104783-89-3Relevant academic research and scientific papers
Mushroom tyrosinase inhibition activity of some chromones
Piao, Long Zhu,Park, Hyang Rae,Park, Yun Kyung,Lee, Seung Ki,Park, Jeong Hill,Park, Man Ki
, p. 309 - 311 (2007/10/03)
Currently, aloesin is used in the cosmetic industry as a whitening agent because it inhibits tyrosinase activity. Aloesin is a C-glycosylated chromone compound isolated from aloe, and it is difficult to synthesize because of C-glycosyl moiety in the molecule. The purpose of this study is to search for a new chromone compound which is easy to synthesize and which posesses stronger tyrosinase inhibitory activity than aloesin. Fourteen chromone derivatives were synthesized and screened for their mushroom-tyrosinase inhibitory activity. 5-Methyl-7-methoxy-2-(2′-benzyl-3′-oxobutyl)chromone (15) showed the strongest activity among tested compounds. Its activity was not only stronger than aloesin, but also stronger than arbutin and kojic acid. The kinetic analysis revealed a competitive inhibition of 15 with tyrosinase for the L-tyrosine binding site.
SYNTHESIS OF NATURALLY OCCURRING 2,5-DIALKYLCHROMONES. PART 1. SYNTHESIS OF ALOESONE AND ALOESOL
Gramatica, Paola,Gianotti, M. Pia,Speranza, Giovanna,Manitto, Paolo
, p. 743 - 750 (2007/10/02)
A number of 2-alkyl-7-alkoxy ( or hydroxy)-5-methyl-chromones, including naturally occurring aloesone and aloesol, were synthesized starting from ethyl orsellinate via β-keto-sulfoxides as intermediates.
