1047641-71-3

Upstream product

• 55107-14-7 Methyl 4,4-dimethyl-3-oxopentanoate 
• 1199-28-6 2-(2,4-dichlorophenoxy)ethylamine 
• 120-83-2 2,4-dichlorophenol 
• 870194-65-3 tert-butyl (2-(2,4-dichlorophenoxy)ethyl)carbamate 

Downstream Products

• 919284-02-9 (4-{5-tert-butyl-4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-isoxazol-3-yl}-3-chloro-phenyl)-acetic acid methyl ester 

Relevant academic research and scientific papers

3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists: Part 1

We report the identification of a novel series of trisubstituted isoxazoles as PPAR activators from a high-throughput screen. A series of structural optimizations led to improved efficacy and excellent functional receptor selectivity for PPARδ. The isoxazoles represent a series of agonists which display a scaffold that lies outside the typical PPAR agonist motif.