104561-47-9

Upstream product

• 79158-40-0 diethyl hydroxy(p-tolyl)methylphosphonate 
• 104-87-0 4-methyl-benzaldehyde 
• 3762-25-2 diethyl 4-methylbenzylphosphonate 
• 209626-99-3 (Chloro-p-tolyl-trimethylsilanyl-methyl)-phosphonic acid diethyl ester 

Downstream Products

• 104580-27-0 (5,6,7,8-Tetrahydro-3-methoxy-5,5,8,8-tetramethylnaphth-2-yl)-(4-tolyl)-acetylene 
• 1181811-95-9 diethyl α,α-chlorofluoro-4-methylbenzylphosphonate 

Relevant academic research and scientific papers

The first synthesis of diethyl α,α- chlorofluorobenzylphosphonates

Starting from a-hydroxyphosphonates, a wide variety of diethyl α,α-chlorofluorobenzylphosphonates have been obtained in pure form in a two-step procedure. The first step was chlorination of a- hydroxyphosphonates with Ph3P and CCl4,

Controlled monohalogenation of phosphonates: A new route to pure α- monohalogenated diethyl benzylphosphonates

Starting from diethyl benzylphosphonates, a wide variety of diethyl α- monofluoro, chloro, bromo and iodobenzylphosphonates have been obtained in pure form by a one-pot procedure. This high yielding method implies the intermediate protection of the benzyl anion with TMSCI followed by halogenation with an electrophilic halogenating reagent.

A highly selective synthesis of α-monofluoro- and α-monochloro- benzylphosphonates using eiectrophilic halogenation of benzylphosphonates carbanions

The selective electrophilic monofluorination and monochlorination of a wide variety of diethyl benzylphosphonates have been realized in a one-pot procedure. The monohalogenation was accomplished by intermediate of a benzylic carbanion protected with TMSCl