1047675-31-9

Upstream product

• 146603-79-4 Methyl 2-(2-phenylethynyl)isonicotinate 
• 584-08-7 potassium carbonate 
• 105-36-2 ethyl bromoacetate 
• 1047675-29-5 methyl 2-(2-phenylethyl)piperidine-4-carboxylate 

Relevant academic research and scientific papers

AZA-BRIDGED-RING COMPOUND

[PROBLEMS] Provided is a compound which has an antagonistic action on a muscarinic M3 receptor and is useful as an active ingredient of a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like. [MEANS FOR SOLVING PROBLEMS] The present inventors have made studies on a compound having an antagonistic action on the binding of a muscarinic M3 receptor, and they have found that an aza-bridged-ring compound or a salt thereof has an antagonistic action on the binding of a muscarinic M3 receptor, thereby completing the present invention. The aza-bridged-ring compound of the present invention has an antagonistic action on the binding of a muscarinic M3 receptor, and can be used as a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like.

SUBSTITUTED 3-AMINOQUINUCLIDINES

Compounds of the formula STR1 wherein W, Ar 1, Ar 2 and Ar. sup.3 are defined as below; and the pharmaceutically acceptable salts of such compounds.These compounds are substance P antagonists and useful in the treatment of gastrointestinal disorders, inflammatory disorders, central nervous system disorders and pain.