3627-62-1

Basic information

• Product Name: 1-methyl-4-phenylpiperidine-4-carbonitrile
• Synonyms: 1-methyl-4-phenylpiperidine-4-carbonitrile;4-CYANO-1-METHYL-4-PHENYLPIPERIDINE;3-Methyl-4-phenyl-4-piperidinenitrile;1-Methyl-4-phenyl-4-piperidinecarbonitrile
• CAS NO: 3627-62-1
• Molecular Formula: C₁₃H₁₆N₂
• Molecular Weight: 200.27954
• EINECS: 222-847-7
• Mol File: 3627-62-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 332.5 °C at 760 mmHg
• Flash Point: 141 °C
• Appearance: /
• Density: 1.07 g/cm³
• Vapor Pressure: 0.000145mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: 1-methyl-4-phenylpiperidine-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-4-phenylpiperidine-4-carbonitrile(3627-62-1)
• EPA Substance Registry System: 1-methyl-4-phenylpiperidine-4-carbonitrile(3627-62-1)

Safety Data

• Hazardous Substances Data: 3627-62-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H16N2/c1-15-9-7-13(11-14,8-10-15)12-5-3-2-4-6-12/h2-6H,7-10H2,1H3

Upstream product

• 55-86-7 mechlorethamine hydrochloride 
• 140-29-4 phenylacetonitrile 
• 50599-78-5 4-dimethylamino-2-phenyl-butyronitrile 
• 40481-13-8 4-phenyl-4-cyanopiperidine 
• 74-88-4 methyl iodide 
• 71258-18-9 1-benzyl-4-phenyl-piperidine-4-carbonitrile; hydrochloride 
• 50-00-0 formaldehyd 
• 854629-88-2 4-ethoxymethoxy-2-(2-ethoxymethoxy-ethyl)-2-phenyl-butyronitrile 
• 70179-05-4 2-phenyl-4-vinyloxy-2-(2-vinyloxy-ethyl)-butyronitrile 
• 10469-27-9 α,α-bis(2-hydroxyethyl)phenylacetonitrile 
• 100119-73-1 1,5-dichloro-3-cyano-3-phenylpentane 
• 74-89-5 methylamine 
• 51-75-2 nitrogen mustard 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 7475-63-0 1-(1-methyl-4-phenylpiperidin-4-yl)propan-1-one 
• 774-52-7 1-methyl-4-phenylpiperidine 
• 1859-37-6 C-(1-methyl-4-phenyl-piperidin-4-yl)-methylamine 
• 96074-20-3 (1-methyl-4-phenyl-[4]piperidylmethyl)-(1-methyl-4-phenyl-[4]piperidylmethylen)-amine 
• 3627-48-3 pethidinic acid 
• 57-42-1 pethidine 
• 109161-93-5 1-methyl-4-phenyl-4-(1⁽²⁾H-tetrazol-5-yl)-piperidine 
• 96004-85-2 bis-(1-methyl-4-phenyl-[4]piperidylmethyl)-amine 
• 100609-26-5 1-methyl-4-phenyl-piperidine-4-carboxylic acid ; hydrochloride 
• 4220-10-4 (1-methyl-4-phenyl-piperidin-4-yl)-methanol 

Relevant articles and documents

Duraglutin artificial antigen and preparation method thereof

The invention provides a duramine artificial antigen and a preparation method thereof. The nitrile group of the 4-phenylpiperidine-4-carbonitrile is ingeniously reduced into the amino group; carboxylgroups capable of being used for crosslinking are introduced, so the characteristic original appearance of a duraglutin main ring is maintained; butanedioic anhydride is introduced, so acetyl functional groups on a duraglutin side chain is maintained on the said chain; the hapten synthesized by the process can maintain the characteristic group original appearance of duraglutin, and the synthesizedcorresponding artificial antigen has good specificity. The preparation process is simple, and the raw material source is not limited; the prepared artificial antigen can be used for animal immunization to obtain a corresponding duraglutin antibody, has strong antibody specificity, can be used in immunoassay, is suitable for research of various duraglutin immunoassay methods, and can be used as akey raw material for production of a duraglutin immunochromatographic kit.

HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF

The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, and the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.

Nitrile analogs of meperidine as high affinity and selective sigma-1 receptor ligands

A series of N-substituted-4-cyano-4-phenylpiperidine analogs were synthesized and evaluated for binding affinity at opioid receptors and showed no affinity. The series similarity to previously reported σ ligands prompted analysis at σ receptors to determine the SAR for affinity at σ receptors. Within the N-substituent series the saturated analogs showed increased affinity at both σ receptors. Optimal chain length in the N-arylalkyl series for σ1 and σ2 receptors proved to be N-propylphenyl; extension to a four carbon chain dramatically decreased affinity at both receptors. Substituents in the 4-position affect only σ1 affinity; no change in affinity at σ2 was shown. The N-isobutyl, N-phenylpropyl, and N-benzyl analogs are worth pursuing due to their good affinity and selectivity at the σ1 receptor, whereas the N-benzyl analog exhibits the greatest selectivity for σ1.