in good to excellent yields. The acetylation of amines reported herein, which relies...detailed

Solvation of ionic liquids based on N-methyl-N-alkylmorpholinium cations in N,N-dimethylformamide and N,N-Dimethylacetamide (cas 127-19-5) – Volumetric and compressibility studies09/10/2019

Density and sound velocity of the solutions of ionic liquids based on N-alkyl-N-methyl- morpholinium cations: N-ethyl-N-methylmorpholinium bis(trifluoromethanesulfonyl)imide, N-butyl-N-methylmorpholinium bis(trifluoromethanesulfonyl)imide, N-octyl-N-methyl -morpholinium bis(trifluoromethanesulfo...detailed

127-19-5Relevant articles and documents

Lewis Acidic Boranes, Lewis Bases, and Equilibrium Constants: A Reliable Scaffold for a Quantitative Lewis Acidity/Basicity Scale

Mayer, Robert J.,Hampel, Nathalie,Ofial, Armin R.

supporting information, p. 4070 - 4080 (2021/01/29)

A quantitative Lewis acidity/basicity scale toward boron-centered Lewis acids has been developed based on a set of 90 experimental equilibrium constants for the reactions of triarylboranes with various O-, N-, S-, and P-centered Lewis bases in dichloromethane at 20 °C. Analysis with the linear free energy relationship log KB=LAB+LBB allows equilibrium constants, KB, to be calculated for any type of borane/Lewis base combination through the sum of two descriptors, one for Lewis acidity (LAB) and one for Lewis basicity (LBB). The resulting Lewis acidity/basicity scale is independent of fixed reference acids/bases and valid for various types of trivalent boron-centered Lewis acids. It is demonstrated that the newly developed Lewis acidity/basicity scale is easily extendable through linear relationships with quantum-chemically calculated or common physical–organic descriptors and known thermodynamic data (ΔH (Formula presented.)). Furthermore, this experimental platform can be utilized for the rational development of borane-catalyzed reactions.

METHOD FOR PRODUCING N,N-DISUBSTITUTED AMIDE AND CATALYST FOR PRODUCING N,N-DISUBSTITUTED AMIDE

-

Page/Page column 0055-0079, (2020/04/01)

To provide a method for producing an N, N-disubstituted amide in which an N,N-disubstituted amide can be obtained by a reaction of a nitrile and an alcohol even by a liquid phase reaction and a gas phase reaction and the object product obtained after the reaction and a catalyst can be easily separated.SOLUTION: There is provided a method for producing an N,N-disubstituted amide by reacting a nitrile and an alcohol in the presence of a catalyst, wherein the catalyst is a heterogeneous catalyst composed of a carrier and a metal oxide carried on the carrier, the carrier is at least one selected from zeolite, silica and alumina and a metal included in the metal oxide includes at least one selected from copper and molybdenum.SELECTED DRAWING: None

Formation of carbon–nitrogen bonds in carbon monoxide electrolysis

Jouny, Matthew,Lv, Jing-Jing,Cheng, Tao,Ko, Byung Hee,Zhu, Jun-Jie,Goddard, William A.,Jiao, Feng

, p. 846 - 851 (2019/09/03)

The electroreduction of CO2 is a promising technology for carbon utilization. Although electrolysis of CO2 or CO2-derived CO can generate important industrial multicarbon feedstocks such as ethylene, ethanol, n-propanol and acetate, most efforts have been devoted to promoting C–C bond formation. Here, we demonstrate that C–N bonds can be formed through co-electrolysis of CO and NH3 with acetamide selectivity of nearly 40% at industrially relevant reaction rates. Full-solvent quantum mechanical calculations show that acetamide forms through nucleophilic addition of NH3 to a surface-bound ketene intermediate, a step that is in competition with OH– addition, which leads to acetate. The C–N formation mechanism was successfully extended to a series of amide products through amine nucleophilic attack on the ketene intermediate. This strategy enables us to form carbon–heteroatom bonds through the electroreduction of CO, expanding the scope of products available from CO2 reduction.

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