10480-47-4

Upstream product

• 619-25-0 3-Nitrobenzyl alcohol 
• 104-94-9 4-methoxy-aniline 
• 99-61-6 3-nitro-benzaldehyde 
• 67-56-1 methanol 
• 62-53-3 aniline 

Downstream Products

• 38550-54-8 (4-Methoxy-phenylamino)-(3-nitro-phenyl)-acetonitrile 
• 1226791-24-7 C₁₈H₁₆N₄O₅ 
• 101971-72-6 N-(4'-methoxyphenyl)-3-nitrobenzamide 
• 1233714-05-0 1-(4-methoxyphenyl)-4-(3-nitrophenylmethylene)-6-[(Z)-2-(3-nitrophenyl)vinyl]-3H-1,3,5-triazin-2-one 
• 1412838-22-2 (5S,2'R,3'S)-5-isopropyl-3-phenyl-1-[2'-methyl-3'-(p-methoxyphenylamino)-3'-(m-nitrophenyl)propionyl]hydantoin 

Relevant academic research and scientific papers

Recyclable hydrotalcite catalysts for alcohol imination via acceptorless dehydrogenation

Here we report that hydrotalcite-like materials (HTs) are active heterogeneous catalysts for alcohol imination, which proceeds through acceptorless alcohol dehydrogenation. The catalytic activity of a series of Mg-Al hydrotalcites doped with Fe3+, Zn2+, Ni2+, Cr3+ and Cu2+ is dependent on their composition, and Fe : Mg : Al HT yields up to 92% imine under mild conditions. Impregnation of Fe : Mg : Al HT with Pd0 resulted in an enhancement of activity for acceptorless dehydrogenation, but a decrease in the isolated yield of imine in a loading-dependent manner. This is attributed to the Pd loading-dependent retention of imine and aldehyde on the catalysts. The substrate scope for alcohol imination and recyclability of the catalysts is discussed.

Development of hydroxamate-based histone deacetylase inhibitors of bis-substituted aromatic amides with antitumor activities

Previously, we designed and synthesized a series of bis-substituted aromatic amide-based histone deacetylase (HDAC) inhibitors. In this study, we report the replacement of a bromine atom by different amides on the phenyl ring of the CAP region. Representa

Spectroscopic and semi-empirical MO study of substituent effects on the intramolecular proton transfer in anils of 2-hydroxybenzaldehydes

Substituent effects in singly and doubly substituted anils of 2- hydroxybenzaldehyde showing strong intramolecular hydrogen bonding are studied on the basis of solution 13C NMR spectroscopic data and semiempirical MO (AM1) calculations of the r

NADH Model Studies on the Glutamate Dehydrogenase Mechanism

N-Arylidenecyclohexylamines and anilines in glacial acetic acid are reduced by the Hantzch ester (3) to give the N-benzylaniline derivatives (6) in good yields by a route analogous to a suggested mechanism for glutamate dehydrogenase.

Enantioselective Direct anti-Selective Mannich-type Reactions Catalyzed by 3-Pyrrolidinecarboxylic Acid in the Presence of Potassium Carbonate: Addition of Potassium Carbonate Improves Enantioselectivities

Mannich-type reactions of cyclohexanone and related six-membered-ring ketones with N-p-methoxyphenyl-protected imines of arylaldehydes catalyzed by 3-pyrrolidinecarboxylic acid in the presence of K2CO3 that afford anti-isomers of the Mannich products with

A sustainable catalytic enantioselective synthesis of norstatine derivatives

Norstatine derivatives are of important value in pharmaceutical science. However, their catalytic asymmetric synthesis is rare. We developed a sustainable method via chiral phosphoric acid (CPA)-[Rh(OAc)2]2 co-catalyzed multi-component reactions (MCR) of diazoacetates with alcohol/water and imines. This method allows us to synthesize a library of 45 norstatines with excellent enanotioselectivites and broad substrate scope which includes anti-α-aryl-norstatines 11-1, anti-α-alkyl-norstatines 11-2, syn-α-hydro-norstatines 11-3 and syn-α-aryl-norstatines 11-4. The sustainability of this method lies in the reliable scalability, improved safety, and reusable [Rh(OAc)2]2 catalyst. The synthetic value of norstatine derivatives was demonstrated by preparing oxazolinone 14, ezetimibe analogue 15, and Taxol C-13 chain 16. Mechanistic study reveals that the synergetic catalysis of CPA and [Rh(OAc)2]2 is essential to maintain chemo- and enantioselectivity. Control experiments support the mechanism where the reactions proceed through the trapping of hyper-reactive oxonium ylides with imines. Shortly, we report herein the sustainable catalytic enantioselective synthesis of both syn- and anti-norstatine derivatives. We believe that this method might shed light on the sustainable synthesis of norstatine derivative-based drug candidates.

Ru Nanoparticles-Loaded Covalent Organic Framework for Solvent-Free One-Pot Tandem Reactions in Air

Condensation of benzene-1,3,5-tricarbohydrazide with benzene-1,4-dicarboxaldehyde generated a new covalent organic framework, COF-ASB (1), in which the organic units are held together via hydrazone linkage to form porous frameworks. COF-ASB (1) is highly crystalline and displays good chemical and thermal stability and is permanently porous. In addition, 1 can be an ideal support to load Ru nanoparticles (Ru NPs) to generate Ru@COF-ASB (2). The obtained composite material is able to highly promote one-pot tandem synthesis of imine products from benzyl alcohols and corresponding amines under solvent-free conditions in air.

FeCl3-Mediated One-Pot Cyclization–Aromatization of Anilines, Benzaldehydes, and Phenylacetylenes under Ball Milling: A New Alternative for the Synthesis of 2,4-Diphenylquinolines

A straightforward and efficient method has been developed for the solvent-free synthesis of 2,4-diphenylquinolines via a one-pot reaction of anilines, benzaldehydes, and phenylacetylenes promoted by FeCl3 under solvent-free mechanochemical ball

One-pot sequential multicomponent reaction between: In situ generated aldimines and succinaldehyde: Facile synthesis of substituted pyrrole-3-carbaldehydes and applications towards medicinally important fused heterocycles

An efficient sequential multi-component method for the synthesis of N-Arylpyrrole-3-carbaldehydes has been developed. This reaction involved a proline-catalyzed direct Mannich reaction-cyclization sequence between succinaldehyde and in situ generated Ar/H

Paclitaxel Biosynthesis: Adenylation and Thiolation Domains of an NRPS TycA PheAT Module Produce Various Arylisoserine CoA Thioesters

Structure-activity relationship studies show that the phenylisoserinyl moiety of paclitaxel (Taxol) is largely necessary for the effective anticancer activity. Several paclitaxel analogues with a variant isoserinyl side chain have improved pharmaceutical