1048703-15-6

Basic information

• Product Name: tert-butyl (R)-(4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
• Synonyms: tert-butyl (R)-(4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate
• CAS NO: 1048703-15-6
• Molecular Weight: 317.308
• Mol File: 1048703-15-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: tert-butyl (R)-(4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (R)-(4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate(1048703-15-6)
• EPA Substance Registry System: tert-butyl (R)-(4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate(1048703-15-6)

Safety Data

• Hazardous Substances Data: 1048703-15-6(Hazardous Substances Data)

Upstream product

• 157911-56-3 2,4,5-trifluorobenzyl bromide 
• 680993-47-9 1-allyl-2,4,5-trifluorobenzene 
• 1048703-14-5 (R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate 

Downstream Products

• 1048703-16-7 [(R)-3-(3-phenyl-piperidin-1-yl)-1-(2,4,5-trifluoro-benzyl)-propyl]-carbamic acid tert-butyl ester 
• 486460-00-8 (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid 

Relevant articles and documents

Synthesis of (?)-(R)-Sitagliptin by RhI-Catalyzed Asymmetric Hydroamination

We report of a concise synthesis of (R)-sitagliptin monophosphate – a drug predominantly applied in the treatment of type 2 diabetes. Utilizing our recently developed RhI-catalyzed hydroamination of allenes for the stereoselective construction of the inherent chiral amino function, a new approach to (R)-sitagliptin monophosphate on a 3.5 mmol scale was established.

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