10469-27-9

Basic information

• Product Name: 4-hydroxy-2-(2-hydroxyethyl)-2-phenylbutyronitrile
• Synonyms: 4-hydroxy-2-(2-hydroxyethyl)-2-phenylbutyronitrile;2-Phenyl-2-(2-hydroxyethyl)-4-hydroxybutanenitrile;α,α-Bis(2-hydroxyethyl)benzeneacetonitrile;Einecs 233-958-5
• CAS NO: 10469-27-9
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.253
• EINECS: 233-958-5
• Mol File: 10469-27-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 454.2°Cat760mmHg
• Flash Point: 228.5°C
• Appearance: /
• Density: 1.156g/cm³
• Vapor Pressure: 4.85E-09mmHg at 25°C
• Refractive Index: 1.553
• CAS DataBase Reference: 4-hydroxy-2-(2-hydroxyethyl)-2-phenylbutyronitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-2-(2-hydroxyethyl)-2-phenylbutyronitrile(10469-27-9)
• EPA Substance Registry System: 4-hydroxy-2-(2-hydroxyethyl)-2-phenylbutyronitrile(10469-27-9)

Safety Data

• Hazardous Substances Data: 10469-27-9(Hazardous Substances Data)

Usage

General Description

4-hydroxy-2-(2-hydroxyethyl)-2-phenylbutyronitrile is a chemical compound that consists of a benzene ring with a butyronitrile group and two hydroxyl groups. It is commonly used as a fragrance ingredient in cosmetic and personal care products. This chemical has been found to have skin sensitization potential and is known to cause allergic contact dermatitis. It is important to handle this chemical with care and to follow proper safety precautions when working with it to avoid any potential adverse effects on human health.

InChI:InChI=1/C12H15NO2/c13-10-12(6-8-14,7-9-15)11-4-2-1-3-5-11/h1-5,14-15H,6-9H2

Upstream product

• 75-21-8 oxirane 
• 140-29-4 phenylacetonitrile 
• 854629-88-2 4-ethoxymethoxy-2-(2-ethoxymethoxy-ethyl)-2-phenyl-butyronitrile 
• 70179-05-4 2-phenyl-4-vinyloxy-2-(2-vinyloxy-ethyl)-butyronitrile 

Downstream Products

• 100119-73-1 1,5-dichloro-3-cyano-3-phenylpentane 
• 723272-14-8 4-bromo-2-(2-bromo-ethyl)-2-phenyl-butyric acid 
• 96004-85-2 bis-(1-methyl-4-phenyl-[4]piperidylmethyl)-amine 
• 774-52-7 1-methyl-4-phenylpiperidine 
• 56243-25-5 1-benzyl-4-cyano-4-phenylpiperidine 
• 3627-62-1 1-methyl-4-phenyl-piperidine-4-carbonitrile 
• 70179-02-1 N-tert-Butyl-α,α-divinylphenylacetamid 
• 70179-01-0 α,α-Divinylphenylacetamid 
• 70179-00-9 α,α-Divinylphenylessigsaeure 
• 70178-99-3 β,β-Divinyl-β-phenylethanol 
• 70179-03-2 α,α-Divinylphenylacetonitril 

Relevant articles and documents

A 4-substituted piperidine derivatives synthetic method

The invention relates to a synthesis method of 4-substituted piperidine derivatives. The synthesis method comprises the following steps: continuously reacting alpha-single substituted acetonitrile serving as a raw material with two-molecular ethylene oxide in the presence of a base I, thereby synthesizing compounds (2), wherein not one compound (2) is generated, and the compounds (2) are in tautomeric equilibrium with a compound (6); breaking the balance in the presence of a base II to generate an alcoxyl negative ion compound (3); reacting the compound (3) with R2SO2X or (R2SO2)2O to generate sulphonates (4); performing a cyclization reaction on the sulphonates (4) and primary amine to synthesize 4-substituted piperidine derivatives. Compared with a document reported method, the synthesis method has the advantages that the reaction steps are shortened and the synthetic efficiency is improved.