104795-56-4

Upstream product

• 5446-02-6 4-methoxymethylsalicylate 
• 216768-18-2 4-methoxy-2-(trifluoro-methanesulfonyloxy)-benzoic acid methyl ester 
• 104795-54-2 methyl 2-{[(dimethylamino)thiocarbonyl]oxy}-4-methoxybenzoate 
• 2237-36-7 4-methoxysalicylic acid 
• 67-56-1 methanol 
• 80568-44-1 2-mercapto-4-methoxybenzoic acid 
• 104795-55-3 methyl 2-{[(dimethylamino)carbonyl]thio}-4-methoxybenzoate 

Downstream Products

• 108318-75-8 methyl 2-(chlorosulfonyl)-4-methoxybenzoate 
• 944061-00-1 methyl 2-[(cyanomethyl)thio]-4-methoxybenzoate 
• 1260224-73-4 N-cyclopentyl-2-mercapto-4-methoxybenzamide 
• 1334317-70-2 C₂₆H₂₄ClNO₄S 
• 1334317-71-3 C₂₅H₂₂ClNO₄S 
• 1334317-72-4 C₂₅H₂₀ClNO₄S 
• 1334317-73-5 C₂₅H₂₀ClNO₄S 

Relevant academic research and scientific papers

HEPATITIS B CORE PROTEIN ALLOSTERIC MODULATORS

ABSTRACT The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

Synthesis and structure activity relationship studies of benzothieno[3,2-b]furan derivatives as a novel class of IKKβ inhibitors

As a novel class of IKKβ inhibitors, a series of tricyclic furan derivatives was designed and synthesized based on the structure of known thiophene IKKβ inhibitors. Among the various fused furan derivatives synthesized, a benzothieno[3,2-b]furan derivative 13a displayed potent inhibitory activity towards IKKβ in enzymatic and cellular assays. The potent inhibitory activity originates from an intramolecular non-bonded S...O interaction which was confirmed by the X-ray structure of JNK3 with 16k. The introduction of further substituents on the core structure led to the discovery of the 6-alkoxy derivatives, which possessed a comparable IKKβ inhibitory activity to 13a and an improved metabolic stability. Among these, appropriately lipophilic compounds 16a, h, i, and 13g (logD>2) were found to possess good oral bioavailability.

Endothelin receptor antagonists: Synthesis and structure-activity relationships of substituted benzothiazine-1,1-dioxides

The development of benzothiazine-1,1-dioxide derivatives as a new structural class of potent endothelin receptor antagonists is described. Structure-activity relationships (SAR) revealed that PD164800 (1) is a potent antagonist of the ET(A) receptor subtype. Copyright (C) 1998 Elsevier Science Ltd.

Herbicidal sulfonamides

This invention relates to a novel herbicidal sulfonamide, agriculturally suitable compositions and a method for using it as an herbicide.