1048703-29-2Relevant academic research and scientific papers
Enantioselective α-arylation of O-carbamates via sparteine-mediated lithiation and Negishi cross-coupling
Royal, Titouan,Baumgartner, Yann,Baudoin, Olivier
supporting information, p. 166 - 169 (2017/11/27)
A general and highly enantioselective arylation of carbamates derived from primary alcohols was developed by combining Hoppe's sparteine-mediated asymmetric lithiation with Negishi cross-coupling. Coupled with Aggarwal's lithiation-borylation sequence, the current method provides a short and divergent access to a variety of enantioenriched secondary and tertiary benzylic alcohols.
Determination of the effect of cation-π interactions on the stability of α-oxy-organolithium compounds
Monje, Pablo,Paleo, M. Rita,Garcia-Rio, Luis,Sardina, F. Javier
supporting information; experimental part, p. 7394 - 7397 (2009/05/07)
(Chemical Equation Presented) Sn-Li exchange equilibria have allowed the quantification of the stabilizing effect of cation-π interactions in organolithium chemistry. Stabilization energy data on the effect of Li-π complexation of an aromatic ring or a C=C double bond in organolithium compounds are presented. The amount of stabilization gained by complexation of the Li atom with a π system in α-oxy-organolithium compounds is quite comparable to the one observed in systems containing Li-N or Li-O interactions.
