1046148-25-7Relevant academic research and scientific papers
2-(Dichloromethylene)azetidines: Stable strained cyclic enamines
Mangelinckx, Sven,Boeykens, Marc,De Kimpe, Norbert
scheme or table, p. 1394 - 1398 (2009/04/06)
2-(Dichloromethylene)azetidines constitute a new class of stable exocyclic enamines. The synthesis of these inductively stabilized N-alkyl-2- methyleneazetidines entails the imination of β-halo ketones, followed by α′,α′-dichlorination and subsequent 1,4- dehydrohalogenation. The synthesis of these azetidines is easy and can be performed on multigram scale in good yield. 2-(Dichloromethylene)azetidines undergo smooth reactions towards electrophilic reagents as evidenced by the ready alkoxyhalogenation and hydrolysis to pyrrolidin-3-ones. Georg Thieme Verlag Stuttgart.
