104541-79-9Relevant academic research and scientific papers
Silica gel and polystyrene supported aluminum chloride as heterogeneous catalysts for the preparation of α-aminophosphonates
Boroujeni, Kaveh Parvanak,Shirazi, Amir Nasrolahi
, p. 418 - 422 (2010)
Silica gel supported aluminum chloride (SiO2-AlCl3) and cross-linked polystyrene-supported aluminum chloride (PS-AlCl3) are environment- friendly heterogeneous catalysts for the condensation of amines and aldehydes with diethyl phosphite to afford α-aminophosphonates. These solid acid catalysts are stable (as bench top catalysts) and can be easily recovered and reused without appreciable change in their efficiency.
Synthesis of α-Aminophosphonates via Phosphonylation of an Aryne-Imine Adduct
Lim, Taehyun,Kim, Byeong Moon
, p. 13246 - 13255 (2020)
Multicomponent phosphonylation is accomplished upon the reaction of an imine with an aryne generated in situ in the presence of a dialkyl phosphite. This transition-metal-free protocol shows a broad substrate scope, providing a variety of α-aminophosphonates in moderate to good yields. A plausible mechanism for the reaction is proposed based on a deuterium exchange experiment.
A simple protocol for the synthesis of α-substituted phosphonates
Wang, Xing,Cai, Yuan,Chen, Jian,Verpoort, Francis
, p. 1268 - 1273 (2016/08/31)
An efficient, easy-to-handle, and mild substitution reaction approach has been developed for the synthesis of phosphonate derivatives, which are very important in the field of industrial, agricultural, and medicinal chemistry. A large number of nucleophiles, including arylamines, alkylamines, heteroarylamines, primary amines and secondary amines, sulfides, and carbides were attempted to react with α-tosyloxyphosphonate 1. The reaction proceeded under catalyst-free and neat conditions and the corresponding phosphonates 2 were afforded in good yields.
Synthesis of α-aminophosphonates using polystyrene supported Al(OTf)3 as a heterogeneous catalyst
Boroujeni, Kaveh Parvanak
experimental part, p. 173 - 176 (2011/04/25)
A mild and efficient method has been devised for the preparation of -aminophosphonates from three component condensation of an aldehyde, an amine, and diethyl phosphite in the presence of catalytic amounts of cross-linked polystyrene supported aluminium triflate (Ps-Al(OTf)3) under solvent-free conditions in good to excellent yields. The catalyst is stable (as a bench top catalyst) and can be easily recovered and reused without appreciable change in its efficiency. Taylor & Francis Group, LLC.
Design and one-pot synthesis of α-aminophosphonates and bis(α-aminophosphonates) by iron(III) chloride and cytotoxic activity
Rezaei, Zahra,Firouzabadi, Habib,Iranpoor, Nasser,Ghaderi, Abbas,Jafari, Mohammad Reza,Jafari, Abbas Ali,Zare, Hamid Reza
experimental part, p. 4266 - 4275 (2009/12/24)
In this study, we used a solution of FeCl3 in THF to facilitate the Mannich-type reaction of aldehyde, amine and phosphite compounds to form corresponding α-aminophosphonates in a one-pot, three-component reaction. Selected α-aminophosphonates
