104667-75-6

Upstream product

• 2582-30-1 aminoguanidine bicarbonate 
• 2651-15-2 N-[bis(methylthio)methylene]-p-toluenesulfonamide 
• 104667-67-6 methyl N'-cyano-N-[(4-methylphenyl)sulfonyl]imidothiocarbamate 
• 70-55-3 toluene-4-sulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 86147-15-1 1-acetyl-3,5-diamino-1H-1,2,4-triazole 
• 1296272-30-4 N-(5-{[(4-methylphenyl)sulfonyl]amino}-1H-1,2,4-triazol-3-yl)acetamide 
• 1296272-29-1 N-(5-amino-1-acetyl-1H-1,2,4-triazol-3-yl)-4-methylbenzenesulfonamide 
• 104667-67-6 C₁₀H₁₁N₃O₂S₂ 

Relevant academic research and scientific papers

Regioselective single-reactor synthesis of arylsulfonyl derivatives of 3,5-diamino-1,2,4-triazole

Arylsulfonylation of 1-acetyl-3,5-diamino-1,2,4-triazole with arylsulfonyl chlorides in pyridine, with the subsequent hydrolysis of the acetyl group, was studied; a new regioselective method for synthesis of N-(5-amino-1H-1,2,4- triazol-3-yl)arylsulfonami

A novel and efficient regiospecific preparation of arenesulfonamide derivatives of 3,5-diamino-1,2,4-triazole

A new simple and efficient procedure was designed for the regiospecific preparation of arenesulfonamide derivatives of 3,5-diamino-1,2,4-triazole 1 which are precursors of N-([1,2,4] triazolo [1,5-a]pyrimidin-2-yl)arenesulfonamides 2, an important family of herbicidal and antibacterial agents. The key feature of this procedure is the preparation of a wide range of compounds 1 on a large scale, in pure form and high yield without the need for any workup or the use of the highly hazardous hydrazine. This was made possible by a novel tandem reaction promoted by sulfuryl chloride to effect the formation of the triazole ring.

Regiospecific synthesis of N-sulfonyl derivatives of 3,5-diamino-1H-1,2,4-triazole and 2,5-diamino-1,3,4-thiadiazole

Condensation of the S,S-dimethyl N-(alkylsulfonyl)carbondithioimidates 1 with aminoguanidine bicarbonate and hydrazinecarbothioamide leads to the regiospecific synthesis of N-sulfonyl derivatives of 3,5-diamino-1H-1,2,4-triazole 2 and 2,5-diamino-1,3,4-thiadiazole 3, respectively.