104857-33-2Relevant academic research and scientific papers
Reaction of 5-(3,4-Dimethoxyphenyl)pyrazine-2,3-dicarbonitrile with Alkyl Radicals
Tada, Masaru,Momose, Hiroshi
, p. 1357 - 1361 (2007/10/02)
The reaction of 5-(3,4-dimethoxyphenyl)pyrazine-2,3-dicarbonitrile (Ib) with alkyl radicals gives addition products at the C(6)-position of the pyrazine ring as the intermediates which collapse into substitution products, 6-alkyl-5-(3,4-dimethoxyphenyl)pyrazine-2,3-dicarbonitrile (II), under oxidative conditions.Under non-oxidative conditions the intermediate is converted into dihydropyrazine derivatives, 6-alkyl-(3,4-dimethoxyphenyl)-5,6-dihydropyrazine-2,3-dicarbonitrile (III), and 3,6-disubstituted pyrazine derivatives, 3,6-dialkyl-5-(3,4-dimethoxyphenyl)pyrazine-2-carbonitrile (IV) and 3-acyl-6-alkyl-5-(3,4-dimethoxyphenyl)pyrazine-2-carbonitrile (V).
