104535-98-0

Upstream product

• 765231-83-2 (E)-3-<2-(4-chlorophenyl)ethylidene>-1-azabicyclo<2.2.2>octane 
• 85093-30-7 diethyl [2-(4-chlorophenyl)ethyl]phosphonate 
• 3731-38-2 3-Quinuclidinone 
• 110473-54-6 (E)-3-<2-(4-chlorophenyl)ethylidene>-1-heptyl-1-azoniabicyclo<2.2.2>octane bromide 

Relevant academic research and scientific papers

Synthesis and cardiac electrophysiological activity of 2- and 3-[(substituted phenyl)alkyl]quinuclidines. Structure-activity relationships

The syntheses and cardiac electrophysiological effects of 21 2- and 3-substituted quinuclidines and some quaternary ammonium derivatives are described. The 2-substituted quinuclidines 2-8 were prepared by alkylation of 2-methylene-3-quinuclidinone. The Wittig reaction with 3-quinuclidinone afforded the 3-substituted derivative 9, which was subsequently converted to 10 and 11. The electrophysiological profiles of the compounds were determined in canine cardiac Purkinje fibers and ventricular muscle strips. The 3-[(substituted phenyl)alkyl]quinuclidines selectively increased action potential duration (Vaughan Williams class III activity). In the 2-substituted series some of the compounds both increased action potential duration and decreased conduction velocity (class I activity). For some of the 2-substituted quinuclidines, appropriate substitution of the phenyl ring was shown to be a requirement for significant class III electrophysiological activity. Selected compounds were efficacious in a programmed electrical stimulation model in the anesthetized dog.

Quinuclidines and quinuclidinium salts as antiarrhythmic agents

Novel quinuclidines, their acid addition, quaternary ammonium and inner salts are described. Also provided is the method of using these compounds as antiarrhythmic agents and pharmaceutical formulations containing such compounds.