79158-40-0

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 762-04-9 phosphonic acid diethyl ester 
• 2942-54-3 diethyl (4-methylbenzoyl)phosphonate 
• 122-52-1 triethyl phosphite 
• 2033-24-1 cycl-isopropylidene malonate 
• 762-04-9 Diethyl phosphonate 
• 96258-65-0 diethyl α-trimethylsilyloxy-4-methylbenzylphosphonate 

Downstream Products

• 79158-36-4 diethyl α-fluoro-4-methylbenzylphosphonate 
• 2942-54-3 diethyl (4-methylbenzoyl)phosphonate 
• 26321-53-9 diethyl (phenylamino)(p-tolyl)methylphosphonate 
• 100879-87-6 diethyl (1-acetoxy)(4-methylphenyl)methylphosphonate 
• 222850-34-2 diethyl α-bromo-4-methylbenzylphosphonate 
• 79158-25-1 α-fluoro-4-methylbenzylphosphonic acid 
• 79158-15-9 C₁₄H₂₆FO₃PSi₂ 
• 79158-26-2 α-fluoro-4-methylbenzylphosphonic acid bis cyclohexylammonium salt 
• 1104635-63-3 diethyl α-(p-chlorophenylaminothiocarbonyloxy)-α-(p-methylphenyl)methyl phosphonate 
• 1104635-57-5 diethyl α-(p-bromophenylaminothiocarbonyloxy)-α-(p-methylphenyl)methyl phosphonate 
• 174678-80-9 diethyl [(4-α-bromomethyl)phenyldifluoromethyl]-phosphonate 
• 1408232-37-0 C₂₀H₂₂F₂N₃O₃P 
• 1408232-42-7 C₁₆H₁₄F₂N₃O₃P 
• 1408232-39-2 C₂₄H₂₄F₂N₃O₃P 

Relevant academic research and scientific papers

A convenient and mild protocol for preparation of α – trimethylsilyloxyphosphonates using sulfamic acid and their oxidation to α – ketophosphonates in the presence of N-bromosuccinimide

A convenient and mild protocol was developed for the trimethylsilylation of α-hydroxyphosphonates using hexamethyldisilazane as the silylating agent in the presence of sulfamic acid (SA) as a heterogeneous solid acid catalyst in dichloromethane as the rea

Method for synthesizing aromatic ring-containing alpha-hydroxyphosphonate through copper catalysis

The invention relates to a method for synthesizing aromatic ring-containing alpha-hydroxyphosphonate through copper catalysis. The method comprises the following steps: dissolving diethyl phosphite and aromatic aldehyde in an organic solvent, adding a cop

Rational synthesis of α-hydroxyphosphonic derivatives including dronic acids

New, green methods have been elaborated for the syntheses of α-hydroxyphosphonates and α-hydroxymethylenebisphosphonic derivatives (HMBPs, dronates). α-Hydroxyphosphonates were prepared via the Pudovik reaction, while the synthesis of HMBPs has been performed in the three-component reaction of carboxylic acids, phosphorus trichloride and phosphorus acid.

CeCl3?7H2O-catalysed hydrophosphonylation of aldehydes and ketones: An expeditious route to α-hydroxyphosphonates under solvent-free conditions

A cerium(III) chloride-catalysed expeditious synthesis of α-hydroxyphosphonates via a modified Abramov synthetic protocol has been developed. The scope of the current protocol is broad, with a range of aromatic, α,β-unsaturated and heterocyclic aldehydes

Highly efficient green synthesis of α-hydroxyphosphonates using a recyclable choline hydroxide catalyst

Choline hydroxide has been found to be an efficient basic ionic liquid catalyst for the synthesis of α-hydroxyphosphonates. Hydrophosphonylation of aldehydes was performed via the nucleophilic addition of diethylphosphite to aldehydic carbonyl compounds, in the presence of choline hydroxide under neat as well as solvent conditions. A wide array of substrates, including aromatic, fused aromatic, and heterocyclic aldehydes, were efficiently converted to their corresponding products in good yields. This protocol provides an alternative method for the straightforward synthesis of α-hydroxyphosphonates in high yields.

Bi(NO3)3.5H2O catalyzed phosphonylation of aldehydes: An efficient route to α-hydroxyphosphonates

The Bi(NO3)3.5H2O mediated synthesis of α-hydroxyphosphonates via phosphonylation of aldehydes is reported herein. Both conventional and microwave technology was efficiently applied to range of aromatic, heteroaromatic, α,

Cholic acid-alpha-amino phosphonate derivative and synthesis method thereof

The invention belongs to the field of medicine chemistry and particularly relates to a cholic acid-alpha-amino phosphonate derivative and a preparation method thereof.Cholic acid and phosphate ester serve as raw materials, and the cholic acid-alpha-amino

Bile acid-alpha-hydroxyphosphonate derivatives and synthetic method thereof

The invention belongs to the field of pharmaceutical chemistry and particularly relates to novel bile acid-alpha-hydroxyphosphonate compounds and a preparation method thereof. Bile acid and phosphate ester are taken as raw materials, the bile acid-alpha-h

Syntheses of bimetallic rare-earth bis(cyclopentadienyl) derivatives supported by bridged bis(guanidinate) ligands and their catalytic property for the hydrophosphonylation of aldehydes

Some bimetallic rare earth bis(cyclopentadienyl) derivatives supported by bridged bis(guanidinate) ligands {(C5H5)2RE[(RN)2CN(CH2)2]}2 [R = iPr, RE = Yb(1), Er(2), Y(3

Synthesis and characterization of ytterbium guanidinates stabilized by bridged bis(phenolate) ligand and their application for the hydrophosphonylation reaction of aldehydes

A series of ytterbium guanidinato complexes stabilized by an amine-bridged bis(phenolate) ligand were prepared, and their catalytic property for the hydrophosphonylation reaction of aldehydes was explored. Metathesis reactions of amine-bridged bis(phenola