Tetrahedron Letters p. 5533 - 5534 (1985)
Update date:2022-08-05
Topics:
Matsuo, Noritada
Ohno, Nobuo
(S)-1-Acetoxy-2-aryloxypropionitriles were synthesized by an asymmetric hydrolysis of the racemates with an enzyme. (S)-Propranolol, a typical β-adrenergic blocker, was synthesized from (S)-1-acetoxy-2-α-naphthyloxypropionitrile in two steps.
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