1048703-18-9

Usage

Uses

(R)-3-(4-Fluorophenyl)pyrrolidine is a quinoline that is used as CRTH2 receptor modulators.

Upstream product

• 144620-11-1 3-(4-fluorophenyl)pyrrolidine 
• 1263285-96-6 tert-butyl 3-(4-fluorophenyl)pyrrolidine-1-carboxylate 
• 1201986-72-2 (R)-tert-butyl 3-(4-fluorophenyl)pyrrolidine-1-carboxylate 
• 1493-23-8 (4-fluorophenyl)lithium 
• 220474-60-2 1-benzyl-3-(4'-fluorophenyl)pyrrolidine 

Downstream Products

• 1201986-55-1 ((R)-3-(4-fluorophenyl)pyrrolidin-1-yl)((2S,4R)-4-(fluorophenyl)pyrrolidin-2-yl)methanone hydrochloride 
• 1201987-30-5 (2S,4R)-tert-butyl 4-(4-fluorophenyl)-2-((R)-3-(4-fluorophenyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate 
• 1201986-72-2 (R)-tert-butyl 3-(4-fluorophenyl)pyrrolidine-1-carboxylate 

Relevant academic research and scientific papers

HETEROCYCLIC DERIVATIVES AS IAP BINDING COMPOUNDS

The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts, solvates thereof, that bind to Inhibitor of Apoptosis Proteins (IAPs). The compounds of the invention may be used as diagnostic and therapeutic agents in the

ORGANIC COMPOUNDS

A compound of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof, and their preparation and use as pharmaceuticals (I) wherein R1 R2 R3, R4 and W are as defined herein.

ADENOSINE DERIVATIVES HAVING A2A RECEPTOR ACTIVITY

Compounds of (I), or stereoisomers or pharmaceutically acceptable salts thereof, where W, R1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating conditions mediated by activation of the adenosine A2A receptor, especially inflammatory or obstructive airways diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

N-Substituted-3-arylpyrrolidines: Potent and Selective Ligands at Serotonin 1A Receptor

3-Arylpyrrolidines are synthesized through the coupling of N-benzyl-3-(methanesulfonyloxy)pyrrolidine with diarylcuprates. Pharmacological evaluation of a series of N-substituted-3-arylpyrrolidines toward several neurotransmitter receptors indicated that some of them are good ligands for serotonin 1A receptor. Particularly, N-pyrrolidines were found to be potent and selective ligands. A preliminary biological evaluation for several selected compounds indicated that they are potentially effective antianxiety and antidepressant agents.