10469-27-9

Usage

Uses

Used in Cosmetic and Personal Care Products:
4-hydroxy-2-(2-hydroxyethyl)-2-phenylbutyronitrile is utilized as a fragrance ingredient in the cosmetic and personal care industry. Its aromatic properties contribute to the scent profiles of various products, enhancing consumer appeal and experience.
However, due to its skin sensitization potential, it is crucial for manufacturers to ensure that the compound is used within safe concentrations and that appropriate warnings and precautions are communicated to consumers to minimize the risk of allergic reactions. This may involve conducting thorough safety assessments and adhering to regulatory guidelines for the use of fragrance ingredients in cosmetic formulations.

InChI:InChI=1/C12H15NO2/c13-10-12(6-8-14,7-9-15)11-4-2-1-3-5-11/h1-5,14-15H,6-9H2

Upstream product

• 70179-05-4 2-phenyl-4-vinyloxy-2-(2-vinyloxy-ethyl)-butyronitrile 
• 75-21-8 oxirane 
• 140-29-4 phenylacetonitrile 
• 854629-88-2 4-ethoxymethoxy-2-(2-ethoxymethoxy-ethyl)-2-phenyl-butyronitrile 

Downstream Products

• 100119-73-1 1,5-dichloro-3-cyano-3-phenylpentane 
• 723272-14-8 4-bromo-2-(2-bromo-ethyl)-2-phenyl-butyric acid 
• 70179-02-1 N-tert-Butyl-α,α-divinylphenylacetamid 
• 70179-01-0 α,α-Divinylphenylacetamid 
• 70179-00-9 α,α-Divinylphenylessigsaeure 
• 70178-99-3 β,β-Divinyl-β-phenylethanol 
• 70179-03-2 α,α-Divinylphenylacetonitril 
• 96004-85-2 bis-(1-methyl-4-phenyl-[4]piperidylmethyl)-amine 
• 774-52-7 1-methyl-4-phenylpiperidine 
• 56243-25-5 1-benzyl-4-cyano-4-phenylpiperidine 
• 3627-62-1 1-methyl-4-phenyl-piperidine-4-carbonitrile 

Relevant academic research and scientific papers

A 4-substituted piperidine derivatives synthetic method

The invention relates to a synthesis method of 4-substituted piperidine derivatives. The synthesis method comprises the following steps: continuously reacting alpha-single substituted acetonitrile serving as a raw material with two-molecular ethylene oxide in the presence of a base I, thereby synthesizing compounds (2), wherein not one compound (2) is generated, and the compounds (2) are in tautomeric equilibrium with a compound (6); breaking the balance in the presence of a base II to generate an alcoxyl negative ion compound (3); reacting the compound (3) with R2SO2X or (R2SO2)2O to generate sulphonates (4); performing a cyclization reaction on the sulphonates (4) and primary amine to synthesize 4-substituted piperidine derivatives. Compared with a document reported method, the synthesis method has the advantages that the reaction steps are shortened and the synthetic efficiency is improved.