1046321-35-0

Basic information

• Product Name: 2-(2-bromoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide
• Synonyms: 2-(2-bromoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide
• CAS NO: 1046321-35-0
• Molecular Weight: 434.073
• Mol File: 1046321-35-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-bromoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-bromoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide(1046321-35-0)
• EPA Substance Registry System: 2-(2-bromoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide(1046321-35-0)

Safety Data

• Hazardous Substances Data: 1046321-35-0(Hazardous Substances Data)

Upstream product

• 50-65-7 Niclosamide 
• 540-51-2 2-bromoethanol 

Downstream Products

• 1420290-84-1 5-chloro-N-(2-chloro-4-nitrophenyl)-2-(2-piperidin-1-yl-ethoxy)benzamide 
• 1420290-85-2 5-chloro-N-(2-chloro-4-nitrophenyl)-2-[2-(4-methylpiperazin-1-yl)-ethoxy]benzamide 

Relevant articles and documents

Discovery of O-alkylamino-tethered niclosamide derivatives as potent and orally bioavailable anticancer agents

Niclosamide has been identified to potently inhibit the activation, nuclear translocation, and transactivation of STAT3. Nevertheless, the poor aqueous solubility and bioavailability of niclosamide have hindered its further clinical development for cancer therapy. To discover new molecules with enhanced druglike properties, a series of novel O-alkylamino-tethered derivatives of niclosamide have been designed, synthesized, and biologically evaluated. Among them, compound 11 (HJC0152) has been demonstrated to significantly suppress MDA-MB-231 xenograft tumor growth in vivo (ip and po), indicating its great potential as efficacious and orally bioavailable therapeutics for human cancer.