531-88-4

Basic information

• Product Name: Nsc25379
• Synonyms: 1(3H)-Isobenzofuranone, 5,6-dimethoxy-;Macconine;Nsc25379;5,6-diMethoxy-1,3-dihydro-2-benzofuran-1-one
• CAS NO: 531-88-4
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.184
• Product Categories: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 531-88-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 155-157 °C
• Boiling Point: 403 °C at 760 mmHg
• Flash Point: 184.6 °C
• Appearance: /
• Density: 1.26 g/cm³
• Vapor Pressure: 1.05E-06mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: 2-8°C
• Solubility: Chloroform, Ethyl Acetate
• CAS DataBase Reference: Nsc25379(CAS DataBase Reference)
• NIST Chemistry Reference: Nsc25379(531-88-4)
• EPA Substance Registry System: Nsc25379(531-88-4)

Safety Data

• Hazardous Substances Data: 531-88-4(Hazardous Substances Data)

Usage

Uses

m-Meconin is a useful adjunct in the detection of illicit opiate in the management of substance misuses.

InChI:InChI=1/C10H10O4/c1-12-8-3-6-5-14-10(11)7(6)4-9(8)13-2/h3-4H,5H2,1-2H3

Upstream product

• 7664-93-9 sulfuric acid 
• 53295-41-3 3,9,10-trimethoxy-7,11b-dihydro-indeno[2,1-c]chromen-6a-ol 
• 54370-00-2 2-bromo-4,5-dimethoxybenzyl alcohol 
• 67-68-5 dimethyl sulfoxide 
• 50-00-0 formaldehyd 
• 22792-13-8 4-(3’,4’-dimethoxybenzoyl)morpholine 
• 76055-91-9 4-(3,4-dimethoxybenzyl)-6,7-dimethoxyisochroman-3-one 

Downstream Products

• 206130-71-4 3-(α-hydroxy-4-methoxybenzyl)-5,6-dimethoxyphthalide 
• 490-63-1 2-formyl-4,5-dimethoxybenzoic acid 
• 1376449-83-0 3-hydroxy-5,6-dimethoxy-2-phenyl-1H-inden-1-one 
• 1431566-16-3 (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(5,6-dimethoxy-1,3-dioxoisoindolin-2-yl)acetoxy)ethyl)pyridine 1-oxide 
• 17951-19-8 justicidin B 
• 6258-39-5 9-(3,4-Dimethoxyphenyl)-6,7-dimethoxynaphtho<2,3-c>furan-1(3H)-one 
• 145726-16-5 6,7-dimethoxy-9-(4-methoxyphenyl)naphtho[2,3-c]furan-1(3H)-one 
• 1632329-51-1 5,6-Dimethoxy-3-(4-((4-(3-oxo-1,3-dihydroisobenzofuran-1-yl)phenyl)(phenyl)amino)phenyl)isobenzofuran-1(3H)-one 
• 1632329-85-1 3-(4-(diphenylamino)phenyl)-5,6-dimethoxyisobenzofuran-1(3H)-one 

Relevant articles and documents

Synthesis of 3-Unsubstituted Phthalides from Aryl Amides and Paraformaldehyde via Ruthenium(II)-Catalyzed C–H Activation

A straightforward and convenient route has been developed for the synthesis of 3-unsubstituted phthalide derivatives from aryl amides and paraformaldehyde by ruthenium(II)-catalyzed C–H activation. The reaction proceeds through tandem ortho-hydroxymethylation of aryl amide and subsequent intramolecular lactonization.

Fast microwave promoted palladium-catalyzed synthesis of phthalides from bromobenzyl alcohols utilizing DMF and Mo(CO)6 as carbon monoxide sources

A fast method utilizing in situ generated CO for the synthesis of phthalides has been developed. DMF and Mo(CO)6 were applied as two alternative CO-sources in these microwave promoted carbonylation-lactone formation reactions. Mo(CO)6 was found to be the more generally applicable CO-source and provided phthalides as well as dihydroisocoumarin, dihydroisoindone, and phthalimide from the corresponding aryl bromide via an efficient CO insertion within a 1h reaction time.

Electrochemical Oxidation of Aromatic Ethers. Part 9. Proof of the Mode of Aryl-Aryl Coupling in 4-Benzylisochroman-3-ones, and the Oxidative Reactions of 2-and 3-Aralkyl-1,2,3,4-tetrahydroisoquinolines

The influence of the solvent upon the coupling reactions of 4-(3,4-dimethoxybenzyl)-6,7-dimethoxyisochroman-3-one has been studied and it is shown that formation of the product, 7a,8-dihydro-3,10,11-trimethoxy-2H-phenanthrofuran-2,7(5H)-dione, proceeds through a six-membered ring transition state.Anodic oxidation of 2-aralkyl-1,2,3,4-tetrahydroisoquinolines leads to cleavage of the aralkyl substituent, whereas 1,2,3,4-tetrahydro-6,7-dimethoxy-3-(3,4-dimethoxybenzyl)-2-methylisoquinoline cyclises to yield 1,2,3,4-tetrahydro-7,10,11-trimethoxy-3-methyl-2,8a-methanodibenzoazocin-6-one and its 1-hydroxy derivative.