1046488-98-5

Basic information

• Product Name: C₂₇H₃₂N₂O₂
• CAS NO: 1046488-98-5
• Molecular Weight: 416.563
• Mol File: 1046488-98-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₃₂N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₃₂N₂O₂(1046488-98-5)
• EPA Substance Registry System: C₂₇H₃₂N₂O₂(1046488-98-5)

Safety Data

• Hazardous Substances Data: 1046488-98-5(Hazardous Substances Data)

Upstream product

• 5344-90-1 2-Aminobenzyl alcohol 
• 1028331-11-4 5-chloro-2-(2,6-diethylphenyl)-4-methoxy-5,6,7,8-tetrahydroquinoline 

Relevant articles and documents

Design and optimization of aniline-substituted tetrahydroquinoline C5a receptor antagonists

A series of aniline-substituted tetrahydroquinoline C5a receptor antagonists were discovered. A functionality requirement of ortho substitution on the aniline was revealed. Secondary anilines, in general, outperformed tertiary analogs in inhibition of C5a-induced calcium mobilization. Further enhancement of activity was realized in the presence of an ortho hydroxyalkyl side chain. The functional IC50 of selected analogs was optimized to the single-digit nanomolar level.