104864-75-7Relevant academic research and scientific papers
Synthesis of α-Thiooximes by Addition of Thiols to N, N -Bis(oxy)-enamines: A Comparative Study of S-, N-, and O-Nucleoa-philes in Michael Reaction with Nitrosoalkene Species
Naumovich, Yana A.,Kokuev, Aleksandr O.,Sukhorukov, Alexey Yu.,Ioffe, Sema L.
, p. 1334 - 1339 (2018/04/19)
Nucleophilic addition of thiols to N, N -bis(oxy)enamines (nitrosoalkene acetals) produce valuable α-thiooximes in a highly efficient manner. The reaction was found to be solvent-dependent, likely because of distinct mechanisms operating in nonpolar and basic solvents (involving either Bronsted acid or Lewis base catalysis). By performing a series of competition experiments, the relative reactivity of S-, N-, and O-nucleophiles in reaction with N, N -bis(oxy)enamines was determined for the first time. Interestingly, the relative nucleophilicity was found to be highly dependent on the solvent, which allows regioselective control of these reactions by using an appropriate medium.
A sulfur-containing amino acid amide carbamate derivative and application thereof
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, (2017/08/09)
The invention belongs to the field of plant fungicides, and relates to sulfur-containing amino acid amide carbamate derivatives of which the general formulas I are shown in the description and pharmaceutically acceptable salts of the sulfur-containing amino acid amide carbamate derivatives. In the general formulas I, substituent groups R1, R2 and n are defined in the description. The invention further relates to preparation methods of compounds related to the general formulas I, special intermediates developed for the preparation of the compounds, and application of the compounds to prevention and control of plant diseases.
