104819-25-2

Upstream product

• 1071-46-1 hydrogen ethyl malonate 
• 104819-28-5 2-(1-Benzyl-1H-indol-3-yl)-1-imidazol-1-yl-ethanone 
• 104819-24-1 1-benzylindole-3-acetic chloride 
• 4307-97-5 N-benzylindole-3-acetic acid 
• 100-44-7 benzyl chloride 
• 87-51-4 indole-3-acetic acid 
• 4111-54-0 lithium diisopropyl amide 

Downstream Products

• 104845-30-9 3-(1-Benzyl-1H-indol-3-ylmethyl)-9-ethyl-8-methyl-2-oxa-8-aza-bicyclo[3.3.1]non-3-ene-4-carboxylic acid ethyl ester 
• 104819-33-2 4-(1-Benzyl-1H-indol-3-yl)-2-(2-cyano-3-ethyl-1-methyl-piperidin-4-yl)-3-oxo-butyric acid ethyl ester 

Relevant academic research and scientific papers

REACTIONS OF β-KETO ESTERS WITH 2-CYANO-1,2,5,6-TETRAHYDROPYRIDINES

Reaction of the sodium salts of β-keto esters 13a and 13b with the 2-cyano-tetrahydropyridines 11 and 12 afforded the 4-substituted piperidine derivatives 21-23.The structures were assigned on the basic of their (1)H-and (13)C-NMR spectra and by comparison with the model compounds 24-26.The stereochemistry and the mechanism of the reactions are discussed.