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Usage

Uses

Used in Pharmaceutical Synthesis:
2-amino-4-chloro-N-methylbenzamide(SALTDATA: FREE) is used as a key intermediate in the pharmaceutical industry for the synthesis of various drugs. Its presence in the molecular structure of target compounds allows for the development of new therapeutic agents with specific pharmacological properties.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-amino-4-chloro-N-methylbenzamide(SALTDATA: FREE) is utilized as a building block for the design and synthesis of novel compounds with potential therapeutic applications. Its structural features facilitate the exploration of new chemical space and the optimization of drug candidates for improved efficacy and safety.
Used in Drug Discovery:
2-amino-4-chloro-N-methylbenzamide(SALTDATA: FREE) plays a role in drug discovery processes, where it is employed to screen for biological activity and to identify lead compounds with potential as new drugs. Its unique functional groups and structural attributes make it a valuable component in the development of innovative pharmaceuticals.

InChI:InChI=1/C8H9ClN2O/c1-11-8(12)6-3-2-5(9)4-7(6)10/h2-4H,10H2,1H3,(H,11,12)

Upstream product

• 593-51-1 methylamine hydrochloride 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 1397833-65-6 (2-amino-4-chlorophenyl) (benzotriazole-1-yl)methanone 
• 74-89-5 methylamine 

Downstream Products

• 1612771-93-3 7-chloro-2-(4-chloro-3-nitrophenyl)-3-methyl-2,3-dihydroquinazolin-4(1H)-one 
• 1612771-92-2 7-chloro-3-methyl-2-(4-(trifluoromethoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one 
• 1612771-91-1 7-chloro-2-(2,4-dimethoxyphenyl)-3-methyl-2,3-dihydroquinazolin-4(1H)-one 
• 1612771-90-0 7-chloro-2-(2-chloro-5-nitrophenyl)-3-methyl-2,3-dihydroquinazolin-4(1H)-one 
• 1542270-75-6 7-chloro-2-(2-chloro-6-fluorophenyl)-3-methyl-2,3-dihydroquinazolin-4(1H)-one 
• 1612771-94-4 7-chloro-2-(3-methoxyphenyl)-3-methyl-2,3-dihydroquinazolin-4(1H)-one 
• 1612771-85-3 7-chloro-3-methyl-2-phenyl-2,3-dihydroquinazolin-4(1H)-one 

Relevant academic research and scientific papers

Palladium-Catalyzed Oxidative Three-Component Coupling of Anthranilamides with Isocyanides and Arylboronic Acids: Access to 2,3-Disubstituted Quinazolinones

A novel palladium-catalyzed oxidative three-component coupling of easily accessible N-substituted anthranilamides with isocyanides and arylboronic acids is achieved. This protocol offers an alternative approach toward 2,3-disubstituted quinazolinones with a wide substrate scope and good functional group tolerance.

Synthesis of 2-aryl quinazolinones: Via iron-catalyzed cross-dehydrogenative coupling (CDC) between N-H and C-H bonds

Herein, we describe the direct synthesis of quinazolinones via cross-dehydrogenative coupling between methyl arenes and anthranilamides. The C-H functionalization of the benzylic sp3 carbon is achieved by di-t-butyl peroxide under air, and the subsequent amination-aerobic oxidation process completes the annulation process. Iron catalyzed the whole reaction process and various kinds of functional groups were tolerated under the reaction conditions, providing 31 examples of 2-aryl quinazolinones using methyl arene derivatives in yields of 57-95percent. The synthetic potential has been demonstrated by the additional synthesis of aryl-containing heterocycles. This journal is

Two-directional approach for the rapid synthesis of 2,4-bis-aminoaryl pyridine derivatives

We have developed two different approaches in parallel to rapidly access 2,4-bis aminoaryl pyridine compounds from a common starting material. The C-4/C-2 approach uses palladium-mediated coupling reactions to sequentially functionalize C-4 and then C-2. An alternative C-2/C-4 route uses a regioselective SNAr reaction to first substitute at C-2 then subsequently at C-4 by a palladium-mediated reaction. Both approaches have been used successfully to provide a range of 2,4-bis-aminoaryl pyridine compounds.

A new protocol for the synthesis of primary, secondary and tertiary anthranilamides utilizing N-(2-aminoarylacyl)benzotriazoles

A convenient route for efficient conversion of unprotected anthranilic acids into the corresponding N-(2-aminoarylacyl)benzotrazoles is described. N-(2-Aminoarylacyl)-benzotrazoles have been successfully used to synthesize primary, secondary and tertiary anthranilamides in high yields (71-96%). ARKAT-USA, Inc.

PYRIDINE COMPOUNDS

The present invention relates to compounds that inhibit of focal adhesion kinase function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases such as cancer.