1046493-35-9

Basic information

• Product Name: N-[(1R,2R)-2-(diMethylaMino)cyclohexyl]-N'-[(1S,2R)-2-hydroxy-1,2-diphenylethyl]-Thiourea
• Synonyms: N-[(1R,2R)-2-(diMethylaMino)cyclohexyl]-N'-[(1S,2R)-2-hydroxy-1,2-diphenylethyl]-Thiourea;N-[(1R,2R)-2-(Dimethylamino)cyclohexyl]-N'-[(1S,2R)-2-hydroxy-1,2-diphenylethyl]thiourea,99%e.e.
• CAS NO: 1046493-35-9
• Molecular Formula: C₂₃H₃₁N₃OS
• Molecular Weight: 397.57674
• Mol File: 1046493-35-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 65-67 °C
• Boiling Point: 541.5±60.0 °C(Predicted)
• Appearance: /
• Density: 1.17±0.1 g/cm3(Predicted)
• PKA: 13.11±0.70(Predicted)
• CAS DataBase Reference: N-[(1R,2R)-2-(diMethylaMino)cyclohexyl]-N'-[(1S,2R)-2-hydroxy-1,2-diphenylethyl]-Thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(1R,2R)-2-(diMethylaMino)cyclohexyl]-N'-[(1S,2R)-2-hydroxy-1,2-diphenylethyl]-Thiourea(1046493-35-9)
• EPA Substance Registry System: N-[(1R,2R)-2-(diMethylaMino)cyclohexyl]-N'-[(1S,2R)-2-hydroxy-1,2-diphenylethyl]-Thiourea(1046493-35-9)

Safety Data

• Hazardous Substances Data: 1046493-35-9(Hazardous Substances Data)

Upstream product

• 1020665-66-0 (1R,2R)-2-isothiocyanato-N,N-dimethylcyclohexanamine 
• 23190-16-1 (1R,2S)-2-Amino-1,2-diphenylethanol 

Relevant articles and documents

Fine-tunable organocatalysts bearing multiple hydrogen-bonding donors for construction of adjacent quaternary and tertiary stereocenters via a michael reaction

The fine-tunable bifunctional amine/thiourea organocatalysts, relying on multipe hydrogen-bonding donors was investigated. A representative set of aryl and alkyl substituted nitroolefins were surveyed under the optimal experimental conditions. The trisubstituted carbon nucleophiles were examined with a 10 mol% of catalyst. The significant role of the multiple hydrogen-bonding donors played in the system was demonstrated through the control experiments using less bulky methylated (1R,2R,1'R,2'R)-II-E, (1R,2R,S)-II-F, and (1R,2R,R)-II-G as the catalyst under the optimized reaction condition. The fine tunable amine/thiourea organocatalysts, relying on multiple hydrogen-binding donors, showed excellent activity, diastereoselectivity, enantioselectivity, and structural scope in asymmetric Michael addition of α-substituted β-ketoesters to nitroolefins.