10479-85-3

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 4-chlorocrotonate is used as a key intermediate for the synthesis of various pharmaceuticals, including antimalarial and anti-inflammatory medications. Its high reactivity allows for the efficient production of these drugs, contributing to the development of effective treatments for a variety of health conditions.
Used in Agrochemical Industry:
In the agrochemical sector, Ethyl 4-chlorocrotonate is utilized as an intermediate in the synthesis of various agrochemicals. Its role in the production of these compounds helps to ensure the availability of effective solutions for agricultural applications, such as pest control and crop protection.
Used in Flavors and Fragrances Industry:
Ethyl 4-chlorocrotonate is employed as a starting material in the manufacturing of flavors and fragrances. Its fruity odor makes it a valuable component in the creation of a wide range of scented products, enhancing the sensory experience of consumers.
Used in Organic Compounds Synthesis:
As a versatile intermediate, Ethyl 4-chlorocrotonate is used in the synthesis of various organic compounds. Its high reactivity and compatibility with different chemical processes make it an essential component in the production of a diverse array of organic substances, further expanding its applications across multiple industries.

Upstream product

• 1617-18-1 ethyl 3-butenoate 
• 86728-85-0 ethyl 4-chloro-3-hydroxybutanoate 
• 37746-78-4 4-bromo-trans-crotonic acid ethyl ester 
• 10080-68-9 (E)-ethyl 4-hydroxybut-2-enoate 
• 127758-95-6 ethyl 3-acetoxy-4-chlorobutanoate 

Downstream Products

• 59425-01-3 ethyl (E)-4-iodobut-2-enoate 
• 37746-78-4 4-bromo-trans-crotonic acid ethyl ester 
• 26340-58-9 4-chlorocrotonic acid 
• 10479-71-7 trans-2-methyl-1-(ethoxycarbonyl)cyclohexane 
• 24587-49-3 (2E)-4-hydroxybut-2-enoic acid 
• 64559-17-7 5-oxa-nona-2,7-dienedioic acid 
• 38090-53-8 trans-4-aminocrotonic acid 

Relevant academic research and scientific papers

Improved access to chiral tetranaphthoazepinium-based organocatalysts using aqueous ammonia as nitrogen source

The class of 3,30-diaryl substituted tetranaphthobisazepinium bromides has found wide application as highly efficient C2-symmetrical phase-transfer catalysts (PTCs, Maruoka type catalysts). Unfortunately, the synthesis requires a lar

Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases

Ene reductases from the Old Yellow Enzyme (OYE) family reduce the C=C double bond in α,β-unsaturated compounds bearing an electron-withdrawing group, for example, a carbonyl group. This asymmetric reduction has been exploited for biocatalysis. Going beyond its canonical function, we show that members of this enzyme family can also catalyze the formation of C?C bonds. α,β-Unsaturated aldehydes and ketones containing an additional electrophilic group undergo reductive cyclization. Mechanistically, the two-electron-reduced enzyme cofactor FMN delivers a hydride to generate an enolate intermediate, which reacts with the internal electrophile. Single-site replacement of a crucial Tyr residue with a non-protic Phe or Trp favored the cyclization over the natural reduction reaction. The new transformation enabled the enantioselective synthesis of chiral cyclopropanes in up to >99 % ee.