104729-36-4

Upstream product

• 116653-47-5 3β-benzoyloxy-5α,8α-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2,3-diyl)-22-phenylsulfonyl-23,24-bisnorchol-6-ene 
• 136463-16-6 C₃₈H₄₄N₂O₆S 
• 104729-35-3 benzyloxy-3β phenylsulfonyl-22 (phenyl-4' urazolo-1',2')-5α,8α bis-nor-23,24-cholene-6 
• 873-55-2 sodium benzenesulfonate 
• 56006-76-9 C₃₂H₃₈N₂O₅ 
• 136463-14-4 C₃₂H₄₀N₂O₅ 
• 104729-42-2 C₃₇H₄₂IN₃O₄ 
• 104729-37-5 benzyloxy-3β (phenyl-4' urazolo-1',2')-5α,8α bis-nor-23,24-cholene-6 ol-22 
• 104729-41-1 C₄₄H₄₉N₃O₇S 
• 28487-73-2 (22E)-5α,8α-(4'-phenyl)urazoloergosta-6,22-dien-3β-yl benzoate 
• 116653-45-3 3β-benzoyloxy-22-hydroxy-5α,8α-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2,3-diyl)-23,24-bisnorchol-6-ene 
• 81126-45-6 3β-benzoyloxy-5α,8α-ergosta-6,22-dieno-<5,8-b>1',2',3',4'-tetrahydrophthalazino-1',4'-dione 
• 116653-46-4 3β-benzoyloxy-5α,8α-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2,3-diyl)-22-tosyloxy-23,24-bisnorchol-6-ene 

Downstream Products

• 128219-60-3 (22ξ,24R)-3β,24,25-trihydroxy-22-phenylsulfonylcholesta-5,7-diene 
• 249564-48-5 (20S)-3β-(tert-butyldimethylsilyloxy)-22-phenylsulfonyl-23,24-dinorchola-5,7-diene 
• 55721-11-4 24(R),25-dihydroxycholecalciferol 
• 63840-62-0 3-acetate of (24R)-24,25-dihydroxyvitamin D₃ 
• 52092-79-2 (24R,6Z)-<25-hydroxy-9,10-secocholesta-5(10),6,8(9)-trien-3β,24-diyl> diacetate 
• 52092-79-2 (24R,6E)-<25-hydroxy-9,10-secocholesta-5(10),6,8(9)-trien-3β,24-diyl> diacetate 
• 249564-50-9 (20S,22ξ,24R)-3β-(tert-butyldimethylsilyloxy)-22-phenylsulfonylcholesta-5,7-diene-24,25-diol 
• 203737-06-8 (5Z,7E)-(3S,24R)-24,25-dihydroxy-9,10-secocholesta-5,7,10(19)-trien-3β-yl β-D-glycopyranuronic acid 
• 203737-04-6 methyl {[(5Z,7E)-(3S,24R)-24-acetoxy-25-hydroxy-9,10-secocholesta-5,7,10(19)-trien-3β-yl]-2,3,4-tri-O-acetyl-β-D-glucopyranosid}uronate 

Relevant academic research and scientific papers

SYNTHESIS OF (24R)-24,25-DIHYDROXYVITAMIN D3

Two versions of the stereoselective synthesis of (24R)-24,25-dihydroxyvitamin D3 were realized.Vitamin D2 and ergosterol were used as starting materials.Methods are proposed for the production of the following key compounds: 6-Methoxy-23,24-bisnor-9,10-seco-3,5-cyclochola-7,10(19)-dien-22-yl phenyl sulfone; 3β-hydroxy-23,24-bisnorchola-5,7-dien-22-yl phenyl sulfone; (2R)-3-methylbutane-1,2,3-triol 1-p-toluenesulfonate.

An improved synthesis of (24R)-24,25-dihydroxyprovitamin D3

(24R)-24,25-Dihydroxyprovitamin D3 was prepared in 33% overall yield by a six-step procedure starting from the Diels-Alder adduct of ergosteryl benzoate and 1,4-dihydrophthalazine-1,4-dione. The yield thus obtained is more than four times as hi