10477-47-1Relevant articles and documents
NMRP versus "click" chemistry for the synthesis of semiconductor polymers carrying pendant perylene bisimides
Lang, Andreas S.,Neubig, Anne,Sommer, Michael,Thelakkat, Mukundan
, p. 7001 - 7010 (2010)
The synthesis of well-defined polymers with pendant perylene bisimide (PBI) groups by a combination of nitroxide-mediated radical polymerization (NMRP) of trimethylsilyl propargyl acrylate followed by copper-catalyzed azide-alkyne cycloaddition (CuAAC, "click" chemistry) is described. The kinetics of NMRP of trimethylsilyl propargyl acrylate polymerization was monitored by 1H NMR and size exclusion chromatography (SEC). Almost quantitative conversion in the "click" reaction with an azide functionalized PBI derivative was proven by FTIR and 1H NMR analysis. Thus, semiconductor polymers carrying PBI pendant groups with Mn up to 15800 g·mol-1 and polydispersity indices as good as 1.16 were obtained by this route. These polymers were compared with poly(perylene bisimide acrylate)s, PPerAcr(CH2)11, and PPerAcr(CH 2)6, which were synthesized by direct NMRP of PBI acrylates. These samples do not carry any triazol unit and they differ in their spacer length connecting the PBI unit to the main chain. All polymers were comparatively studied by SEC, thermogravimetry, differential scanning calorimetry, polarization microscopy, UV/vis spectroscopy, and photoluminescence measurements. The crystalline structure of the polymers was analyzed by X-ray diffraction. Inductively coupled plasma mass spectrometry analysis confirmed that copper content in the "click" polymer could be reduced down to 126 ppm (w/w).
Construction of an Artificial Glutathione Peroxidase Active Site on Copolymer Vesicles
Yin, Yanzhen,Huang, Xin,Lv, Chunyan,Wang, Liang,Yu, Shuangjiang,Luo, Quan,Xu, Jiayun,Liu, Junqiu
, p. 1505 - 1516 (2010)
To construct an efficient GPx mimic, a novel method for preparing polymer-based vesicles carrying GPx-active sites was developed. A series of block copolymers loaded with recognition and catalytic sites were synthesized based on polystyrene-block-poly[tri(ethylene glycol) methyl ether acrylate]s (PS-PMEO3MAs). By altering the molar ratio of the functional copolymers, vesicles with GPx activity were obtained by self-assembly of these functional copolymers through blending. The optimum GPx mimic constructed by the blending process exhibited high catalytic activity and acted as a real catalyst with typical saturation kinetics behavior. The method may be of benefit for designing other enzyme mimics and may cast a light on constructing other biologically related functional nanoparticles.Self-assembly of functional copolymers through blending is a novel and simple method to construct efficient glutathione peroxidase(GPx) mimics. The optimum blended GPx mimic is obtained by optimizing the structure of the functional block copolymers and altering the ratio of the functional block copolymers. The blended GPx mimic exhibits remarkable catalytic activity and acts as a real catalyst with typical saturation kinetics behavior.
Synthesis and corrosion-protective properties of acetylenic esters of bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
Mamedov
, p. 1316 - 1320 (2004)
A procedure was developed for preparing acetylenic esters of bicyclo[2.2.1]hept-5-ene-2-carboxylic acid. The structures of the compounds were confirmed by IR and 1H NMR spectroscopy. The Kovats indices of the compounds were determined, and their boiling points were estimated by gas-liquid chromatography. The protective properties of the esters against acid corrosion of steel were studied.
Synthesis of polyfunctional triethoxysilanes by 'click silylation'
Singh, Gurjaspreet,Mangat, Satinderpal Singh,Singh, Jandeep,Arora, Aanchal,Sharma, Ramesh K.
, p. 903 - 909 (2014)
The copper-catalyzed 'click silylation' has been exploited for the chemical modification of γ-azidopropyltriethoxysilane (AzPTES) with a wide range of terminal alkynes (1a-1v) in a one-pot operation. The novel 1,2,3-triazole-triethoxysilane derivatives (2a-2v) were synthesized by this procedure and comprehensively characterized by IR spectra, 1H and 13C NMR, and HRMS studies.
De Novo Design of Star-Shaped Glycoligands with Synthetic Polymer Structures toward an Influenza Hemagglutinin Inhibitor
Hoshino, Yu,Matsubara, Teruhiko,Miura, Yoshiko,Nagao, Masanori,Sato, Toshinori,Yamaguchi, Ai
, (2022/01/19)
Synthetic polymers with well-defined structures allow the development of nanomaterials with additional functions beyond biopolymers. Herein, we demonstrate de novo design of star-shaped glycoligands to interact with hemagglutinin (HA) using well-defined synthetic polymers with the aim of developing an effective inhibitor for the influenza virus. Prior to the synthesis, the length of the star polymer chains was predicted using the Gaussian model of synthetic polymers, and the degree of polymerization required to achieve multivalent binding to three carbohydrate recognition domains (CRDs) of HA was estimated. The star polymer with the predicted degree of polymerization was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization, and 6′-sialyllactose was conjugated as the glycoepitope for HA. The designed glycoligand exhibited the strongest interaction with HA as a result of multivalent binding. This finding demonstrated that the biological function of the synthetic polymer could be controlled by precisely defining the polymer structures.
Synthesis of polyfunctional triethoxysilanes by 'click silylation'
Singh, Gurjaspreet,Mangat, Satinderpal Singh,Singh, Jandeep,Arora, Aanchal,Sharma, Ramesh K.
supporting information, p. 903 - 909 (2015/03/03)
The copper-catalyzed 'click silylation' has been exploited for the chemical modification of γ-azidopropyltriethoxysilane (AzPTES) with a wide range of terminal alkynes (1a-1v) in a one-pot operation. The novel 1,2,3-triazole-triethoxysilane derivatives (2a-2v) were synthesized by this procedure and comprehensively characterized by IR spectra, 1H and 13C NMR, and HRMS studies.
