PREPARATION OF OPTICALLY ACTIVE 1-ACETOXY-2-ARYLOXYPROPIONITRILES AND ITS APPLICATION TO A FACILE SYNTHESIS OF (S)-(-)-PROPRANOLOL

DOI: 10.1016/S0040-4039(01)80880-7

Source and publish data:

Tetrahedron Letters p. 5533 - 5534 (1985)

Update date:2022-08-05

Topics:

Authors:

Matsuo, Noritada

Ohno, Nobuo

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Article abstract of DOI:10.1016/S0040-4039(01)80880-7

(S)-1-Acetoxy-2-aryloxypropionitriles were synthesized by an asymmetric hydrolysis of the racemates with an enzyme. (S)-Propranolol, a typical β-adrenergic blocker, was synthesized from (S)-1-acetoxy-2-α-naphthyloxypropionitrile in two steps.

Full text of DOI:10.1016/S0040-4039(01)80880-7

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