104594-82-3

Upstream product

• 102862-22-6 3-p-Tolyl-imidazo[1,2-a]pyridin-2-ol 
• 110520-35-9 N'-(2-Bromo-2-phenyl-acetyl)-hydrazinecarboxylic acid methyl ester 
• 16110-98-8 (Z)-2-phenylbut-2-enedioic acid 
• 106-49-0 p-toluidine 
• 622-47-9 4-tolylacetic acid 
• 611-73-4 Benzoylformic acid 
• 122-00-9 para-methylacetophenone 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 536-74-3 phenylacetylene 
• 110520-32-6 N'-(2-Bromo-2-p-tolyl-acetyl)-hydrazinecarboxylic acid methyl ester 
• 63468-90-6 phenylglyoxylic acid potassium salt 
• 275371-03-4 2-bromo-N-methoxy-2-p-tolyl-acetamide 
• 275371-07-8 2-bromo-N-methoxy-2-phenyl-acetamide 

Downstream Products

• 73442-29-2 2,5-Diphenyl-4-(p-tolyl)-4-cyclopenten-1,3-dion 
• 73442-34-9 4-Phenyl-2,5-di(p-tolyl)-4-cyclopenten-1,3-dion 

Relevant academic research and scientific papers

Solid-Phase Conversion of Four Stereoisomers into a Single Enantiomer

Viedma ripening is an emerging method for the solid-phase deracemization of mixtures of enantiomers. Up to now, the scope of the method has remained limited to molecules with a single stereocenter. We show here that this method can be extended to obtain a single enantiomer from a mixture of stereoisomers with two different stereocenters. In addition, we show that by using tailor-made chiral additives, the conversion time can be reduced by a factor of 100.

Facile Synthesis of γ-Butenolides and Maleic Anhydrides via Annulation of α-Keto Acids and Triazenyl Alkynes

A facile synthesis of γ-butenolides and maleic anhydrides via annulation of α-keto acids and triazenyl alkynes is described. In this process, α-keto acids and triazenyl alkynes could undergo a self-catalyzed annulation at room temperature to deliver γ-butenolides efficiently, while the further addition of BF3-Et2O furnished maleic anhydrides. Overall, these processes have mild reaction conditions, broad scope, and high efficiency.

Synthesis in a stage of N-methoxyindolinones, N-methoxymaleimides and maleic anhydrides starting from α-halogen hydroxamic acids

α-Halo hydroxamic acids were used in the synthesis of N-methoxyindolinones, symmetric and dissymmetric N-methoxymaleimides in good yields. The hydrolysis of N-methoxymaleimides constitues a new and good route to maleic anhydrides.

Synthesis of 3,4-diarylsubstituted maleic anhydride/maleimide via unusual oxidative cyclization of phenacyl ester/amide

A simple and general method has been developed for the synthesis of 3,4-diarylsubstituted maleic anhydride and maleimide through tandem cyclization and oxidation reaction of phenacyl ester or amide. A wide variety of phenacyl esters or amides was treated with DBU under oxygen atmosphere to give the expected compounds in good to excellent yield. Mechanism of the reaction and application of the methodology have been discussed.

SYNTHESE DE N-AMINO MALEIMIDES ET D'ANHYDRIDES MALEIQUES DISUBSTITUES A PARTIR D'α-HALOGENO HYDRAZIDES. ETUDE DU MECANISME DE LA REACTION.

α-Halohydrazides react with 2-aminopyridine to give symmetrically substituted N-aminomaleimides.We have shown that this reaction proceeds through the formation of 4-hydroxyimidazopyridines.This result opens a new route to dissymetrically substituted N-aminomaleimides.The hydrolysis of N-aminomaleimides is a grood route to substituted maleic anhydrides.