104615-06-7Relevant academic research and scientific papers
Synthesis and Benzodiazepine Binding Activity of a Series of Novel Triazoloquinazolin-5(6H)-ones
Francis, John E.,Cash, William D.,Barbaz, Beverly S.,Bernard, Patrick S.,Lovell, Richard A.,et al.
, p. 281 - 290 (1991)
Investigation of tricyclic heterocycles related to the 2-arylpyrazoloquinolin-3(5H)-ones, structures with high affinity for the benzodiazepine (BZ) receptor, led to the synthesis of 2-phenyl-triazoloquinazolin-5(6H)-one, a compound wi
Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses
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, (2008/06/13)
[1,2,4]triazolo[1,5-c]quinazoline compounds of the formula STR1 wherein R1 is optionally substituted phenyl, pyridyl, furyl thienyl, dihydro or tetrahydro furanyl or thienyl, pyranyl, or 0-ribofuranosyl; R2 is hydrogen or lower alkyl; X is oxygen or NR3, R3 is as defined in the claims, and ring A is unsubstituted or substituted as set forth in the claims. The compounds wherein X is N--R3 are especially useful as adenosine antagonists and for the treatment of asthma. The compounds wherein X is oxygen are useful as benzodiazepine antagonists and as intermediates in the synthesis of the compounds wherein X is N--R3.
