1200-13-1

Usage

Uses

Used in Chemical Synthesis:
(4-METHYLPHENYLTHIO)ACETONE is used as an intermediate in the synthesis of other chemicals for various applications, leveraging its organosulfur properties to facilitate chemical reactions and produce desired products.
Used in Pharmaceutical Industry:
(4-METHYLPHENYLTHIO)ACETONE is used as a building block in the development of pharmaceutical compounds, potentially contributing to the creation of new drugs or improving the synthesis processes of existing medications.
Used in Industrial Applications:
(4-METHYLPHENYLTHIO)ACETONE may find use in various industrial applications, such as the production of specialty chemicals, agrochemicals, or materials science, where its unique properties can be harnessed to enhance product performance or manufacturing processes.
It is important to handle (4-METHYLPHENYLTHIO)ACETONE with care, adhering to proper safety measures including the use of protective clothing, gloves, and eye/face protection. Further research is needed to understand its toxicity and ecological effects fully.

InChI:InChI=1/C10H12OS/c1-8-3-5-10(6-4-8)12-7-9(2)11/h3-6H,7H2,1-2H3

Upstream product

• 10486-08-5 sodium p-thiocresolate 
• 78-95-5 chloroacetone 
• 106-45-6 para-thiocresol 
• 598-31-2 1-bromoacetone 
• 56742-98-4 1-<(4-methylphenyl)sulphinyl>propan-2-one 
• 880095-10-3 1-chloro-2-(4-tolylthio)propan-2-yl acetate 
• 933-00-6 p-methylbenzenesulfenyl chloride 
• 1219622-14-6 S-adenosyl-S-(propan-2-one)-L-methionine 
• 367-57-7 1,1,1-Trifluoro-2,4-pentanedione 
• 103-19-5 di(p-tolyl) disulfide 
• 93-91-4 1-phenylbutan-1,3-dione 
• 123-54-6 acetylacetone 
• 67-64-1 acetone 
• 2564-83-2 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical 

Downstream Products

• 51351-89-4 nitromethyl p-tolyl sulfone 
• 1964-45-0 3,5-dimethylbenzothiophene 
• 856981-15-2 1-chloro-1-p-tolylsulfanyl-acetone 
• 104864-75-7 1-methyl-2-p-tolylmercaptoethylamine 
• 56742-98-4 1-<(4-methylphenyl)sulphinyl>propan-2-one 
• 21571-70-0 <2-Chlormethyl-4-methyl-phenylmercapto>-aceton 
• 155397-53-8 1-(2-Cyclopropylidene-propylsulfanyl)-4-methyl-benzene 
• 5366-49-4 4-toluenesulfonylacetone 
• 66536-78-5 (+)-(R)-1-(p-tolylsulfinyl)-2-propanone 
• 127583-42-0 1-((S)-Toluene-4-sulfinyl)-propan-2-one 
• 5877-09-8 2-(4-methylphenylthio)-1-methylethanol 
• 56146-64-6 2-(p-toluenesulfinyl)-cyclohexanone 
• 104871-67-2 (R)-2-(p-tolylsulfinyl)-1-cyclohexanone 
• 127583-43-1 6-Bromo-1-(toluene-4-sulfinyl)-hexan-2-one 

Relevant academic research and scientific papers

Air-stable binuclear Titanium(IV) salophen perfluorobutanesulfonate with zinc power catalytic system and its application to C–S and C–Se bond formation

An air-stable μ-oxo-bridged binuclear Lewis acid of titanium(IV) salophen perfluorobutanesulfonate [{Ti(salophen)H2O}2O][OSO2C4F9]2 (1) was successfully synthesized by the reaction of TiIV(salophen)Cl2 with AgOSO2C4F9 and characterized by techniques such as IR, NMR and HRMS. This complex was stable open to air over a year, and exhibited good thermal stability and high solubility in polar organic solvents. The complex also had relatively strong acidity with a strength of 0.8 Ho ≤ 3.3, and showed high catalytic efficiency towards various C–S and C–Se bond formations in the presence of zinc power. This catalytic system affords a mild and efficient approach to synthesis of thio- and selenoesters, α-arylthio- and seleno-carbonyl compounds, and thio- and selenoethers.

Synthesis of α-arylthioacetones using TEMPO as the: C 3 synthon via a reaction cascade of sequential oxidation, skeletal rearrangement and C-S bond formation

Here, we present an unprecedented pathway to α-sulfenylated carbonyl compounds from commercially available thiols and universally employed TEMPO and its analogues, which act as C3 synthons through skeletal rearrangement under simple and metal-f

Synthesis of a new series of Ni(II), Cu(II), Co(II) and Pd(II) complexes with an ONS donor Schiff base: Crystal structure, DFT study and catalytic investigation of palladium and nickel complexes towards deacylative sulfenylation of active methylenes and regioselective 3-sulfenylation of indoles: Via thiouronium salt formation

A series of Ni(ii), Cu(ii), Co(ii), and Pd(ii) complexes have been synthesized with a chelating Schiff base ligand coordinated to a metal center with ONS donor atoms. The ligand and complexes are characterized by elemental analysis and spectroscopic techniques like FT-IR, 1H-NMR, and UV-Visible spectroscopy. The single crystal structure of the Pd(ii) complex is obtained by X-ray diffraction analysis and exhibits slightly distorted square planar geometry. The structure is optimized by DFT, TD-DFT calculation to elaborate the electronic structure and NBO for the charge distribution analysis of the Pd(ii) complex. The synthesized Pd(ii) and Ni(ii) complexes as catalysts have been investigated in the C-S cross-coupling of indoles and active methylenes. The metal propelled regioselective transformation afforded 3-sulfenylated indoles while β-diketones favored deacylated monosulfenyl ketones in an excellent yield via thiouronium salt formation. The Pd(ii) complex displays slightly better reactivity whereas the Ni(ii) complex is cost-efficient. The method is fast, easy to handle and cost effective in terms of high reactivity of catalysts, use of non-toxic solvents, and cheaper aryl halides and thiourea replace conventional sulfur sources, providing a practical access to organic transformations.

An Unexpected Domino Reaction of β-Keto Sulfones with Acetylene Ketones Promoted by Base: Facile Synthesis of 3(2H)-Furanones and Sulfonylbenzenes

An unexpected domino reaction of β-keto sulfones with acetylene ketones has been developed. The domino reaction of β-keto sulfones with diynones proceeded smoothly in the presence of 30 mol% K2CO3 without other additives, and afforded the novel 3(2H)-furanone derivatives. On replacing the diynones with terminal alkyne ketones, the reaction regioselectivity was changed and sulfonylbenzenes were obtained via benzannulation in good yields. (Figure presented.).

Cs2CO3-promoted carbon–sulfur bond construction via cross dehydrogenative coupling of thiophenols with acetonitrile

A novel protocol for the construction of carbon–sulfur bonds has been achieved via halogen-free Cs2CO3-promoted cross dehydrogenative coupling (CDC) of thiophenols with acetonitrile. This transformation provides a straightforward route to the synthesis of sulfenylated acetonitriles in up to 80% yield.

A sulfur-containing amino acid amide carbamate derivative and application thereof

The invention belongs to the field of plant fungicides, and relates to sulfur-containing amino acid amide carbamate derivatives of which the general formulas I are shown in the description and pharmaceutically acceptable salts of the sulfur-containing amino acid amide carbamate derivatives. In the general formulas I, substituent groups R1, R2 and n are defined in the description. The invention further relates to preparation methods of compounds related to the general formulas I, special intermediates developed for the preparation of the compounds, and application of the compounds to prevention and control of plant diseases.

Fe-Mediated S-S Bond Cleavage and Its Application in the Synthesis of α-Arylthio Carbonyl Compounds

In the presence of iron dust, diaryl disulfides react with α-bromo carbonyl compounds to obtain α-arylthio carbonyl compounds in good yield at 90 °C under an N2 atmosphere, using commercial dimethylformamide (DMF) as solvent. The possible reaction mechanism is that the disulfide is reduced by iron dust to give ArSFeSAr and then reacted with α-bromo carbonyl compounds to give product α-arylthio carbonyl compounds and FeBr2.

α-Arylchalcogenation of acetone with diaryl dichalcogenide via metal-free oxidative C(sp3)-H bond functionalization

Direct α-arylchalcogenation of acetone with diaryl dichalcogenides has been achieved by using a mixture of TBHP and DTBP oxidants at 120 °C without transition-metal catalyst via oxidative C(sp3)-H bond functionalization. The method exhibits good functional group tolerance and products were isolated in moderate to high yields.

Hydroxysulfenylation of electron-deficient alkenes through an aerobic copper catalysis

A copper-catalyzed hydroxysulfenylation of α,β-unsaturated esters/amides is reported. The method presents a selective and efficient synthesis of β-hydroxysulfides bearing electron-withdrawing groups. The synthetic utility of this method is demonstrated by the concise synthesis of the anticancer drug bicalutamide.

Copper-Catalyzed Synthesis of α-Thioaryl Carbonyl Compounds Through S-S and C-C Bond Cleavage

A method to access α-thioaryl ketones and α-thioaryl esters employing copper acetate (hydrate) as catalyst and readily accessible diaryl disulfides and β-diketones (or β-keto esters) has been developed. Both alkyl- and aryl-substituted carbonyl compounds can be prepared. Copyright