104654-24-2

Upstream product

• 63049-56-9 3-Chloro-1-phenyl-3-buten-1-ol 
• 18303-04-3 N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide 
• 294862-14-9 2-methylene-4-phenyl-1-(toluene-4-sulfonyl)-azetidine 
• 5661-55-2 4-phenylazetidin-2-one 
• 98-59-9 p-toluenesulfonyl chloride 
• 916756-35-9 N-(3-chloro-1-phenyl-but-3-enyl)-4-methyl-benzenesulfonamide 

Downstream Products

• 1258509-98-6 1-benzyl 4-ethyl 2-(3-(4-methylphenylsulfonamido)-3-phenylpropanoyl)-2-((triethylsilyl)oxy)succinate 
• 294862-14-9 2-methylene-4-phenyl-1-(toluene-4-sulfonyl)-azetidine 

Relevant academic research and scientific papers

β-lactams as formal dipoles through amide-bond activation

Activation of β-lactams can be achieved by simple Lewis-base catalysis to trigger an unprecedented reaction based on the formal dipolar behaviour of a strained amide bond. A new synthetic route for 1,3-oxazinan-6-ones is presented by reaction of β-lactams

General and highly efficient synthesis of 2-alkylideneazetidines and β-lactams via copper-catalyzed intramolecular N-vinylation

N-Tosyl-3-halo-3-butenylamines underwent efficient Ullmann-type coupling with the catalysis of Cul/N,N-dimethylethylenediamine to afford 2-alkylideneazetidines, which could be readily converted to the corresponding β-lactams by oxidation with O3/sub