1046045-59-3Relevant academic research and scientific papers
SYNTHESIS OF FATOSTATIN BASED POLYCYCLIC COMPOUNDS
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, (2016/06/01)
The present invention relates to methods and strategies for large-scale synthesis of compounds having the chemical structure: (I). The R substituents are H, methyl, isopropyl, benzyl, cyclohexyl, cyclopropylmethyl, methoxy, tert-butyloxycarbonyl, methanes
Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins
Kamisuki, Shinji,Shirakawa, Takashi,Kugimiya, Akira,Abu-Elheiga, Lutfi,Park Choo, Hea-Young,Yamada, Kohei,Shimogawa, Hiroki,Wakil, Salih J.,Uesugi, Motonari
experimental part, p. 4923 - 4927 (2011/09/19)
Fatostatin, a recently discovered small molecule that inhibits activation of sterol regulatory element-binding protein (SREBP), blocks biosynthesis and accumulation of fat in obese mice. We synthesized and evaluated a series of fatostatin derivatives. Our
