104681-54-1Relevant articles and documents
ANTIFUNGAL AGENTS
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Page/Page column 37, (2010/02/14)
Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents, wherein: R1, R2 and R3 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.
A new route to 1,1-difluoroolefins from carboxylic acids
Kim, Kyung-Il,McCarthy, James R.
, p. 3223 - 3226 (2007/10/03)
Methodology is described for the conversions of carboxylic acids to 1,1-difluoroolefins via α,α-difluorothioethers (3).
Substituted 1,3,4-Thiadiazoles with Anticonvulsant Activity. 2. Aminoalkyl Derivatives
Stillings, Michael R.,Welbourn, Anthony P.,Walter, Donald S.
, p. 2280 - 2284 (2007/10/02)
This paper describes the synthesis and pharmacological evaluation of a number of substituted 1,3,4-thiadiazoles.The first member of the series, 2-(aminomethyl)-5-(2-biphenylyl)-1,3,4-thiadiazole (7) was found to possess potent anticonvulsant properties in rats and mice and compared favorably with the standard anticonvulsant drugs phenytoin, phenobarbital, and carbamazepine in a number of test situations.The potency of compound 7 was maintained on alkylation of the side-chain nitrogen atom; however, aryl substitution or chain lengthening caused a drop in potency.Replacement of the 2-biphenylyl group by phenyl or benzyl also lead to inactive compounds.