85093-30-7

Upstream product

• 637-87-6 1-Chloro-4-iodobenzene 
• 682-30-4 Diethyl vinylphosphonate 
• 122-52-1 triethyl phosphite 
• 5324-30-1 diethyl 2-bromoethylphosphonate 
• 142778-06-1 diethyl (2-iodoethyl)phosphonate 
• 151073-70-0 (4-chloro)phenylzinc iodide 
• 6529-53-9 1-(2-bromoethyl)-4-chlorobenzene 
• 1073-67-2 4-vinylbenzyl chloride 
• 814-49-3 diethyl chlorophosphate 
• 125951-04-4 (E)-diethyl (4-chlorostyryl)phosphonate 

Downstream Products

• 110473-54-6 (E)-3-<2-(4-chlorophenyl)ethylidene>-1-heptyl-1-azoniabicyclo<2.2.2>octane bromide 
• 104535-98-0 3-[2-(4-chlorophenyl)ethyl]-1-heptyl-1-azoniabicyclo[2.2.2]octane bromide 

Relevant academic research and scientific papers

Transition metal-free access to 3,4-dihydro-1,2-oxaphosphinine-2-oxides from phosphonochloridates and chalcones through tandem Michael addition and nucleophilic substitution

A novel and transition metal-free synthesis of 3,4-dihydro-1,2-oxaphosphinine 2-oxides was developed. LiHMDS-mediated tandem Michael addition and nucleophilic substitution of readily available phosphonochloridates and chalcones afforded a variety of valuable 3,4-dihydro-1,2-oxaphosphinine 2-oxides bearing diverse functionalities in excellent yields and satisfactory to good diastereoselectivity (up to 99% yield and up to 99?:?1 dr).

In situ generation of phosphoryl alkylindiums and their synthetic application to arylalkyl phosphonates via palladium-catalyzed cross-coupling reactions

Phosphoryl alkylindium reagents are generated in situ from the direct insertion of indium with bromoalkyl phosphonates in the presence of CuCl, and their synthetic application to arylalkyl phosphonates is reported via a Pd-catalyzed cross-coupling reactio

Rh-catalyzed Negishi alkyl-aryl cross-coupling leading to α- or β-phosphoryl-substituted alkylarenes

The catalytic cross-coupling between ArZnX and ICH2(CH 2)nP(O)(OEt)2 (n = 0-3) has been investigated to determine the utility of the Rh catalyst during the alkyl-aryl cross-coupling and to develop a new syntheti

Metallo-phosphorylation of alkenes: a highly regioselective reaction of zirconocene-alkene complexes with chlorophosphate

Zirconocene-alkene complexes Cp2Zr(CH2{double bond, long}CHR) reacted with chlorophosphate to form zircono-ethylphosphonate with high regioselectivity, which is versatile and could be converted into various functionalized organophosphonates.

Free-Radical Coupling of Alkyl and Aryl Halides with Electron-Deficient Alkenes Mediated by Chromium(II) Complexes

Free radicals generated from organic halides and (ethylenediamine)chromium(II) complexes in DMF are trapped by electron-deficient olefins.The coupling reactions of alkyl halides, described in Part I, are extended and, in addition, aryl halides are shown to be efficient radical precursors to yield coupling products in good yield. Key Words: Bond formation, C-C/ Chromium(II) complexes/ Radicals

Quinuclidines and quinuclidinium salts as antiarrhythmic agents

Novel quinuclidines, their acid addition, quaternary ammonium and inner salts are described. Also provided is the method of using these compounds as antiarrhythmic agents and pharmaceutical formulations containing such compounds.