1046357-31-6Relevant academic research and scientific papers
NITRIC OXIDE RELEASING STEROIDS
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Page/Page column 133-134, (2008/12/08)
The invention relates to nitrooxyderivative of corticosteroids of generalformula (I) and pharmaceutically acceptable salts or stereoisomers thereof wherein R is the corticosteroid residue of formula (II): wherein: R1 is OH, R2-CH3, or R1 and R2 are taken together to form a group of formula (III) R3 is C1 or F; R4 is H or F; wherein R1, R2, R3 and R4 can be linked to the correspondent carbon atoms of the steroidal structure in position β or β; with the proviso that: when R1 and R2 are the group of formula (III) then R3 is F and R4 is H or F; The compounds are useful in the treatment of respiratory diseases, inflammatory diseases, dermatological diseases and oculardiseases.
