10465-82-4

Basic information

• Product Name: AZODICARBOXYLIC BISMORPHOLIDE
• Synonyms: AZODICARBOXYLIC BISMORPHOLIDE;AZODICARBOXYLIC DIMORPHOLIDE;4,4'-Azodicarbonylbis(morpholine);Diazene-1,2-diylbis(morpholinomethanone);NSC 356022;Azodicarboxylic dimorpholide >=98.0% (N)
• CAS NO: 10465-82-4
• Molecular Formula: C₁₀H₁₆N₄O₄
• Molecular Weight: 256.26
• EINECS: 418-690-0
• Mol File: 10465-82-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 141-143 °C
• Boiling Point: 397.6°Cat760mmHg
• Flash Point: 194.3°C
• Appearance: /
• Density: 1.46g/cm³
• Vapor Pressure: 1.56E-06mmHg at 25°C
• Refractive Index: 1.626
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.97±0.20(Predicted)
• BRN: 1013753
• CAS DataBase Reference: AZODICARBOXYLIC BISMORPHOLIDE(CAS DataBase Reference)
• NIST Chemistry Reference: AZODICARBOXYLIC BISMORPHOLIDE(10465-82-4)
• EPA Substance Registry System: AZODICARBOXYLIC BISMORPHOLIDE(10465-82-4)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 10465-82-4(Hazardous Substances Data)

Usage

Uses

Azodicarboxylic dimorpholide has been used in the galanthamine ring system reaction that utilizes an intramolecular Heck reaction to establish the benzofuran ring system. Galanthamine exhibits potent acetylcholinesterase inhibitory activity and is important in the management of Alzheimer′s disease.

General Description

Azodicarboxylic dimorpholide is a yellow to dark yellow powder or crystals

InChI:InChI=1/C10H16N4O4/c15-9(13-1-5-17-6-2-13)11-12-10(16)14-3-7-18-8-4-14/h1-8H2/b12-11+

Upstream product

• 110-91-8 morpholine 
• 4143-61-7 diethyl diazodicarboxylate 
• 1972-28-7 diethylazodicarboxylate 

Downstream Products

• 1226859-18-2 C₃₃H₃₅N₇O₇S 
• 1226859-24-0 C₃₇H₄₂N₆O₁₂S 
• 1226859-23-9 C₃₇H₄₁N₇O₁₄S 
• 52962-89-7 N-cyclohexanesulfonyl-N,N'-bis-(morpholine-4-carbonyl)-hydrazine 
• 35003-64-6 4,4'-(2-dianilinophosphoryl-2,3-diaza-butanedioyl)-bis-morpholine 
• 52962-88-6 N-(4-chloro-benzenesulfonyl)-N,N'-bis-(morpholine-4-carbonyl)-hydrazine 
• 52962-87-5 N,N'-bis-(morpholine-4-carbonyl)-N-(toluene-4-sulfonyl)-hydrazine 
• 52962-86-4 N-benzenesulfonyl-N,N'-bis-(morpholine-4-carbonyl)-hydrazine 

Relevant articles and documents

Synthesis of five libraries of 6,5-fused heterocycles to establish the importance of the heterocyclic core for antiplasmodial activity

Research has indicated that N-myristoyl transferase, an enzyme that catalyzes the addition of a myristate group to the N-terminal glycine residues of proteins, is involved in the myristoylation of more than 100 proteins. Genetic knockdown of the enzyme proved detrimental for the viability of the parasite P. knowlesi. A crystal structure of P. vivax N-myristoyl transferase (pvNMT), containing a 3-methyl benzofuran ligand has made it possible to assess key amino acid residue-ligand interactions. We synthesized five libraries of 6,5-fused heterocycles to establish the importance of the heterocycles as core scaffolds, as well as introduced various aromatic amides and esters to determine which carbonylic group affects the potency of each heterocyclic antiplasmodial agent.

Thiohydrazine-1,2-dicarboxylic acid derivatives and process for their preparation

The invention concerns new 1-tert.-alkyl-thiohydrazine-1,2-dicarboxylic a derivatives, their production, and their use as reagents for the transfer of a 1-tert.-alkylthio residue, particularly of a 1-tert.-butylthio residue as a protective group for thiols.

Addition of phosphorous acid diamides and their phenylogs to double-bound systems

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