1046160-73-9Relevant academic research and scientific papers
Total synthesis, revised structure, and biological evaluation of biyouyanagin A and analogues thereof
Nicolaou,Wu, T. Robert,Sarlah, David,Shaw, David M.,Rowcliffe, Eric,Burton, Dennis R.
supporting information; experimental part, p. 11114 - 11121 (2009/02/05)
Isolated from Hypericum species H. Chinese L. var. salicifolium, biyouyanagin A was assigned structure 1a or 1b on the basis of NMR spectroscopic analysis. This novel natural product exhibited significant anti-HIV properties and inhibition of lipopolysacc
Total synthesis and revised structure of biyouyanagin A
Nicolaou,Sarlah, David,Shaw, David M.
, p. 4708 - 4711 (2008/02/10)
(Chemical Equation Presented) It all adds up: A 12-step total synthesis of biyouyanagin A, an inhibitor of HIV replication, has revealed its structure, rendered it available for biological investigations, and allows the synthesis of analogues. The convergent synthesis involves two cascade sequences and a remarkably selective [2+2] cycloaddition reaction to forge the cyclobutane ring of the target molecule in the ultimate step.
