6110-36-7

Usage

InChI:InChI=1/C11H14O4/c1-4-15-11(13)10-7(2)5-8(14-3)6-9(10)12/h5-6,12H,4H2,1-3H3

Upstream product

• 186581-53-3 diazomethane 
• 2524-37-0 ethyl orselinate 
• 13321-73-8 2-bromo-1,5-dimethoxy-3-methylbenzene 
• 67-56-1 methanol 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 75-03-6 ethyl iodide 
• 74-88-4 methyl iodide 
• 57749-86-7 ethyl 2,4-dimethoxy-6-methylbenzoate 
• 39503-56-5 3-Brom-2-hydroxy-4-methoxy-6-methylbenzoesaeureethylester 
• 64-17-5 ethanol 
• 570-10-5 2-hydroxy-4-methoxy-6-methylbenzoic acid 
• 537-09-7 evernic acid 
• 55018-89-8 2,4-dimethoxy-6-methylbenzoyl chloride 
• 3686-57-5 2,4-dimethoxy-6-methylbenzoic acid 

Downstream Products

• 2524-37-0 ethyl orselinate 
• 57074-24-5 ethyl 3-chloro-6-hydroxy-4-methoxy-2-methylbenzoate 
• 79004-04-9 ethyl 2,3,4-trimethoxy-6-methylbenzoate 
• 104783-89-3 2'-hydroxy-4'-methoxy-6'-methyl-2-(methylsulfinyl)acetophenone 
• 38629-37-7 ethyl 2-hydroxy-3-formyl-4-methoxy-6-methylbenzoate 
• 38629-36-6 5-Formyl-2-hydroxy-4-methoxy-6-methylbenzoesaeureethylester 
• 133363-17-4 1-Benzyloxy-3-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-6-methoxy-8-methoxymethoxy-naphthalene-2-carbaldehyde 
• 133363-16-3 {1-Benzyloxy-3-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-6-methoxy-8-methoxymethoxy-naphthalen-2-yl}-methanol 
• 133363-18-5 1-Benzyloxy-5-bromo-3-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-6-methoxy-8-methoxymethoxy-naphthalene-2-carbaldehyde 
• 120461-92-9 calphostin A 
• 133363-23-2 [(R)-2-(4-Benzyloxy-8-bromo-3,7-dimethoxy-5-methoxymethoxy-naphthalen-2-yl)-1-methyl-ethoxy]-tert-butyl-diphenyl-silane 
• 133363-19-6 [(S)-2-(4-Benzyloxy-8-bromo-3,7-dimethoxy-5-methoxymethoxy-naphthalen-2-yl)-1-methyl-ethoxy]-tert-butyl-diphenyl-silane 
• 133363-21-0 5,5'-Bis-benzyloxy-7,7'-bis-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-2,6,2',6'-tetramethoxy-4,4'-bis-methoxymethoxy-[1,1']binaphthalenyl 
• 133363-21-0 5,5'-Bis-benzyloxy-7,7'-bis-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-2,6,2',6'-tetramethoxy-4,4'-bis-methoxymethoxy-[1,1']binaphthalenyl 

Relevant academic research and scientific papers

Stereoselective synthesis of resorcylic acid lactone Cochliomycin B

The total synthesis of 14-membered resorcylic acid lactone, Cochliomycin B has prescribed, in a convergent manner, from readily available starting materials, D-galactose, L-aspartic acid and ethyl acetoacetate. The key reactions involved in the synthesis are Julia-Kocienski olefination, E-selective Horner-Wadsworth-Emmons olefination and intramolecular lactonization.

Cajanonic acid A analog, composition thereof and application thereof in drugs

The invention discloses a cajanonic acid A analog represented by a formula (I) or (II) shown in the description and stereoisomers, geometric isomers, tautomers, nitrogen oxides, hydrates, solvates, metabolites, esters and pharmaceutically acceptable salts thereof or prodrugs thereof. The invention further discloses a pharmaceutical composition containing the cajanonic acid A analog represented by the formula (I) or (II) or the stereoisomers, hydrates or pharmaceutically acceptable salts thereof. The compound or pharmaceutical composition is mainly used for protecting, treating, curing or relieving type 2 diabetes and complications thereof of patients and is also applied to the aspects of blood fat lowering, weight reducing and the like.

Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin- 5(9bH)-ones as 5-HT2C receptor agonists

A series of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones is described, several examples of which exhibit potent 5-HT2C agonism with excellent selectivity over the closely related 5-HT2A and 5-HT2B receptors. Compounds such as 38 and 44 were shown to be effective in reducing food intake in an acute rat feeding model.

LiCl-Promoted Pd(ii)-catalyzed ortho carbonylation of N,N- dimethylbenzylamines

Palladium-catalyzed highly regioselective carbonylation of substituted N,N-dimethylbenzylamines with the assistance of LiCl was developed. The ortho-functionalized N,N-dimethylbenzylamine was further transformed into ortho-methyl benzoate under mild conditions. These two transformations could be combined into one pot to produce the desired product in moderate yield. Applications of this methodology to synthesize the fragments of variolaric acid were also studied.

Pyrrolo(oxo)isoquinolines as 5HT ligands

The present application describes compounds according to Formula I, pharmaceutical compositions, comprising at least one compound according to Formula I and optionally at least one additional therapeutic agent and methods of treating various diseases, conditions and disorders associated with modulation of serotonin receptors such as, for example: metabolic diseases, which includes but is not limited to obesity, diabetes, diabetic complications, atherosclerosis, impared glucose tolerance and dyslipidemia; central nervous system diseases which includes but is not limited to, anxiety, depression, obsessive compulsive disorder, panic disorder, psychosis, schizophrenia, sleep disorder, sexual disorder and social phobias; cephalic pain; migraine; and gastrointestinal disorders using compounds according to Formula I or pharmaceutically acceptable salt forms thereof, wherein A, B, D, E, m, n, R3, R7, R8, R9, R10, R11 and X are described herein.

MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS

The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1 -R11, t, X, Y, Z, and n are as defined herein.

PREPARATION OF ISOCOUMARIN DERIVATIVES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF

A method of preparing optically active isocoumarin-3-yl-acetic acid derivatives represented by Formula (I): wherein a specific isocoumarin-ketene derivative is subjected to an addition reaction with an optically active alcohol, and then the ester thus obtained is subjected to a hydrolysis reaction. An intermediate for synthesis used therein. A method of preparing isocoumarin-3-yl-acetic acid derivatives represented by Formula (III): wherein a specific isocoumarin derivative is subjected to an addition reaction with carbon monoxide and oxygen in the presence of a transition metal catalyst. An intermediate for synthesis used therein.

Total synthesis of phleichrome, calphostin A, and calphostin D. Unusual stereoselective and stereospecific reactions in the synthesis of perylenequinones

This report describes the total synthesis of phleichrome, calphostin A and calphostin D - three protein kinase C inhibitory perylenequinones. The present route affords the targets in enantiomerically pure form and represents the first successful approach

SYNTHESIS OF NATURALLY OCCURRING 2,5-DIALKYLCHROMONES. PART 1. SYNTHESIS OF ALOESONE AND ALOESOL

A number of 2-alkyl-7-alkoxy ( or hydroxy)-5-methyl-chromones, including naturally occurring aloesone and aloesol, were synthesized starting from ethyl orsellinate via β-keto-sulfoxides as intermediates.

Reactions of the Carbanion from an Orsellinate Derivative with Electrophiles

Esters of orsellinic acid dimethyl ether (11) are attacked by alkyl-lithium reagents to give ketones and in some cases smaller amounts of alkenes as a result of a second nucleophilic attack.However at -78 deg C attack on (11) by its own anion (10) is suff