1047-63-8

Usage

Uses

Used in Cosmetics Industry:
2-(4-(1H-Benzo[d]imidazol-2-yl)phenyl)-1H-benzo[d]imidazole is used as an additive in the cosmetics industry, specifically for the formulation of sunscreens. The compound serves as a UVA absorber, providing protection against the harmful effects of ultraviolet A radiation, which can cause skin aging and increase the risk of skin cancer.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(4-(1H-Benzo[d]imidazol-2-yl)phenyl)-1H-benzo[d]imidazole may be utilized as an intermediate in the synthesis of water-soluble organic compounds with potential applications in drug development. These compounds could be used to enhance the solubility, stability, or bioavailability of active pharmaceutical ingredients, ultimately improving the efficacy and safety of medications.
Used in Chemical Synthesis:
2-(4-(1H-Benzo[d]imidazol-2-yl)phenyl)-1H-benzo[d]imidazole can also be employed as a key intermediate in the synthesis of various organic compounds with diverse applications. Its unique structure allows for further functionalization and modification, enabling the development of new materials with specific properties and uses in different industries, such as electronics, materials science, and environmental protection.

InChI:InChI=1/C20H14N4/c1-2-6-16-15(5-1)21-19(22-16)13-9-11-14(12-10-13)20-23-17-7-3-4-8-18(17)24-20/h1-12H,(H,21,22)(H,23,24)

Upstream product

• 623-27-8 terephthalaldehyde, 
• 95-54-5 1,2-diamino-benzene 
• 109702-84-3 N¹,N⁴-bis(2-aminophenyl)terephthalamide 
• 100-21-0 terephthalic acid 
• 13533-12-5 N,N-dihydroxybenzene-1,4-dicarboximidoyl dichloride 
• 589-29-7 p-xylylene glycol 
• 16524-60-0 terephthalaldehyde bis-(2-aminophenylimine) 
• 874-89-5 4-Cyanobenzyl alcohol 
• 619-65-8 4-cyanobenzoic Acid 
• 100-20-9 terephthaloyl chloride 
• 88-74-4 2-nitro-aniline 
• 750-11-8 N,N'-di(o-nitrophenyl)terephthalamide 

Downstream Products

• 109702-85-4 1,4-bis(5-nitrobenzimidazolyl)benzene 

Relevant academic research and scientific papers

H2O2/Fe(NO3)3-promoted synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles

A new, convenient synthesis of 2-substituted benzimidazoles and benzothiazoles is described. Short reaction time, easy and quick isolation of the products, environmentally friendly procedure, excellent chemoselectivity and excellent yields are main advantages of this procedure. Georg Thieme Verlag Stuttgart.

An efficient synthesis of 2-arylbenzimidazoles from o-phenylenediamines and arylaldehydes catalyzed by Fe/CeO2-ZrO2 nano fine particles

75% Fe/CeO2-ZrO2 nano fine particles (0.005 mol%) are reported as a new catalyst for the efficient synthesis of 2-arylbenzimidazoles. A simple and convenient procedure, easy purification and shorter reaction times are the advantageous features of this method. Springer-Verlag 2011.

FeCl3-doped polyaniline nanoparticles as reusable heterogeneous catalyst for the synthesis of 2-substituted benzimidazoles

FeCl3-doped polyaniline nanoparticles efficiently catalyze the synthesis of 2-substituted benzimidazoles by the reaction of aldehydes with o-phenylenediamine. Synthesis and characterization of the catalyst are described, and the obtained results confirms good dispersion of the FeCl3 on the polyaniline. Simple workup, mild reaction conditions, low cost, easy separation, and reusability of the catalyst are some advantages of this method.

Imidazole-Linked Crystalline Two-Dimensional Polymer with Ultrahigh Proton-Conductivity

Proton-exchange membrane fuel cells are promising energy devices for a sustainable future due to green features, high power density, and mild operating conditions. A facile proton-conducting membrane plays a pivotal role to boost the efficiency of fuel cells, and hence focused research in this area is highly desirable. Major issues associated with the successful example of Nafion resulted in the search for alternate proton conducting materials. Even though proton carrier loaded crystalline porous organic frameworks have been used for proton-conduction, the weak host-guest interactions limited their practical use. Herein, we developed a crystalline 2D-polymer composed of benzimidazole units as the integral part, prepared by the condensation of aryl acid and diamine in polyphosphoric acid medium. The imidazole linked-2D-polymer exhibits ultrahigh proton conductivity (3.2 × 10-2 S cm-1) (at 95% relative humidity and 95 °C) in the pristine state, which is highest among the undoped porous organic frameworks so far reported. The present strategy of a crystalline proton-conducting 2D-polymer will lead to the development of new high performing crystalline solid proton conductor.

Highly efficient anion transport mediated by 1,3-bis(benzimidazol-2-yl)benzene derivatives bearing electron-withdrawing substituents

1,3-Bis(benzimidazol-2-yl)benzene exhibits potent anionophoric activity through a process of anion exchange with a minor level of proton/anion symport. Modification of 1,3-bis(benzimidazol-2-yl)benzene with strong electron-withdrawing substituents, such as trifluoromethyl and nitro groups, leads to up to 789-fold increase in the activity. The benzimidazolyl-NH fragments, the relative position and the number of the benzimidazolyl groups on the central phenyl scaffold play an essential role in the transport.

A simple and convenient one-pot synthesis of benzimidazole derivatives using cobalt(II) chloride hexahydrate as catalyst

A simple and efficient method for the convenient synthesis of 2-arylbenzimidazole has been described on reaction with o-phenylenediamine and various aromatic aldehydes using cobalt(II) chloride hexahydrate as a catalyst. The method is cost-effective, high

Facile and efficient aerobic one-pot synthesis of benzimidazoles using Ce(NO3)3·6H2O as promoter

A series of 2-substituted benzimidazoles was synthesized under aerobic conditions, by simply heating 1,2-diaminobenzene and aldehydes in DMF at 80 °C, employing Ce(NO3)3·6H2O as promoter and atmospheric air as an efficient oxidant. The procedure afforded the products from good to excellent yields. Furthermore, this new economic and eco-friendly protocol avoids the use of toxic metal catalysts, as well as additional bases and oxidants.

Synthesis of 2,2′-(p-phenylene)bisbenzazoles compounds from terephthalohydroxamoyl chloride

In this study, synthesis of symmetric compounds of 2,2′-(p-phenylene) bisbenzothiazole, 2,2′-(p-phenylene)bisbenzimidazole and 5,5′-dimethyl-2,2′-(N-phenylene)bisbenzoxazole were benefited from the reaction of terephthalohydroxamoyl chloride with 2-amino-4-methyl phenol, o-aminothio phenol and o-phenylenediamin compounds. The structures of these compounds were confirmed by elemental analysis, mass, 1H-NMR and FT-IR techniques.

1,4-Bis(2-benzimidazolyl)benzene

The title compound, C20H14N4, lies about an inversion centre and the benzimidazole moiety and the phenyl ring are twisted by 30.9(1)°. The benzimidazole moiety is completely planar, with a maximum deviation of 0.009 (2) angstroms. Intermolecular N-H···N hydrogen bonds give rise to a layered structure, with the layers stacked by van der Waals interactions.

Fe3O4@SiO2/collagen: An efficient magnetic nanocatalyst for the synthesis of benzimidazole and benzothiazole derivatives

In this project, Fe3O4@SiO2 was synthesized and combined with collagen for the preparation of Fe3O4@SiO2/collagen. It was characterized by FT-IR, 1H NMR, VSM, XRD, EDX, SEM and T