1048667-28-2Relevant academic research and scientific papers
Synthesis and biological evaluation of modified 2-deoxystreptamine dimers
Coste, Gerald,Horlacher, Tim,Molina, Lidia,Moreno-Vargas, Antonio J.,Carmona, Ana T.,Robina, Inmaculada,Seeberger, Peter H.,Gerber-Lemaire, Sandrine
scheme or table, p. 1759 - 1770 (2011/07/30)
Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for analogues with better pharmacological profiles. The synthesis of 2-deoxystreptamine (2-DOS) dimers linked by polyamines and analogues based on furylcarbopeptoid skeletons is described. Potent and selective ligands for bacterial 16S rRNA were identified using microarray techniques by determining the affinity of these derivatives toward bacterial and human ribosomal RNAs. Georg Thieme Verlag Stuttgart - New York.
Synthesis and biological evaluation of S-neofucopeptides as E- and P-selectin inhibitors
Moreno-Vargas, Antonio J.,Molina, Lidia,Carmona, Ana T.,Ferrali, Alessandro,Lambelet, Martine,Spertini, Olivier,Robina, Inmaculada
experimental part, p. 2973 - 2982 (2009/04/11)
The synthesis of α/β-L-fucosylated cysteamine, 3-thiopropionic acid, and 3-thioacetic acid derivatives as building blocks for the preparation of S-neofucopeptides is shown. These compounds were used in the synthesis of new thiofucosides derivatives (8α, 9α, 9β, 10α, 22α, 22β, 24α, 26α) that show affinity towards E- and P-selectins. They constitute a new series of hydrolytically stable and low-molecular-weight mimetics of the natural SLex tetrasaccharide. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
