1199-28-6

Basic information

• Product Name: 2-(2,4-dichlorophenoxy)ethanamine
• Synonyms: 2-(2,4-dichlorophenoxy)ethanamine
• CAS NO: 1199-28-6
• Molecular Formula: C₈H₉Cl₂NO
• Molecular Weight: 206
• Mol File: 1199-28-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 300.9°Cat760mmHg
• Flash Point: 135.8°C
• Appearance: /
• Density: 1.308g/cm³
• Vapor Pressure: 0.00109mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: 2-(2,4-dichlorophenoxy)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-dichlorophenoxy)ethanamine(1199-28-6)
• EPA Substance Registry System: 2-(2,4-dichlorophenoxy)ethanamine(1199-28-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1199-28-6(Hazardous Substances Data)

Usage

General Description

2-(2,4-dichlorophenoxy)ethanamine, also known as beta-aminomethyl-2,4-dichlorophenyl ether, is a chemical compound with the molecular formula C8H9Cl2NO. It is an amine derivative of 2,4-dichlorophenoxyacetic acid (2,4-D), which is a widely used herbicide. 2-(2,4-dichlorophenoxy)ethanamine is primarily used as an intermediate in the synthesis of various pharmaceuticals and agricultural chemicals. It is a colorless to pale yellow liquid with a faint amine odor, and it is soluble in water. The compound has potential health effects and should be handled and used with caution in industrial and research settings.

InChI:InChI=1/C8H9Cl2NO/c9-6-1-2-8(7(10)5-6)12-4-3-11/h1-2,5H,3-4,11H2

Upstream product

• 138505-73-4 C₁₆H₁₁Cl₂NO₃ 
• 120-83-2 2,4-dichlorophenol 
• 870194-65-3 tert-butyl (2-(2,4-dichlorophenoxy)ethyl)carbamate 
• 6954-77-4 1-(2-bromoethoxy)-2,4-dichlorobenzene 
• 100-97-0 hexamethylenetetramine 

Downstream Products

• 68250-91-9 2-(4-chloro-phenyl)-3-[2-(2,4-dichloro-phenoxy)-ethyl]-thiazolidin-4-one 
• 68250-82-8 2-(2-chloro-phenyl)-3-[2-(2,4-dichloro-phenoxy)-ethyl]-thiazolidin-4-one 
• 68250-74-8 3-[2-(2,4-dichloro-phenoxy)-ethyl]-2-(4-methoxy-phenyl)-thiazolidin-4-one 
• 870194-71-1 N-[2-(2,4-dichlorophenoxy)ethyl]-3-oxo-3-phenylpropionamide 
• 1355026-34-4 C₁₄H₁₃Cl₂N₃O₃ 
• 663623-20-9 tert-Butyl {[2-(2,4-dichlorophenoxy)ethyl]amino}acetate 
• 68251-46-7 3-[2-(2,4-dichloro-phenoxy)-ethyl]-2-(2,4-dichloro-phenyl)-1,1-dioxo-1λ⁶-thiazolidin-4-one 
• 68251-36-5 2-(4-chloro-phenyl)-3-[2-(2,4-dichloro-phenoxy)-ethyl]-1,1-dioxo-1λ⁶-thiazolidin-4-one 
• 68251-26-3 2-(2-chloro-phenyl)-3-[2-(2,4-dichloro-phenoxy)-ethyl]-1,1-dioxo-1λ⁶-thiazolidin-4-one 
• 68251-09-2 3-[2-(2,4-dichloro-phenoxy)-ethyl]-1,1-dioxo-2-phenyl-1λ⁶-thiazolidin-4-one 
• 68251-18-3 3-[2-(2,4-dichloro-phenoxy)-ethyl]-2-(4-methoxy-phenyl)-1,1-dioxo-1λ⁶-thiazolidin-4-one 
• 870194-70-0 (3-chloro-4-{4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid 
• 870194-95-9 (3-chloro-4-{4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester 
• 919284-40-5 (3-chloro-4-{4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-5-furan-2-yl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester 

Relevant articles and documents

Design, synthesis, crystal structure, and herbicidal activity of novel pyrrolidine-2,4-dione derivatives incorporating an alkyl ether pharmacophore with natural tetramic acids as lead compounds

In order to discover green herbicides with novel molecular scaffolds, natural tetramic acids were used as lead compounds to design and synthesize four pyrrolidine-2,4-dione derivatives incorporating a chainlike alkoxyalkyl moiety (4a-4d) and nineteen pyrrolidine-2,4-dione derivatives incorporating a substituted phenoxyethyl moiety (10a-10s)viasubstitution, acylation, cyclization, and acidification reactions. The synthesized target compounds were confirmed by FT-IR,1H NMR,13C NMR and HRMS spectral analyses. The single-crystal structure of compound10awas analyzed by X-ray diffraction, which revealed that the 1-hydroxyethylidene group links the third position of the pyrrolidine heterocycle through a double bond with theZ-configuration. The herbicidal activity was evaluated using barnyard grass (Echinochloa crus-galli) and rape (Brassica campestris) as model plants by a Petri dish culture method. Most target compounds were found to possess moderate to good inhibitory activities against the plant growth at 100 μg mL?1. Among them, the compounds10qand10nshowed the highest herbicidal activities against the roots of barnyard grass and rape seedlings with the corresponding inhibition rates of 65.6% and 84.0%, respectively. This result indicated that pyrrolidine-2,4-dione derivatives incorporating a substituted phenoxyethyl moiety are worthy of further structural optimization.

COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR .