104722-44-3Relevant academic research and scientific papers
Chemoselective construction of substituted conjugated dienes using an olefin cross-metathesis protocol
Funk, Timothy W.,Efskind, Jon,Grubbs, Robert H.
, p. 187 - 190 (2007/10/03)
(Chemical Equation Presented) Various substituted conjugated dienes have been made by olefin cross-metathesis. Using either electronic or steric "protection," one of the olefins of the conjugated diene was deactivated relative to the other for cross-metathesis. The reactions proceed with very high chemoselectivity and, when steric deactivation is used, very high diastereoselectivity.
A versatile catalyst for heck reactions of aryl chlorides and aryl bromides under mild conditions
Littke,Fu
, p. 6989 - 7000 (2007/10/03)
In the presence of Cy2NMe, Pd/P(t-Bu)3 serves as an exceptionally mild and versatile catalyst for Heck reactions of aryl chlorides and bromides. A sterically and electronically diverse array of aryl bromides, as well as activated aryl chlorides, couple with a range of mono- and disubstituted olefins at room temperature, furnishing the arylated product with high E/Z stereoselection. The corresponding reactions of a broad spectrum of electron-neutral and electron-rich aryl chlorides proceed at elevated temperature, also with high selectivity. In terms of scope and mildness, Pd/P(t-Bu)3/Cy2NMe represents an advance over previously reported catalysts for these Heck coupling processes.
OBTENTION DE DERIVES ARYL BUTADIENIQUES, ORTHO AMINES OU NON, PAR COUPURE CARBONE-AZOTE, EN MILIEU BASIQUE FORT
Uriac, P.,Bonnic, J.,Huet, J.
, p. 5051 - 5060 (2007/10/02)
Eliminative C-N cleavages are observed upon treatment of 2,5-dihydro-1H-1-benzazepines, of their linear analogs 4-phenyl-1-phenylamino-2-butenes and of 2,3-dihydro-1H-1-benzazepines, in the presence of strong bases (BuLi, NaNH2, t-BuOK).Thus, 16-arylbutad
Reactions of ?-Allylic Palladium Intermediates with Amines
Stakem, Francis, G.,Heck, Richard F.
, p. 3584 - 3593 (2007/10/02)
Several dimeric ?-allylic palladium chloride complexes have been prepared by addition of aryl-, hydrido-, and (carbomethoxy)palladium chlorides, prepared in situ, to various conjugated dienes.Stoichiometric reactions of several of these complexes with secondary amines were carried out and the influence of added ligands and changes in the anions in the complexes on the reactions were noted.The stoichiometric reactions were then compared to similar catalytic reactions.The evidence suggests that the products formed in the palladium-catalyzed reactions of aryl iodides and bromides with conjugated dienes and secondary amines to form arylated dienes and allylic amines involve ?-allylic palladium complexes as intermediates.
