104768-01-6Relevant academic research and scientific papers
Clarifying the use of benzylidene protecting group for d-(+)-ribono-1,4-lactone, an essential building block in the synthesis of c-nucleosides
Allevi, Pietro,Casati, Silvana,Ciuffreda, Pierangela,Mingione, Alessandra,Ottria, Roberta,Rota, Paola
, (2021/11/08)
In the last two years, nucleosides analogues, a class of well-established bioactive com-pounds, have been the subject of renewed interest from the scientific community thanks to their antiviral activity. The COVID-19 global pandemic, indeed, spread light
Spectroscopic, crystallographic and computational studies of the formation and isomerization of cyclic acetals and ketals of pentonolactones
Han,Joullie,Fokin,Petasis
, p. 2535 - 2562 (2007/10/02)
The different reactivities of D-ribonolactone, L-arabinonolactone, D-xylonolactone, D-lyxonolactone and 2-deoxy-D-ribonolactone toward benzaldehyde and acetone in acidic media, were examined. The reactions involved complex equilibria and were investigated with extensive 13C NMR studies as well as X-ray crystallographic analysis of selected products. Molecular mechanics (MM2) and semiempirical (PM3 and AM1) calculations of some derivatives were carried out in order to facilitate structural and conformational assignments. The differences in reactivity observed for the reactions of D-pentono-1,4-lactones with benzaldehyde and acetone are rationalized in terms of their structural and conformational features.
2,4-O-benzylidene-D-ribono-1,5-lactone: a revision of structure
Chittenden, Gordon J. F.,Regeling, Henk
, p. 186 - 187 (2007/10/02)
The main product resulting from the reaction of D-ribonolactone with benzaldehyde dimethyl acetal is a 2,3-O-benzylidene derivative of the 1,4-lactone, and not the 2,4-O-benzylidene analogue of the 1,5-lactone, as suggested previously.Chemical and physica
