1045345-96-7

Upstream product

• 116460-49-2 1-(4-methoxyphenyl)-3-phenylprop-2-yn-1-ol 
• 123-54-6 acetylacetone 
• 536-74-3 phenylacetylene 
• 123-11-5 4-methoxy-benzaldehyde 
• 4440-01-1 lithium phenylacetylide 
• 167688-16-6 1-methoxy-4-(3-phenylprop-2-yn-1-yl)benzene 

Downstream Products

• 1618678-09-3 1-(4-chlorophenyl)-2-methyl-3-acetyl-4-(4-methoxyphenyl)-5-benzyl-1H-pyrrole 

Relevant academic research and scientific papers

AgSbF6-catalyzed efficient propargylation/cycloisomerization tandem reaction for the synthesis of fully substituted furans and new insights into the reaction mechanism

Abstract A mild and efficient AgSbF6 mediated one-pot propargylation/cycloisomerization tandem process has been developed for the construction of fully substituted furans through the reaction of propargylic alcohols and 1,3-dicarbonyl compounds

Propargylation of 1,3-dicarbonyl compounds catalyzed by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and sodium nitrite in the presence of molecular oxygen and formic acid

Catalyzed by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and sodium nitrite, the coupling reaction of 1,3-diarylpropynes and 1,3-dicarbonyl compounds using molecular oxygen as a terminal oxidant was developed. The reaction was promoted dramatically in

HBF4-Catalysed Nucleophilic Substitutions of Propargylic Alcohols

The activity of HBF4 (aqueous solution) as a catalyst in propargylation reactions is presented. Diverse types of nucleophiles were employed in order to form new C-O, C-N and C-C bonds in technical acetone and in air. Good to excellent yields and good chemoselectivities were obtained using low acid loading (typically 1 mol-%) under simple reaction conditions. The activity of HBF4 (aq. solution) as a catalyst in propargylation reactions is presented. C-O, C-N and C-C bonds were formed in technical acetone and in air. Good to excellent yields were obtained using low acid loading (typically 1 mol-%) under mild reaction conditions.

A mild and efficient AgSbF6-catalyzed synthesis of fully substituted pyrroles through a sequential propargylation/amination/ cycloisomerization reaction

Development of an efficient synthesis of fully substituted pyrroles via a sequential propargylation/amination/cycloisomerization was accomplished using AgSbF6 as a catalyst. The one-pot three-component reaction of propargylic alcohols, 1,3-dica

A mild and efficient AgSbF6-catalyzed synthesis of fully substituted pyrroles through a sequential propargylation/amination/cycloisomerization reaction

Development of an efficient synthesis of fully substituted pyrroles via a sequential propargylation/amination/cycloisomerization was accomplished using AgSbF6as a catalyst. The one-pot three-component reaction of propargylic alcohols, 1,3-dicar

Intra- and intermolecular alkylation of N, O-acetals and π-activated alcohols catalyzed by in situ generated acid

Intramolecular and intermolecular alkylations of carbocation precursors of limited ionization ability, principally N,O-acetals, without the use of an exogenous reagent have been developed. The reactions are carried out in 1,1,2,2-tetrachloroethane (TCE) a

Amberlite IR-120H as an efficient and versatile solid phase catalyst for nucleophilic substitution of propargylic alcohols

A highly efficient Amberlite IR-120H resin mediated nucleophilic substitution of the hydroxyl group of propargylic alcohols with a wide range of nucleophiles is reported. The reactions were achieved under very mild conditions in excellent yields.

Inexpensive and efficient synthesis of propargylic substituted active methylene compounds catalyzed by FeCl3

A highly efficient and practical method for the synthesis of propargylic substituted 1,3-dicarbonyl compounds with direct use of propargylic alcohols in the presence of inexpensive and environmentally benign FeCl3 (5mol%) has been presented. Th

Direct substitution of propargylic alcohol with oxygen, nitrogen, and carbon nucleophiles catalyzed by molybdenum(VI)

Efficient and direct substitution of propargylic alcohol with a variety of oxygen, nitrogen, and carbon nucleophiles catalyzed by MoO2(acac)2/NH4PF6 system was developed. The functional alkynes were obtained in modest to good yields with this versatile and practical protocol.

Propargylation of 1,3-dicarbonyl compounds with 1,3-diarylpropynes via oxidative cross-coupling between sp3 C-H and sp3 C-H

(Chemical Equation Presented) A highly efficient oxidative-coupling reaction between diarylpropargylic sp3 C-H and active methylenic sp3 C-H was achieved with DDQ as oxidant. The reaction afforded a direct method for the propargylation of 1,3-dicarbonyl compounds, thus providing a concise synthesis of the corresponding products.