104730-54-3Relevant articles and documents
PREPARATION OF OPTICALLY ACTIVE 1-ACETOXY-2-ARYLOXYPROPIONITRILES AND ITS APPLICATION TO A FACILE SYNTHESIS OF (S)-(-)-PROPRANOLOL
Matsuo, Noritada,Ohno, Nobuo
, p. 5533 - 5534 (1985)
(S)-1-Acetoxy-2-aryloxypropionitriles were synthesized by an asymmetric hydrolysis of the racemates with an enzyme. (S)-Propranolol, a typical β-adrenergic blocker, was synthesized from (S)-1-acetoxy-2-α-naphthyloxypropionitrile in two steps.