1199-28-6

Usage

Uses

Used in Pharmaceutical Industry:
2-(2,4-dichlorophenoxy)ethanamine is used as an intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a key component in the development of new drugs, contributing to the advancement of medical treatments.
Used in Agricultural Chemical Industry:
In the agricultural sector, 2-(2,4-dichlorophenoxy)ethanamine is utilized as an intermediate for the production of agricultural chemicals. Its role in creating effective and efficient products helps support crop protection and management strategies, ensuring sustainable agricultural practices.
Both applications highlight the versatility of 2-(2,4-dichlorophenoxy)ethanamine as a crucial intermediate in the synthesis of a range of products across different industries, emphasizing its importance in both healthcare and agriculture.

InChI:InChI=1/C8H9Cl2NO/c9-6-1-2-8(7(10)5-6)12-4-3-11/h1-2,5H,3-4,11H2

Upstream product

• 6954-77-4 1-(2-bromoethoxy)-2,4-dichlorobenzene 
• 100-97-0 hexamethylenetetramine 
• 138505-73-4 C₁₆H₁₁Cl₂NO₃ 
• 120-83-2 2,4-dichlorophenol 
• 870194-65-3 tert-butyl (2-(2,4-dichlorophenoxy)ethyl)carbamate 

Downstream Products

• 103263-95-2 dichloro-acetic acid-[2-(2,4-dichloro-phenoxy)-ethylamide] 
• 68250-82-8 2-(2-chloro-phenyl)-3-[2-(2,4-dichloro-phenoxy)-ethyl]-thiazolidin-4-one 
• 68250-64-6 3-[2-(2,4-dichloro-phenoxy)-ethyl]-2-phenyl-thiazolidin-4-one 
• 68251-01-4 3-[2-(2,4-dichloro-phenoxy)-ethyl]-2-(2,4-dichloro-phenyl)-thiazolidin-4-one 
• 1047643-55-9 N-[2-(2,4-dichloro-phenoxy)-ethyl]-3-furan-2-yl-3-oxo-propionamide 
• 1047641-69-9 3-oxo-pentanoic acid [2-(2,4-dichloro-phenoxy)-ethyl]-amide 
• 1047641-71-3 4,4-dimethyl-3-oxo-pentanoic acid [2-(2,4-dichloro-phenoxy)-ethyl]-amide 
• 919283-67-3 (3-chloro-4-{4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-5-methyl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester 
• 870194-71-1 N-[2-(2,4-dichlorophenoxy)ethyl]-3-oxo-3-phenylpropionamide 
• 1047641-60-0 3-cyclopropyl-N-[2-(2,4-dichloro-phenoxy)-ethyl]-3-oxo-propionamide 
• 927178-54-9 (2-chloro-4-{4-[2-(2,4-dichlorophenoxy)ethylcarbamoyl]-5-phenylisoxazol-3-ylmethoxy}phenyl)acetic acid methyl ester 
• 927187-40-4 3-(2-chloro-phenyl)-N-[2-(2,4-dichloro-phenoxy)-ethyl]-3-oxo-propionamide 
• 927187-35-7 N-[2-(2,4-dichloro-phenoxy)-ethyl]-3-oxo-3-o-tolyl-propionamide 
• 663623-20-9 tert-Butyl {[2-(2,4-dichlorophenoxy)ethyl]amino}acetate 

Relevant academic research and scientific papers

Design, synthesis, crystal structure, and herbicidal activity of novel pyrrolidine-2,4-dione derivatives incorporating an alkyl ether pharmacophore with natural tetramic acids as lead compounds

In order to discover green herbicides with novel molecular scaffolds, natural tetramic acids were used as lead compounds to design and synthesize four pyrrolidine-2,4-dione derivatives incorporating a chainlike alkoxyalkyl moiety (4a-4d) and nineteen pyrrolidine-2,4-dione derivatives incorporating a substituted phenoxyethyl moiety (10a-10s)viasubstitution, acylation, cyclization, and acidification reactions. The synthesized target compounds were confirmed by FT-IR,1H NMR,13C NMR and HRMS spectral analyses. The single-crystal structure of compound10awas analyzed by X-ray diffraction, which revealed that the 1-hydroxyethylidene group links the third position of the pyrrolidine heterocycle through a double bond with theZ-configuration. The herbicidal activity was evaluated using barnyard grass (Echinochloa crus-galli) and rape (Brassica campestris) as model plants by a Petri dish culture method. Most target compounds were found to possess moderate to good inhibitory activities against the plant growth at 100 μg mL?1. Among them, the compounds10qand10nshowed the highest herbicidal activities against the roots of barnyard grass and rape seedlings with the corresponding inhibition rates of 65.6% and 84.0%, respectively. This result indicated that pyrrolidine-2,4-dione derivatives incorporating a substituted phenoxyethyl moiety are worthy of further structural optimization.

3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists: Part 1

We report the identification of a novel series of trisubstituted isoxazoles as PPAR activators from a high-throughput screen. A series of structural optimizations led to improved efficacy and excellent functional receptor selectivity for PPARδ. The isoxazoles represent a series of agonists which display a scaffold that lies outside the typical PPAR agonist motif.

COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR .

SUBSTITUTED GLYCINE DERIVATIVES FOR USE AS MEDICAMENTS

The compounds of formula (I) are substituted glycine derivatives useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, arthritis, neuropathological disorders,