1048677-12-8

Basic information

• Product Name: benzyl 4-iodo-3,5-dimethylbenzoate
• Synonyms: benzyl 4-iodo-3,5-dimethylbenzoate
• CAS NO: 1048677-12-8
• Molecular Weight: 366.198
• Mol File: 1048677-12-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: benzyl 4-iodo-3,5-dimethylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 4-iodo-3,5-dimethylbenzoate(1048677-12-8)
• EPA Substance Registry System: benzyl 4-iodo-3,5-dimethylbenzoate(1048677-12-8)

Safety Data

• Hazardous Substances Data: 1048677-12-8(Hazardous Substances Data)

Upstream product

• 1048677-11-7 4-iodo-3,5-dimethylbenzoic acid 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 

Downstream Products

• 1048677-13-9 benzyl (S)-4-(3-methoxy-2-methyl-3-oxopropyl)-3,5-dimethylbenzoate 

Relevant articles and documents

Novel method for preparing iludoline intermediate

The invention discloses a preparation method of a pharmaceutical intermediate, 4-(aminocarbonyl)-N-[(1,1-dimethylethoxy)carbonyl]-2,6-dimethyl-L-phenylalanine methyl ester, for treating irritable bowel syndrome (IBS-D). The preparation method comprises the following steps: with 4-iodine-3,5-dimethyl benzoic acid as a raw material, protecting carboxyl through a group, carrying out Negishi couplingreaction under the catalysis of Pd2(dba)3, removing the carboxyl protecting group, and forming active ester to react with ammonia water, thereby obtaining the product. The invention provides a novel synthetic route for a drug intermediate for treating irritable bowel syndrome (IBS-D); the reaction conditions are easy to control, the post-treatment operation is simple, and industrial production canbe smoothly realized.