1048007-30-2Relevant academic research and scientific papers
Oxidative Dehydrosulfurative Carbon-Oxygen Cross-Coupling of 3,4-Dihydropyrimidine-2-thiones with Aryl Alcohols
Phan, Trong Nguyen Huu,Lee, Jihong,Shin, Hyunik,Sohn, Jeong-Hun
, p. 5423 - 5430 (2021/05/05)
A Pd-catalyzed/Cu-mediated oxidative dehydrosulfurative carbon-oxygen cross-coupling reaction of 3,4-dihydropyrimidin-1H-2-thiones (DHPMs) with aryl alcohols is described. Due to the ready availability of diverse DHPMs and aryl alcohols, the reaction method offers facile access to biologically and pharmacologically valuable 2-aryloxypyrimidine derivatives with rapid diversification.
Aerobic copper-promoted oxidative dehydrosulfurative carbon-oxygen cross-coupling of 3,4-dihydropyrimidine-1: H -2-thiones with alcohols
Kwon, Yujeong,Lee, Dong-Chan,Lee, Jihong,Sohn, Jeong-Hun
, p. 36821 - 36825 (2021/12/02)
An aerobic Cu-promoted oxidative dehydrosulfurative carbon-oxygen cross-coupling of 3,4-dihydropyrimidin-1H-2-thiones (DHPMs) with both aliphatic and aromatic alcohols is described. Together with the ready availability of DHPMs and both alcohols, the meth
C-O and C-S coupling reaction of 1,2-di(pyrimidin-2-yl) disulfides with phenols/thiophenols promoted by copper(I) chloride
Zhang, Ping,Guo, Yan,Quan, Zheng-Jun
, (2017/10/27)
An efficient protocol for C-O and C-S bonds formation by the cross-coupling reaction of 1,2-di(pyrimidin-2-yl) disulfides with phenols/thiophenols promoted by copper(I) chloride was established. It was discovered that variously substituted di(hetero)aryl disulfides and phenols were well tolerated. This strategy is the conversion of disulfides into hetero-aryl ethers and thioethers by a copper-promoted chemoselective C-S bond cleavage of disulfides.
Cross-coupling reactions of pyrimidin-2-yl sulfonates with phenols and anilines: An efficient approach to C2-functionalized pyrimidines
Quan, Zhengjun,Jing, Fuqiang,Zhang, Zhang,Da, Yuxia,Wang, Xicun
supporting information, p. 1495 - 1502 (2014/01/06)
Pyrimidin-2-yl sulfonates, as an efficient reaction partner, which can be easily prepared from cheap commercial materials, were coupled with phenols and anilines to give a wide array of C2-aryloxy- and arylaminopyrimidines in good to excellent yields under mild reaction conditions. Copyright
Pd-catalyzed direct arylation of tautomerizable heterocycles with aryl boronic acids via C-OH bond activation using phosphonium salts
Kang, Fu-An,Sui, Zhihua,Murray, William V.
supporting information; experimental part, p. 11300 - 11302 (2009/02/05)
The first direct arylation via C-OH bond activation of tautomerizable heterocycles has been achieved using phosphonium salts, on the basis of a combination of the phosphonium coupling and Suzuki-Miyaura cross-coupling conditions. Optimal reaction condition is obtained through screening of phosphonium salts, Pd catalysts, and bases. The direct arylation via C-OH bond activation tolerates a variety of tautomerizable heterocycles and aryl boronic acids. The mechanism of the Pd-catalyzed phosphonium coupling is proposed to proceed via a domino seven-step process including the unprecedented heterocycle-Pd(II)-phosphonium species. Application of the Pd-catalyzed direct arylation via C-OH bond activation using PyBroP leads to the most efficient synthesis of the biologically important 6-arylpurine ribonucleoside in a single step from unactivated and unprotected inosine. Copyright
