104757-12-2

Upstream product

• 1621253-10-8 9-[(tert-butoxycarbonyl)oxy]-6,7-dimethoxy-3-oxo-1,3-dihydronaphtho[2,3-c]furan-4-yl trifluoromethanesulfonate 
• 113232-81-8 5,6-dimethoxy-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile 
• 1621253-02-8 2-formyl-4,5-dimethoxy-N,N-dimethylbenzamide 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 103477-58-3 2-(2-bromo-4,5-dimethoxyphenyl)-1,3-dioxolane 
• 1621253-09-5 tert-butyl (9-hydroxy-6,7-dimethoxy-1-oxo-1,3-dihydronaphtho[2,3-c]furan-4-yl)carbonate 
• 1621253-12-0 t-butyl 9-(3,4-dimethoxyphenyl)-6,7-dimethoxy-1-oxo-1,3-dihydronaphtho[2,3-c]furan-4-yl carbonate 
• 1402833-96-8 diethyl 1-(3,4-dimethoxyphenyl)-4-hydroxy-6,7-dimethoxynaphthalene-2,3-dicarboxylate 
• 102952-75-0 4-acetoxy-1-(3,4-dimethoxy-phenyl)-6,7-dimethoxy-[2]naphthoic acid ethyl ester 
• 102657-54-5 1-(3,4-dimethoxy-phenyl)-4-hydroxy-6,7-dimethoxy-[2]naphthoic acid ethyl ester 
• 95938-83-3 1-(3,4-dimethoxy-phenyl)-4-hydroxy-6,7-dimethoxy-[2]naphthoic acid 
• 2859-78-1 4-Bromoveratrole 
• 531-88-4 5,6-dimethoxyphthalide 
• 102752-19-2 1-(3,4-dimethoxy-phenyl)-4-hydroxy-3-hydroxymethyl-6,7-dimethoxy-[2]naphthoic acid 

Downstream Products

• 119417-27-5 4-ethoxycarbonyloxy-9-(3,4-dimethoxy-phenyl)-6,7-dimethoxy-3H-naphtho[2,3-c]furan-1-one 
• 122767-03-7 4-acetoxy-9-(3,4-dimethoxy-phenyl)-6,7-dimethoxy-3H-naphtho[2,3-c]furan-1-one 

Relevant academic research and scientific papers

An Optimized and General Synthetic Strategy To Prepare Arylnaphthalene Lactone Natural Products from Cyanophthalides

A simple method for the preparation of arylnaphthalene lactone natural products was developed and used to synthesize diphyllin (10), justicidin A (12), cilinaphthalide B (13), taiwanin E (15), chinensinaphthol (16), taiwanin E methyl ether (17), chinensin

METHOD FOR PREPARATION OF JUSTICIDIN A DERIVATIVES OF ARYLNAPHTHALENE LIGNAN STRUCTURE

The present disclosure relates to a novel method for preparing an arylnaphthalene lignan compound. In synthesis of arylnaphthalene lignan compounds and derivatives according to the present disclosure, a naphthalene backbone may be constructed first and an

Synthesis and bioevaluation of novel arylnaphthalene lignans as anticancer agents

Novel arylnaphthalene lignans were synthesized and their structures were established by 1H NMR, 13C NMR, and HRMS. These compounds were evaluated for their in vitro cytotoxicity against cancer cell lines by MTT assay. Compound 5d possessed the highest cytotoxicity against KB cells. Apoptosis of KB cells treated with 5d was observed by acridine orange and ethidium bromide double staining assay. Western blot analysis disclosed that 5d induced apoptosis via mitochondrial pathway accompanied by an increased expression of Bax and a decreased expression of Bcl-2.

A Novel Synthesis of Naphthalenic Lignan Lactones

Hydroxyphthalans (2) are obtained either through selective reaction of aryllithiums with phthalides (3a,b) or selective reduction of the formyl group in o-formylbenzophenones (7).They are then converted into naphthalenic diesters (5), through isobenzofura